CAS No. 3895-92-9

Batch: Purity:99.53
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Chelerythrine Chloride (NSC 646662) Chemical Structure
Chemical Structure
Check the Chelerythrine Chloride (NSC 646662) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium chloride
CAS Number 3895-92-9
Molecular Formula

C21H18NO4.HCl
Molecular Weight (MW) 384.83
SMILES C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.[Cl-]
InChIKey WEEFNMFMNMASJY-UHFFFAOYSA-M

Ordering Information

Biological Activity

Chelerythrine chloride is a natural plant-derived benzophenanthridine alkaloid that acts as a potent, selective, and cell-permeable inhibitor of protein kinase C (PKC) with an IC50 of 0.66 μM. By targeting PKC-mediated signaling pathways, chelerythrine effectively modulates key downstream cellular functions, demonstrating broad-spectrum biological activity that encompasses anti-inflammatory, antiplatelet, antibacterial, and antitumor effects in cellular models. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 3 mg/mL (7.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.