Clinical Trials

Numerous clinical trials evaluate the therapeutic utility of bicalutamide, administered alone or combined with targeted agents, across various stages of prostate cancer, advanced or metastatic breast cancer, and renal cell carcinoma. Spanning early phase 1 through phase 4, these studies are sponsored by academic and medical institutions. The overall research landscape reflects diverse recruitment statuses, including completed, currently recruiting, terminated, and not yet recruiting studies.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04513717 ACTIVE_NOT_RECRUITING
Prostate Adenocarcinoma; Stage III Prostate Cancer AJCC v8; Stage IVA Prostate Cancer AJCC v8
NRG Oncology
2021-01-21 PHASE3
NCT07455903 RECRUITING
Prostate Cancer; Localized Prostate Carcinoma
Baptist Health South Florida
2026-07-29 PHASE2
NCT06650579 RECRUITING
Recurrent Prostate Carcinoma; Stage III Prostate Cancer AJCC v8; Stage IVA Prostate Cancer AJCC v8
Emory University
2025-01-31 PHASE3
NCT05979389 RECRUITING
NAFLD; PCOS
University of California, San Francisco
2024-02-14 PHASE1
NCT06145308 RECRUITING
Salivary Gland Carcinoma; Precision Therapy
Peking Union Medical College
2023-08-15 PHASE2
NCT05521698 RECRUITING
Non-Muscle Invasive Bladder Urothelial Carcinoma; Recurrent Non-Muscle Invasive Bladder Urothelial Carcinoma
University of Wisconsin, Madison
2026-06-25 PHASE1
NCT03678025 RECRUITING
Castration Levels of Testosterone; Metastatic Prostatic Adenocarcinoma; Stage IV Prostate Cancer AJCC v8; Stage IVA Prostate Cancer AJCC v8; Stage IVB Prostate Cancer AJCC v8
SWOG Cancer Research Network
2018-09-24 PHASE3
NCT07117851 RECRUITING
Extramammary Paget Disease; Scrotum Disease
Fudan University
2025-08-01 PHASE2
NCT06365788 RECRUITING
Triple Negative Breast Neoplasms
Universitaire Ziekenhuizen KU Leuven
2024-04-08 PHASE2
NCT04025372 ACTIVE_NOT_RECRUITING
Prostate Cancer
Brigham and Women's Hospital
2020-06-01 PHASE2
NCT04734730 RECRUITING
Castration-Sensitive Prostate Carcinoma; Metastatic Prostate Adenocarcinoma; Stage IV Prostate Cancer AJCC v8; Stage IVA Prostate Cancer AJCC v8; Stage IVB Prostate Cancer AJCC v8
City of Hope Medical Center
2021-05-04 PHASE2
NCT07593079 NOT_YET_RECRUITING
Prostate Cancer; Recurrent Prostate Cancer; Metastatic Prostate Cancer; Prostate Cancer Recurrent; Prostate Cancer Metastatic
Washington University School of Medicine
2026-07-31 PHASE2
NCT05095207 RECRUITING
Breast Cancer; Metastasis
Icahn School of Medicine at Mount Sinai
2021-09-20 PHASE1; PHASE2
NCT07783282 NOT_YET_RECRUITING
Prostate Cancer
Astellas Pharma Global Development, Inc.
2026-08-31 PHASE1
NCT04943536 ACTIVE_NOT_RECRUITING
Prostate Adenocarcinoma
Alessa Therapeutics Inc.
2021-12-07 PHASE1
NCT02531516 ACTIVE_NOT_RECRUITING
Prostatic Neoplasms
Aragon Pharmaceuticals, Inc.
