CAS No. 14976-57-9

Batch: Purity:99.98
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Clemastine (HS-592) Fumarate Chemical Structure
Chemical Structure
Check the Clemastine (HS-592) Fumarate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (E)-but-2-enedioic acid;(2R)-2-[2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine
CAS Number 14976-57-9
Molecular Formula

C21H26ClNO.C4H4O4
Molecular Weight (MW) 459.96
SMILES CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCC3CCCN3C.C(=CC(=O)O)C(=O)O
InChIKey PMGQWSIVQFOFOQ-YKVZVUFRSA-N

Biological Activity

Clemastine Fumarate is a selective histamine H1 receptor antagonist that effectively blocks endogenous histamine signaling. By inhibiting histamine H1 receptors, the compound modulates downstream signaling cascades, including the mTOR pathway, which subsequently stimulates autophagy. Furthermore, clemastine acts on target pathways to promote oligodendrocyte precursor cell differentiation, driving cellular maturation and enhancing myelination in central nervous system models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 50 mg/mL (108.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Mei F, et al. Nat Med. 2014;20(8):954-960.

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Note: Technical data last updated: Sep 1, 2026.