CAS No. 69-09-0
| IUPAC Name | 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine;hydrochloride | |
|---|---|---|
| CAS Number | 69-09-0 | |
| Molecular Formula |
C17H19ClN2S.HCl |
|
| Molecular Weight (MW) | 355.33 | |
| SMILES | CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl.Cl | |
| InChIKey | FBSMERQALIEGJT-UHFFFAOYSA-N |
Chlorpromazine HCl is a dopamine receptor antagonist and potassium channel inhibitor. It selectively targets dopamine receptors and blocks inward-rectifying and time-independent outward potassium currents in cellular membranes. By inhibiting dopamine receptor signaling, Chlorpromazine HCl modulates central dopamine turnover and downstream prolactin release. Furthermore, its inhibition of potassium channel conductances regulates membrane potential, cellular excitability, and transmembrane ion transport. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
71 mg/mL
(199.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 71 mg/mL |
| Ethanol | 71 mg/mL |
| DMSO |
71 mg/mL
(199.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 71 mg/mL |
| Ethanol | 71 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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