Atropine sulfate monohydrate Clinical Trials

Size	Price	Qty
10mg	USD 147

Clinical Trials

Atropine sulfate monohydrate has been evaluated across numerous clinical trials spanning Early Phase I through Phase IV, alongside non-interventional studies. Sponsored by academic medical centers, specialized eye foundations, and healthcare companies, these studies focus on ophthalmic disorders such as pediatric myopia progression and amblyopia, as well as systemic indications including anesthesia premedication and organophosphorus poisoning management. Globally, these investigations encompass active, recruiting, completed, terminated, and withdrawn recruitment statuses.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05667454	RECRUITING	Progressive Myopia	Erasmus Medical Center	2022-12-19	PHASE3
NCT06765603	NOT_YET_RECRUITING	Myopia	Singapore National Eye Centre	2025-02-01	PHASE2
NCT07095894	RECRUITING	Myopia	Jaeb Center for Health Research	2026-06-01	PHASE3
NCT07567040	RECRUITING	Myopia	Ohio State University	2026-05-27	PHASE3
NCT07434635	RECRUITING	Eye Disorders	University of California, San Francisco	2026-03-10	PHASE4
NCT05815784	ACTIVE_NOT_RECRUITING	Myopia	Ann & Robert H Lurie Children's Hospital of Chicago	2023-05-02	PHASE2
NCT07028827	RECRUITING	Myopia	Ocus Innovation Ireland Limited	2025-09-01	PHASE3
NCT07271875	NOT_YET_RECRUITING	Postoperative Gastrointestinal Dysfunction (POGD); Postoperative Ileus; Colorectal Surgery	Xijing Hospital	2026-01-01	PHASE3
NCT06389110	RECRUITING	Myopia; Myopia, Progressive	Laboratorios Sophia S.A de C.V.	2025-03-15	PHASE3
NCT07164092	NOT_YET_RECRUITING	Myopia	Mansoura University	2025-09	PHASE2; PHASE3
NCT07329777	RECRUITING	Myopia Progression	IDB VisionCare SDN BHD	2025-09-17	PHASE3
NCT07756359	NOT_YET_RECRUITING	Pouch, Ileal; Pouches, Ileoanal; Bowel Diseases, Inflammatory	University of North Carolina, Chapel Hill	2026-09	PHASE4
NCT07364370	NOT_YET_RECRUITING	Pediatric Cataract; IOL Implantation; Myopia Progression	Cairo University	2026-02
NCT07475585	NOT_YET_RECRUITING	Myopia; Ear Acupressure Pellets; Hyperopia Reserve; Low-concentration Atropine Eye Drops; Eye Axis	Fangbiao Tao	2026-03-30
NCT07449247	NOT_YET_RECRUITING	Pre-myopia	Tianjin Medical University Eye Hospital	2026-03-30	PHASE1; PHASE2
NCT07129889	NOT_YET_RECRUITING	Myopia	Ningbo Eye Hospital	2025-12-02
NCT07176949	RECRUITING	Myopia; Pre-myopia	Shanghai Eye Disease Prevention and Treatment Center	2025-06-01
NCT07367178	NOT_YET_RECRUITING	Breast Cancer; Advanced HR+/HER2- Breast Cancer; Advanced Triple-Negative Breast Cancer	MedSIR	2026-07	PHASE2
NCT06912048	RECRUITING	Autonomic Function	University of Ulm	2025-05-14
NCT04770610	ACTIVE_NOT_RECRUITING	Myopia, Progressive	Ocumension (Hong Kong) Limited	2021-04-01	PHASE3
NCT05379855	RECRUITING	Exotropia; Exophoria; Myopia	Eye & ENT Hospital of Fudan University	2024-03-02
NCT06824025	RECRUITING	Post-Dural Puncture Headache	Minia University	2025-02-20	EARLY_PHASE1
NCT06667037	ACTIVE_NOT_RECRUITING	Myopia	Zhongshan Ophthalmic Center, Sun Yat-sen University	2024-09-21
NCT07724210	NOT_YET_RECRUITING	Myopia; Prevention and Control	Beijing Tongren Hospital	2026-08-20
NCT06708156	RECRUITING	Myopia; Myopia Progression	Oupushifang Pharmaceutical Technology Co., Ltd.	2024-06-15	PHASE3
NCT07537166	ENROLLING_BY_INVITATION	Acupressure	China Medical University Hospital	2026-04-11