2015-11-19 PHASE3
NCT01786265 ACTIVE_NOT_RECRUITING
Prostate Adenocarcinoma; Recurrent Prostate Carcinoma
M.D. Anderson Cancer Center
2013-02-05 PHASE2
NCT07393867 RECRUITING
Intermediate Risk Prostate Cancer; High Risk Prostate Cancer; Prostate Cancer
Martin T. King, MD, PhD
2026-04-29 PHASE2
NCT05050084 ACTIVE_NOT_RECRUITING
Prostate Adenocarcinoma
NRG Oncology
2021-12-06 PHASE3
NCT02605486 ACTIVE_NOT_RECRUITING
Metastatic Breast Cancer (MBC)
Memorial Sloan Kettering Cancer Center
2015-11-11 PHASE1; PHASE2
NCT03458221 RECRUITING
Recurrent Ovarian Cancer; Signal Transduction Pathway Deregulation; Therapy-Associated Cancer
Gynaecologisch Oncologisch Centrum Zuid
2023-01-31 PHASE2; PHASE3
NCT03090165 ACTIVE_NOT_RECRUITING
Triple Negative Breast Cancer
Kari Wisinski
2018-05-07 PHASE1; PHASE2
NCT04787744 RECRUITING
Prostate Cancer; Oligometastasis; Oligorecurrence; Recurrent Prostate Cancer; Metastatic Prostate Cancer; De Novo Prostate Cancer
VA Office of Research and Development
2021-07-01 PHASE2; PHASE3
NCT05327647 RECRUITING
Non-Muscle Invasive Bladder Cancer
CHU de Quebec-Universite Laval
2022-06-23 PHASE2
NCT06222593 RECRUITING
Carcinoma, Renal Cell
State University of New York at Buffalo
2024-10-01 PHASE1; PHASE2
NCT06528210 WITHDRAWN
High Risk Prostate Carcinoma; Localized Prostate Adenocarcinoma; Stage I Prostate Cancer AJCC v8; Stage II Prostate Cancer AJCC v8; Stage III Prostate Cancer AJCC v8
OHSU Knight Cancer Institute
2025-04-16 PHASE2
NCT05019846 RECRUITING
Prostate Cancer
Marco Lorenzo Bonu
2021-09-30 PHASE3
NCT03070886 COMPLETED
Stage I Prostate Adenocarcinoma AJCC v7; Stage II Prostate Adenocarcinoma AJCC v7; Stage III Prostate Adenocarcinoma AJCC v7
NRG Oncology
2017-04-05 PHASE2; PHASE3
NCT05513365 RECRUITING
Salivary Duct Carcinoma
Radboud University Medical Center
2022-09-27 PHASE2
NCT06501911 WITHDRAWN
Recurrent Glioblastoma; Recurrent High-grade Glioma
University of Nebraska
2025-04-08 PHASE1
NCT03141671 UNKNOWN
Prostate Cancer
Dana-Farber Cancer Institute
2017-11-24 PHASE2
NCT05647356 UNKNOWN
Polycystic Ovary Syndrome; Androgen Excess; Metabolic Disease
Royal College of Surgeons, Ireland
2023-01-01
NCT06222593 Not yet recruiting
Carcinoma Renal Cell
State University of New York at Buffalo
2024-06-01 Phase 1|Phase 2
NCT06018116 WITHDRAWN
Metastatic Urothelial Carcinoma
CHU de Quebec-Universite Laval
2023-11-07 PHASE2
NCT01969578 COMPLETED
Salivary Gland Cancer
European Organisation for Research and Treatment of Cancer - EORTC
2015-09-24 PHASE2
NCT03541928 RECRUITING
High-risk Prostate Cancer; Prostate Cancer
The Methodist Hospital Research Institute
2018-08-02 PHASE2
NCT04284761 COMPLETED
Prostate Adenocarcinoma; Lower Urinary Tract Symptoms
Alessa Therapeutics Inc.
2020-10-11 PHASE1
NCT03520478 UNKNOWN
Prostate Cancer; Hormone-Dependent Prostate Cancer
Jiangsu HengRui Medicine Co., Ltd.
2018-05-30 PHASE3
NCT03809000 ACTIVE_NOT_RECRUITING
Prostate Cancer
RTOG Foundation, Inc.
