CAS No. 5593-20-4

Batch: Purity:99.80
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Betamethasone Dipropionate Chemical Structure
Chemical Structure
Check the Betamethasone Dipropionate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 5593-20-4
Molecular Formula

C28H37FO7
Molecular Weight (MW) 504.59
SMILES CCC(=O)OCC(=O)C1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)OC(=O)CC

Ordering Information

Biological Activity

Betamethasone Dipropionate is a synthetic glucocorticoid receptor agonist with anti-inflammatory and immunosuppressive properties. It mimics endogenous cortisol by binding to glucocorticoid receptors, thereby modulating nuclear factor-kappa B (NF-kB) and activator protein 1 (AP-1) transcription factor pathways. This activation inhibits the transcription of pro-inflammatory cytokines and mediators while promoting anti-inflammatory gene expression, ultimately suppressing immune cell activation and inflammatory responses. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (198.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.