NCT06579287	ACTIVE_NOT_RECRUITING	Myopia, Progressive	Sunhawk Vision Biotech, Inc.	2025-01-22	PHASE2
NCT06282848	RECRUITING	Myopia	The Hong Kong Polytechnic University	2024-01-01
NCT07777835	RECRUITING	Organophosphate Poisoning	Muhammad Aamir Latif	2026-05-10
NCT04641702	RECRUITING	Achalasia	Emory University	2021-03-17	PHASE4
NCT00992901	RECRUITING	Post Bariatricsurgery; Hypoglycemia	The University of Texas Health Science Center at San Antonio	2009-10	EARLY_PHASE1
NCT02823665	RECRUITING	Post Bariatric Surgery; Gastric Bypass; Sleeve Gastrectomy; Hypoglycemia After Gastric Bypass	The University of Texas Health Science Center at San Antonio	2015-07	EARLY_PHASE1
NCT05331664	RECRUITING	Rhegmatogenous Retinal Detachment	Massachusetts Eye and Ear Infirmary	2022-07-25	PHASE4
NCT07666984	RECRUITING	Neuromuscular Blockade Reversal Agent	Cukurova University	2026-06-04	PHASE4
NCT07676981	RECRUITING	Epiphora	Rehan Ahmed	2026-06	PHASE2
NCT06200194	ACTIVE_NOT_RECRUITING	Myopia; Preschool	National Yang Ming Chiao Tung University Hospital	2024-10-06	PHASE2
NCT06450132	ACTIVE_NOT_RECRUITING	Myopia	Ohio State University	2024-08-01	PHASE4
NCT06358755	ACTIVE_NOT_RECRUITING	Myopia	The Hong Kong Polytechnic University	2024-07-12
NCT07626892	COMPLETED	Myopia Progression; Atropine	Khyber Medical College, Peshawar	2024-06-03	PHASE3
NCT07614113	COMPLETED	Myopia; Progressive Myopia; Refractive Errors	University of Faisalabad	2025-02-17
NCT07456488	RECRUITING	Focus on Axial Length	Liaquat National Hospital & Medical College	2025-07-13	PHASE2
NCT06523504	RECRUITING	Myopia	Ruihua Wei	2024-02-01	PHASE1; PHASE2
NCT04923841	COMPLETED	Myopia	The Hong Kong Polytechnic University	2021-09-09
NCT05065424	COMPLETED	Respiratory Distress Syndrome, Newborn	University of Texas Southwestern Medical Center	2022-04-06	PHASE4
NCT07519226	COMPLETED	Shock	Lihua Wen	2024-05-08
NCT07268586	COMPLETED	Myocardial Infarction	Ain Shams University	2025-08-01	PHASE4
NCT05062031	COMPLETED	Myopia	Fondation Ophtalmologique Adolphe de Rothschild	2021-10-19
NCT07253428	ACTIVE_NOT_RECRUITING	Emergence Agitation; Nasal Surgery	Ain Shams University	2025-10-30
NCT05803863	UNKNOWN	Myopia	University of Medicine and Pharmacy at Ho Chi Minh City	2023-04-15	PHASE4
NCT06265454	UNKNOWN	Myopia Progression; Axial Length, Eye; Sclera Thickness	Ain Shams University	2024-09-01	PHASE2
NCT06922097	COMPLETED	Intraoperative Bradycardia	University of Hamburg-Eppendorf	2025-04-07
NCT06034379	RECRUITING	Myopia	Kubota Vision Inc.	2023-10-01
NCT07406399	COMPLETED	High Myopia; Low Concentration Atropine; Soft Contact Lens; Children	Beijing Tongren Hospital	2023-06-30	PHASE4
NCT06729047	NOT_YET_RECRUITING	Post-Dural Puncture Headache	Assiut University	2024-12-15	PHASE1; PHASE2
NCT03865160	ACTIVE_NOT_RECRUITING	Myopia, Progressive	University Eye Hospital, Freiburg	2021-10-19	PHASE2; PHASE3
NCT06082388	UNKNOWN	Cardiac Arrhythmia; Supraventricular Arrhythmia	Medical University of Lodz	2023-11-09
NCT07092046	COMPLETED	Minimal Flow Anesthesia; General Anaesthesia; Inhalation Anesthesia; Infection Risk; Anesthesia Circuit; Microbial Colonization; Anesthesia Equipment Bacterial Contamination	Ankara City Hospital Bilkent	2025-08-01
NCT02858310	COMPLETED	Papillomavirus Infections; Cervical Intraepithelial Neoplasia; Carcinoma In Situ; Vulvar Neoplasms; Vulvar Diseases	National Cancer Institute (NCI)	2017-01-27	PHASE1; PHASE2