2019-04-15 PHASE2
NCT04049747 COMPLETED
Prostate Cancer; Non-metastatic Prostate Cancer; Prostate Adenocarcinoma
Imperial College London
2019-12-11
NCT03650894 ACTIVE_NOT_RECRUITING
Breast Neoplasm Female; Breast Cancer; Breast Carcinoma; Breast Tumor
Providence Health & Services
2019-04-03 PHASE2
NCT02299999 ACTIVE_NOT_RECRUITING
Metastatic Breast Cancer
UNICANCER
2014-04-07 PHASE2
NCT03971110 TERMINATED
Advanced Prostate Cancer
AstraZeneca
2021-01-28 PHASE4
NCT03043807 COMPLETED
Prostate Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
2017-02-22 PHASE2
NCT00541047 COMPLETED
Gastrointestinal Complications; Prostate Cancer; Sexual Dysfunction; Urinary Complications
University College, London
2007-11 PHASE3
NCT03147196 WITHDRAWN
Stage I Prostate Adenocarcinoma; Stage II Prostate Adenocarcinoma
Mayo Clinic
2017-06-27 PHASE2
NCT04248621 UNKNOWN
Prostatic Neoplasms
Wonju Severance Christian Hospital
2020-01-23 PHASE4
NCT02716974 COMPLETED
Prostate Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
2016-06 PHASE2
NCT00188708 COMPLETED
Prostatic Neoplasms
University Health Network, Toronto
2001-04
NCT01809691 COMPLETED
Prostate Cancer
SWOG Cancer Research Network
2013-03-08 PHASE3
NCT04374279 WITHDRAWN
COVID-19; SARS-CoV 2
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
2021-04 PHASE2
NCT02346253 COMPLETED
Prostate Adenocarcinoma; Stage I Prostate Cancer; Stage IIA Prostate Cancer; Stage IIB Prostate Cancer; Stage III Prostate Cancer
Stanford University
2015-01-13
NCT04652765 TERMINATED
Covid19; SARS-CoV Infection; Coronavirus Infection
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
2021-02-03 PHASE1
NCT03358563 COMPLETED
Prostate Cancer
University of Wisconsin, Madison
2018-01-17 EARLY_PHASE1
NCT03587285 UNKNOWN
Prostatic Neoplasms
Guangzhou University of Traditional Chinese Medicine
2018-09-23 PHASE1; PHASE2
NCT04509999 WITHDRAWN
COVID-19
University of Florida
2020-10-26 PHASE3
NCT00468715 COMPLETED
Breast Cancer
Memorial Sloan Kettering Cancer Center
2007-03-23 PHASE2
NCT04573231 Recruiting
Breast Cancer|HER2-negative Breast Cancer|Metastatic Breast Cancer
University of Wisconsin Madison
2021-05-24 Phase 2
NCT02058706 COMPLETED
Adenocarcinoma of the Prostate; Recurrent Prostate Cancer; Stage IV Prostate Cancer
Barbara Ann Karmanos Cancer Institute
2014-05 PHASE2
NCT02742675 UNKNOWN
Prostate Cancer
Fudan University
2015-09 PHASE2
NCT03878524 TERMINATED
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Anatomic Stage IV Breast Cancer AJCC v8; Anemia; Ann Arbor Stage III Hodgkin Lymphoma; Ann Arbor Stage III Non-Hodgkin Lymphoma; Ann Arbor Stage IV Hodgkin Lymphoma; Ann Arbor Stage IV Non-Hodgkin Lymphoma; Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Castration-Resistant Prostate Carcinoma; Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Hematopoietic and Lymphoid System Neoplasm; Locally Advanced Pancreatic Adenocarcinoma; Metastatic Breast Carcinoma; Metastatic Malignant Solid Neoplasm; Metastatic Pancreatic Adenocarcinoma; Myelodysplastic/Myeloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosis; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Primary Myelofibrosis; Recurrent Acute Lymphoblastic Leukemia; Recurrent Acute Myeloid Leukemia; Recurrent Chronic Lymphocytic