SMILES:
CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC
Chemical Structure
Check the
SKI-606 (Bosutinib)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | |
|---|---|---|
| CAS Number | 380843-75-4 | |
| Molecular Formula |
C26H29Cl2N5O3 |
|
| Molecular Weight (MW) | 530.45 | |
| SMILES | CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC | |
| InChIKey | UBPYILGKFZZVDX-UHFFFAOYSA-N |
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(188.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(188.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(188.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(188.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 9 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(188.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 16 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- SKI-606 (Bosutinib) Mechanism of Action: BCR-Abl Inhibition in Leukemia Cell Research
- SKI-606 (Bosutinib) Clinical Trials
- SKI-606 (Bosutinib) Working Concentration | Cell Culture | Treatment
- SKI-606 (Bosutinib) Solubility in DMSO
- SKI-606 (Bosutinib) Stock Solution
- SKI-606 (Bosutinib) Storage
- SKI-606 (Bosutinib) Stability
- SKI-606 (Bosutinib) Combination Database
- SKI-606 (Bosutinib) Molecular Weight
- SKI-606 (Bosutinib) CAS Number
- SKI-606 (Bosutinib) Chemical Structure (2D and 3D)
- SKI-606 (Bosutinib) IC50 for Cell-based and Cell-free Assays
- SKI-606 (Bosutinib) Sigma (1076180)? Try a better option.
- SKI-606 (Bosutinib) APExBIO (A2149)? Try a better option.
- SKI-606 (Bosutinib) Cayman (12030)? Try a better option.
- SKI-606 (Bosutinib) MedChemExpress (HY-10158)? Try a better option.
- SKI-606 (Bosutinib) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.