CAS No. 51333-22-3

Batch: Purity:99.97
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Budesonide Chemical Structure
Chemical Structure
Check the Budesonide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-propyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
CAS Number 51333-22-3
Molecular Formula

C25H34O6
Molecular Weight (MW) 430.53
SMILES CCCC1OC2CC3C4CCC5=CC(=O)C=CC5(C4C(CC3(C2(O1)C(=O)CO)C)O)C
InChIKey VOVIALXJUBGFJZ-KWVAZRHASA-N

Biological Activity

Budesonide is a synthetic glucocorticoid steroid that functions as a potent glucocorticoid receptor agonist. Upon binding to the glucocorticoid receptor, it promotes receptor nuclear translocation and inhibits pro-inflammatory transcription factor pathways, including NF-kB. This action suppresses the expression of inflammatory cytokines and mediators, resulting in significant anti-inflammatory responses in airway cellular and tissue models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 86 mg/mL (199.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 10 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.