Leukemia; Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Recurrent Hematologic Malignancy; Recurrent Hodgkin Lymphoma; Recurrent Myelodysplastic Syndrome; Recurrent Myelodysplastic/Myeloproliferative Neoplasm; Recurrent Myeloproliferative Neoplasm; Recurrent Non-Hodgkin Lymphoma; Recurrent Plasma Cell Myeloma; Recurrent Small Lymphocytic Lymphoma; Refractory Acute Lymphoblastic Leukemia; Refractory Acute Myeloid Leukemia; Refractory Chronic Lymphocytic Leukemia; Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Refractory Chronic Myelomonocytic Leukemia; Refractory Hematologic Malignancy; Refractory Hodgkin Lymphoma; Refractory Malignant Solid Neoplasm; Refractory Myelodysplastic Syndrome; Refractory Myelodysplastic/Myeloproliferative Neoplasm; Refractory Non-Hodgkin Lymphoma; Refractory Plasma Cell Myeloma; Refractory Primary Myelofibrosis; Refractory Small Lymphocytic Lymphoma; Stage II Pancreatic Cancer AJCC v8; Stage III Pancreatic Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8; Stage IV Prostate Cancer AJCC v8; Unresectable Pancreatic Adenocarcinoma
OHSU Knight Cancer Institute
2020-04-01 PHASE1
NCT03055312 TERMINATED
Metastatic Triple Negative Breast Cancer
Sun Yat-sen University
2016-12-20 PHASE3
NCT00936390 COMPLETED
Prostate Cancer
Radiation Therapy Oncology Group
2009-09 PHASE3
NCT04443062 Recruiting
Prostate Cancer
Radboud University Medical Center|Prostaatkankerstichting|Advanced Accelerator Applications
2020-07-20 Phase 2
NCT01342367 ACTIVE_NOT_RECRUITING
Prostate Cancer
University of Chicago
2010-12-17
NCT02918968 COMPLETED
Prostate Cancer
Astellas Pharma Inc
2016-11-02 PHASE4
NCT02614859 COMPLETED
Cancer of Prostate
Fox Chase Cancer Center
2015-12-01 PHASE2
NCT02458716 COMPLETED
Metastatic Prostate Carcinoma; Metastatic Prostatic Adenocarcinoma; Prostate Carcinoma Metastatic to the Bone
Rutgers, The State University of New Jersey
2015-03-06 PHASE1
NCT02697032 COMPLETED
Breast Cancer
University Medical Center Groningen
2016-02 PHASE2
NCT00866554 COMPLETED
Prostate Cancer; Erectile Dysfunction; Lower Urinary Tract Symptoms
CHU de Quebec-Universite Laval
2009-03 PHASE2
NCT02346578 COMPLETED
Castration-resistant Prostate Cancer
Taro Iguchi, MD, PHD
2014-12 PHASE2
NCT02910050 UNKNOWN
Breast Cancer
Xu fei
2016-01 PHASE2
NCT01251861 COMPLETED
Recurrent Prostate Carcinoma; Stage I Prostate Cancer AJCC v7; Stage IIA Prostate Cancer AJCC v7; Stage IIB Prostate Cancer AJCC v7; Stage III Prostate Cancer AJCC v7
National Cancer Institute (NCI)
2011-03-17 PHASE2
NCT02615223 UNKNOWN
Stage IV Prostate Cancer
Tianjin Medical University Cancer Institute and Hospital
2015-11
NCT02605226 UNKNOWN
Stage III Prostate Cancer
Tianjin Medical University Cancer Institute and Hospital
2015-11
NCT02487823 TERMINATED
Non Castrate Metastatic Prostate Cancer
Institut Paoli-Calmettes
2014-10 PHASE1
NCT02582749 TERMINATED
Prostate Cancer; Bone Metastases; Prostate Neoplasms
Ajjai Alva, MD
2016-04 PHASE2
NCT02059213 COMPLETED
Prostate Cancer
University of Michigan Rogel Cancer Center
2014-06 PHASE2
NCT00004124 COMPLETED
Prostate Cancer
SWOG Cancer Research Network
1999-10-15 PHASE3
NCT02353988 UNKNOWN
Breast Neoplasms
Jinling Hospital, China
2015-01 PHASE2
NCT02085252 COMPLETED
Prostate Cancer
Takeda
2013-06-03 PHASE3
NCT02910050 Unknown status
