Cell-free Assays (IC50/Ki) for SKI-606 (Bosutinib)
| Key Target | IC50 (Cell-free) | Description | Reference |
|---|---|---|---|
| Abl kinase | 26 nM | Not explicitly mentioned in the text, values from Table 1. | PMC6544596 |
| DDR1/2 kinases | > 4900 nM | Not explicitly mentioned in the text, values from Table 1. | PMC6544596 |
| Src kinase | 1 nM | Not explicitly mentioned in the text, values from Table 1. | PMC6544596 |
Cell-based Assay (IC50) for SKI-606 (Bosutinib)
| Cell Type | IC50 (Cell-based) | Description | Reference |
|---|---|---|---|
| ORL-196 | 0.75 ± 0.03 μM | MTT assay | Download PDF |
| ORL-204 | 0.90 ± 0.04 μM | MTT assay | Download PDF |
| ORL-48 | 1.19 ± 0.05 μM | MTT assay | Download PDF |
| HSC-4 | 1.82 ± 0.03 μM | MTT assay | Download PDF |
| MCF7 | 12.22 ± 1.32 μM | MTT assay | Download PDF |
| P falciparum 3D7 | 0.34 μM | SYBR Green I DNA stain with flow cytometry | PMC12143834 |
| Vero cells | 7.0 μg/ml | CPE reduction | PMC9116211 |
| K562DOX | 36.1 nM | Tritiated thymidine incorporation assay, evaluated by a 1450 MicroBeta Trilux β-counter. Non-linear regression was used to evaluate IC50s. | Download PDF |
| K562 | 2.57 nM | eSimoa assay | PMC7472518 |
| BV-173 | 22.0 nM | 3H-thymidine incorporation | Download PDF |
| Z-119 | 86.9 nM | 3H-thymidine incorporation | Download PDF |
| SUP-B15 | 706.5 nM | 3H-thymidine incorporation | Download PDF |
| NCI-H460 | 1.43 µM | SRB assay | Download PDF |
| NCI-H460/R | 1.68 µM | SRB assay | Download PDF |
| A549 | 1.12 µM | SRB assay | Download PDF |
| A549-CDR1 | 2.89 µM | SRB assay | Download PDF |
Check the
SKI-606 (Bosutinib)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
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- SKI-606 (Bosutinib) Mechanism of Action: BCR-Abl Inhibition in Leukemia Cell Research
- SKI-606 (Bosutinib) Clinical Trials
- SKI-606 (Bosutinib) Working Concentration | Cell Culture | Treatment
- SKI-606 (Bosutinib) Solubility in DMSO
- SKI-606 (Bosutinib) Stock Solution
- SKI-606 (Bosutinib) Storage
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- SKI-606 (Bosutinib) Combination Database
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- SKI-606 (Bosutinib) Chemical Structure (2D and 3D)
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