CAS No. 693228-63-6

Batch: Purity:99.52
Check CoA
CYC116 Chemical Structure
Chemical Structure
Check the CYC116 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-methyl-5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine
CAS Number 693228-63-6
Molecular Formula

C18H20N6OS
Molecular Weight (MW) 368.46
SMILES CC1=C(SC(=N1)N)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4
InChIKey GPSZYOIFQZPWEJ-UHFFFAOYSA-N

Ordering Information

Biological Activity

CYC116 is an orally bioavailable inhibitor targeting Aurora A, Aurora B, and VEGFR2. Disruption of Aurora kinase activity impairs cell cycle progression, interfering with spindle assembly, chromosome alignment, and cytokinesis during mitosis, which ultimately induces apoptotic cell death. Concurrently, suppression of VEGFR2 signaling contributes to the inhibition of tumor angiogenesis and reduces cell proliferation across various neoplastic models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 24 mg/mL (65.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.