Breast Cancer
Xu fei|Sun Yat-sen University
2016-01 Phase 2
NCT01658527 WITHDRAWN
Prostate Cancer
European Organisation for Research and Treatment of Cancer - EORTC
2014-01 PHASE2
NCT02348281 TERMINATED
Breast Cancer
Fudan University
2015-01 PHASE2
NCT00814788 COMPLETED
Prostate Cancer
University of California, Davis
2008-12 PHASE2
NCT00002874 COMPLETED
Prostate Cancer
Radiation Therapy Oncology Group
1998-02 PHASE3
NCT00486642 COMPLETED
Hormone-Resistant Prostate Cancer; Recurrent Prostate Carcinoma
National Cancer Institute (NCI)
2007-09 PHASE2
NCT01420250 COMPLETED
Prostate Cancer
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
2011-09-22 PHASE1
NCT01120236 COMPLETED
Prostate Adenocarcinoma; Recurrent Prostate Carcinoma; Stage IV Prostate Cancer
National Cancer Institute (NCI)
2010-12 PHASE2
NCT02146937 WITHDRAWN
Detectable Prostate Nodules
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
2014-03 PHASE2
NCT00878436 COMPLETED
Prostate Cancer; Prostatic Neoplasms
NYU Langone Health
2009-06 PHASE1; PHASE2
NCT01664923 COMPLETED
Prostate Cancer
Pfizer
2012-08 PHASE2
NCT00776594 COMPLETED
Prostate Cancer
Dana-Farber Cancer Institute
2008-10 PHASE2
NCT01288911 COMPLETED
Prostatic Neoplasms
Astellas Pharma Inc
2011-03-22 PHASE2
NCT00658697 COMPLETED
Prostate Cancer
Dana-Farber Cancer Institute
2008-06 PHASE2
NCT01642732 TERMINATED
Prostate Cancer
University of Michigan Rogel Cancer Center
2012-10 PHASE1
NCT00528866 COMPLETED
Prostate Cancer
Radiation Therapy Oncology Group
2008-04 PHASE2
NCT00924807 TERMINATED
Prostate Cancer
Beth Israel Medical Center
2008-09 PHASE1; PHASE2
NCT00846976 COMPLETED
Prostate Cancer
AstraZeneca
1994-12 PHASE3
NCT00002651 COMPLETED
Prostate Cancer
SWOG Cancer Research Network
1995-05 PHASE3
NCT00470834 COMPLETED
Neoplasms, Prostate
GlaxoSmithKline
2007-05 PHASE4
NCT00943956 COMPLETED
Prostate Cancer
Institut du Cancer de Montpellier - Val d'Aurelle
2009-01 PHASE1
NCT00514917 TERMINATED
Prostatic Neoplasms
Sanofi
2007-07 PHASE3
NCT01200810 TERMINATED
Adenocarcinoma of the Prostate; Recurrent Prostate Cancer; Stage IV Prostate Cancer
National Cancer Institute (NCI)
2010-08 PHASE2
NCT00630344 COMPLETED
Prostate Cancer
Dana-Farber Cancer Institute
2008-02 PHASE2
NCT01050842 COMPLETED
Prostate Cancer; Adenocarcinoma of the Prostate; Hormone-resistant Prostate Cancer; Stage IV Prostate Cancer
Mayo Clinic
2010-02 EARLY_PHASE1
NCT01020305 TERMINATED
Prostate Cancer; Prostatic Neoplasms; Castrate-resistant Prostate Cancer (CRPC); Androgen-insensitive Prostate Cancer; Hormone-refractory Prostate Cancer; Metastatic Disease
Sandy Srinivas
2009-10 PHASE1; PHASE2
NCT00757692 COMPLETED
Prostate Cancer
British Columbia Cancer Agency
2009-01 PHASE2
NCT00002633 COMPLETED
Prostate Cancer
NCIC Clinical Trials Group
1995-02-08 PHASE3
NCT00833248 COMPLETED
Prostate Cancer
Ferring Pharmaceuticals
2009-04 PHASE3
NCT00702923 TERMINATED
Prostate Cancer
University of Wisconsin, Madison
2008-07 PHASE1
NCT00769795 COMPLETED
Prostate Cancer
University of Washington
2008-10 PHASE2
NCT00666666 COMPLETED
Adenocarcinoma of the Prostate; Stage IV Prostate Cancer
National Cancer Institute (NCI)
2009-07 PHASE2
NCT00777959 COMPLETED
Prostate Cancer
Merck Sharp & Dohme LLC
2008-10 PHASE2
NCT00170157 COMPLETED
