CAS No. 113852-37-2

Batch: Purity:99.89
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Cidofovir Chemical Structure
Chemical Structure
Check the Cidofovir product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethylphosphonic acid
CAS Number 113852-37-2
Molecular Formula

C8H14N3O6P
Molecular Weight (MW) 279.19
SMILES C1=CN(C(=O)N=C1N)CC(CO)OCP(=O)(O)O
InChIKey VWFCHDSQECPREK-LURJTMIESA-N

Biological Activity

Cidofovir is an acyclic nucleoside phosphonate antiviral agent that functions as a potent inhibitor of viral DNA polymerase. Upon intracellular phosphorylation to its active diphosphate metabolite, it selectively inhibits viral DNA synthesis by competing with deoxycytidine triphosphate and incorporating into nascent viral DNA strands. This incorporation leads to premature DNA chain termination, thereby suppressing viral replication in infected cells.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 5 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.