CAS No. 86541-74-4
| CAS Number | 86541-74-4 | |
|---|---|---|
| Molecular Formula |
C24H28N2O5.HCl |
|
| Molecular Weight (MW) | 460.95 | |
| SMILES | CCOC(=O)C(CCC1=CC=CC=C1)NC2CCC3=CC=CC=C3N(C2=O)CC(=O)O.Cl |
Benazepril HCl is a prodrug of benazeprilat, functioning as an angiotensin-converting enzyme (ACE) inhibitor within the renin-angiotensin-aldosterone system (RAAS). Upon hepatic cleavage, benazepril is converted to its active metabolite benazeprilat, which directly inhibits ACE activity. This inhibition blocks the conversion of angiotensin I to angiotensin II, leading to decreased aldosterone secretion, reduced vascular resistance, and attenuation of downstream signaling.
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
92 mg/mL
(199.58 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 92 mg/mL |
| Water | 27 mg/mL |
| DMSO |
92 mg/mL
(199.58 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 92 mg/mL |
| Water | 19 mg/mL |
| DMSO |
92 mg/mL
(199.58 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 92 mg/mL |
| Water | 19 mg/mL |
| DMSO |
92 mg/mL
(199.58 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 92 mg/mL |
| Water | 19 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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