Prostate Adenocarcinoma; Prostate Carcinoma; Recurrent Prostate Carcinoma; Stage III Prostate Cancer; Stage IV Prostate Cancer
Mayo Clinic
2004-06 PHASE2
NCT00388804 TERMINATED
Prostate Cancer
M.D. Anderson Cancer Center
2005-02 PHASE3
NCT00544830 ACTIVE_NOT_RECRUITING
PSA Level Greater Than Two; Stage IV Prostate Adenocarcinoma AJCC v7
City of Hope Medical Center
2006-07-18 PHASE2
NCT00884273 COMPLETED
Prostate Cancer
Ferring Pharmaceuticals
2009-08 PHASE3
NCT00099086 COMPLETED
Prostate Cancer
Medical University of South Carolina
2007-01-16 PHASE1
NCT00055731 COMPLETED
Prostate Cancer
UNICANCER
2002-11-14 PHASE3
NCT01416870 TERMINATED
Healthy
AstraZeneca
2010-07 PHASE1
NCT00659438 COMPLETED
Prostate Cancer
Genzyme, a Sanofi Company
2008-02 PHASE2
NCT00003653 COMPLETED
Prostate Cancer
NCIC Clinical Trials Group
1999-01-05 PHASE3
NCT00108732 COMPLETED
Recurrent Prostate Carcinoma; Stage I Prostate Cancer; Stage IIA Prostate Cancer; Stage IIB Prostate Cancer; Stage III Prostate Cancer
National Cancer Institute (NCI)
2006-02 PHASE2
NCT01416883 TERMINATED
Healthy
AstraZeneca
2010-07 PHASE1
NCT00430235 COMPLETED
Adenocarcinoma of the Prostate
British Columbia Cancer Agency
2007-03 PHASE2
NCT00298155 COMPLETED
Cancer; Prostate Neoplasms
University of Washington
2006-07 PHASE2
NCT00831233 TERMINATED
Prostate Cancer
Ferring Pharmaceuticals
2009-04 PHASE3
NCT00028769 COMPLETED
Prostate Cancer
SWOG Cancer Research Network
2001-12 PHASE2
NCT00589472 COMPLETED
Prostate Adenocarcinoma; Stage I Prostate Cancer; Stage IIA Prostate Cancer; Stage IIB Prostate Cancer; Stage III Prostate Cancer
National Cancer Institute (NCI)
2007-11 PHASE2
NCT00685633 WITHDRAWN
Prostate Cancer
Eastern Cooperative Oncology Group
2008-12 PHASE2
NCT00651326 TERMINATED
Prostate Cancer
NCIC Clinical Trials Group
2008-06-02 PHASE3
NCT00004054 COMPLETED
Prostate Cancer
Radiation Therapy Oncology Group
2000-01 PHASE3
NCT00482807 COMPLETED
Prostate Cancer
University of Nebraska
2004-08-31 PHASE1
NCT00554086 COMPLETED
Prostate Cancer
Canadian Urology Research Consortium
2005-11 PHASE2
NCT02382094 COMPLETED
Prostate Cancer
Karolinska University Hospital
2005-06 PHASE3
NCT00586898 COMPLETED
Prostate; Cancer; Hormonal Cycling
Memorial Sloan Kettering Cancer Center
2001-07 PHASE2
NCT00328614 COMPLETED
Prostate Cancer
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
2003-03 PHASE1
NCT00521781 TERMINATED
Prostatic Neoplasms
The Methodist Hospital Research Institute
2007-08 PHASE2
NCT00673205 COMPLETED
Non-Metastatic Prostate Cancer
AstraZeneca
1995-09 PHASE3
NCT00657904 COMPLETED
Non-metastatic Prostate Cancer
AstraZeneca
1995-08 PHASE3
NCT00094328 COMPLETED
Puberty, Precocious
AstraZeneca
2004-11-22 PHASE2
NCT00021450 COMPLETED
Prostate Cancer
European Organisation for Research and Treatment of Cancer - EORTC
2001-04 PHASE3
NCT00512668 TERMINATED
Adenocarcinoma of the Prostate; Recurrent Prostate Cancer
National Cancer Institute (NCI)
2007-09 PHASE1
NCT00233610 COMPLETED
Prostate Cancer
AstraZeneca
2003-12 PHASE3
NCT00244920 WITHDRAWN
Prostate Cancer
OHSU Knight Cancer Institute
2002-01 PHASE2
NCT00959335 COMPLETED
Prostate Cancer; Hirsutism
Sandoz
2006-08 PHASE1
NCT00960310 COMPLETED
Prostate Cancer; Hirsutism
Sandoz
2006-06 PHASE1
NCT00684905 COMPLETED
Prostate Cancer
Mayo Clinic
2000-04 PHASE2
NCT01044706 COMPLETED
Healthy
Kremers Urban Development Company
2005-05 PHASE1
NCT00002855 COMPLETED
Prostate Cancer
M.D. Anderson Cancer Center
1996-08 PHASE3
NCT01039233 COMPLETED
Bioequivalency
Kremers Urban Development Company
2005-05 PHASE1
NCT00030654 COMPLETED
Prostate Cancer
Radiation Therapy Oncology Group
2002-10 PHASE3
NCT00067015 COMPLETED
Prostate Cancer
Memorial Sloan Kettering Cancer Center
2003-05 PHASE3
NCT00023829 COMPLETED
Prostate Cancer
Radiation Therapy Oncology Group
2001-08 PHASE3
NCT00012090 COMPLETED
Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer
Memorial Sloan Kettering Cancer Center
2000-09 PHASE2
NCT00086736 COMPLETED
Prostate Cancer
University of Alabama at Birmingham
2001-11 PHASE2
NCT00973050 COMPLETED
Healthy
Teva Pharmaceuticals USA
2003-09 PHASE1
NCT00972855 COMPLETED
Healthy
Teva Pharmaceuticals USA
2003-09 PHASE1
NCT00014586 TERMINATED
Prostate Cancer
European Organisation for Research and Treatment of Cancer - EORTC
2001-01 PHASE3
NCT00031889 COMPLETED
Prostate Cancer
Swiss Cancer Institute
2001-08 PHASE2
NCT00026377 COMPLETED
Prostate Cancer
University of Chicago
2001-11 PHASE1
NCT00003026 COMPLETED
Prostate Cancer
European Organisation for Research and Treatment of Cancer - EORTC
1997-04 PHASE3
NCT00841113 COMPLETED
Prostate Cancer
Speciality European Pharma Limited
1999-01 PHASE3
NCT00421694 COMPLETED
Prostate Cancer
University of L'Aquila
PHASE2; PHASE3
NCT00255268 WITHDRAWN
Metastatic Prostate Cancer
AstraZeneca
2004-08 PHASE4
NCT00075192 COMPLETED
Prostatic Neoplasms
AstraZeneca
2004-03 PHASE1; PHASE2
NCT00672282 COMPLETED
Non-Metastatic Prostate Cancer
AstraZeneca
1995-10 PHASE3
NCT00551044 COMPLETED
Prostatic Neoplasms
Wirral University Teaching Hospital NHS Trust
2003-08
NCT00348998 UNKNOWN
Prostate Cancer
Virginia Mason Hospital/Medical Center
2006-04 PHASE2
NCT00536653 COMPLETED
Osteoporosis
Wirral University Teaching Hospital NHS Trust
1999-10
NCT00418080 COMPLETED
Prostate Cancer
University of L'Aquila
2002-04 PHASE2
NCT00349557 COMPLETED
Prostate Cancer
Benaroya Research Institute
2006-04 PHASE2
NCT00319787 COMPLETED
Locally Advanced Prostate Cancer
AstraZeneca
2003-12 PHASE2
NCT00771017 WITHDRAWN
Prostate Cancer
Eastern Cooperative Oncology Group
2008-07 PHASE2
NCT00293696 COMPLETED
Prostate Cancer
Tampere University
2004-10 PHASE4
NCT00003517 WITHDRAWN
Adenocarcinoma of the Prostate; Stage III Prostate Cancer; Stage IV Prostate Cancer; Recurrent Prostate Cancer
Burzynski Research Institute
PHASE2

(data from https://clinicaltrials.gov, updated on 2026-08-17)

Check the Bicalutamide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Bicalutamide acts as a competitive non-steroidal antagonist that selectively binds to the androgen receptor, suppressing downstream transcription of androgen-responsive genes, accelerating receptor degradation, and inducing cellular autophagy. By inhibiting androgen-mediated signaling pathways and reducing receptor availability, bicalutamide blocks tumor cell proliferation, providing therapeutic relevance in androgen-dependent malignancies such as prostate cancer and androgen receptor-positive breast cancer.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

Note: Technical data last updated: Sep 1, 2026.