NCT06865677	TERMINATED	Recurrent Platinum Resistant Epithelial Ovarian Carcinoma; Recurrent Epithelial Endometrial Carcinoma; Recurrent Epithelial Cervical Carcinoma	National Cancer Institute (NCI)	2025-06-09	PHASE2
NCT02078336	UNKNOWN	Dental Care for Disabled	Universitaire Ziekenhuizen KU Leuven	2013-12	PHASE4
NCT06431841	ACTIVE_NOT_RECRUITING	Myopia	Hospital San Carlos, Madrid	2022-02-23	PHASE4
NCT06034366	UNKNOWN	Myopia	He Eye Hospital	2023-10-01
NCT06209320	ACTIVE_NOT_RECRUITING	Myopia	Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.	2022-03-15	PHASE3
NCT05560542	COMPLETED	Morphine Adverse Reaction	Assiut University	2022-10-01
NCT06794450	RECRUITING	Neuromuscular Blocking Agents; Reversal of Neuromuscular Blockade; Recovery Time	Universitas Padjadjaran	2024-11-05	PHASE1; PHASE2
NCT06493838	UNKNOWN	Acute Pain	Minia University	2024-07-15	PHASE4
NCT04393103	WITHDRAWN	Organophosphorus Poisoning	Amani Hassan Abdel-Wahab	2024-04-01	PHASE2; PHASE3
NCT03140358	ACTIVE_NOT_RECRUITING	Myopia	Singapore National Eye Centre	2017-04-21	PHASE3
NCT05597163	UNKNOWN	Myopia, Progressive	Shanghai Eye Disease Prevention and Treatment Center	2023-01-15
NCT03942419	TERMINATED	Myopia	Eyenovia Inc.	2019-06-03	PHASE3
NCT06029530	WITHDRAWN	Myopia	Ohio State University	2024-01-01	PHASE1
NCT04699357	COMPLETED	High Myopia	Shanghai Eye Disease Prevention and Treatment Center	2021-07-04
NCT06327399	COMPLETED	Dexmedetomidine; Intubation Complication	Kasr El Aini Hospital	2024-04-01	PHASE2
NCT06344429	UNKNOWN	Myopia	Essilor-Polylite Taiwan Co., Ltd.	2023-08-20
NCT05203432	UNKNOWN	Myopia	Shanghai Eye Disease Prevention and Treatment Center	2022-02-10
NCT06174935	UNKNOWN	Vitreous Floaters	Jeanette Du	2024-01-01	PHASE2
NCT06210165	UNKNOWN	Atelectasis, Postoperative; Pulmonary Function; Newborn, Abnormal	Rhendra Hardy Mohamad Zaini	2022-12-07
NCT04173780	TERMINATED	Myopia Progressing; Childhood	University Hospital, Strasbourg, France	2020-02-12	PHASE2; PHASE3
NCT06366087	COMPLETED	Atropine Bioequivalence	Biomedical Advanced Research and Development Authority	2024-04-15	PHASE1
NCT03911271	COMPLETED	Myopia	Line Kessel	2019-05-30	PHASE2
NCT06291363	Not yet recruiting	Opioid Use Unspecified\|Anesthesia\|Nociceptive Pain	Ciusss de L''Est de l''Île de Montréal	2024-04-04	Phase 4
NCT05939882	UNKNOWN	Myopia, Progressive	Shanghai Eye Disease Prevention and Treatment Center	2023-04-01
NCT06263946	Recruiting	Myopia	Essilor International	2024-03-22	Not Applicable
NCT03690089	ACTIVE_NOT_RECRUITING	Myopia	Belfast Health and Social Care Trust	2019-04-03	PHASE2
NCT05666219	WITHDRAWN	Complete Heart Block; Inferior Wall Myocardial Infarction	National Institute of Cardiovascular Diseases, Pakistan	2022-12-19	PHASE4
NCT06071260	UNKNOWN	Myopia, Progressive	He Eye Hospital	2023-12-01
NCT05448989	UNKNOWN	Myopia	Shanghai Eye Disease Prevention and Treatment Center	2022-01-01	PHASE4
NCT05892913	COMPLETED	Pregnancy; Cesarean Section; Anesthesia, Spinal	Abant Izzet Baysal University	2023-07-19	PHASE4
NCT06697522	COMPLETED	Myopia	Ocumension Therapeutics (Suzhou) Co., Ltd	2023-06-25	PHASE3
NCT03030417	COMPLETED	Solid Tumors; Lymphoma	National Cancer Institute (NCI)	2017-02-27	PHASE1
NCT06111352	COMPLETED	Organophosphorus Poisoning	Sir Salimullah Medical College Mitford Hospital	2022-06-01	PHASE2
NCT04391361	UNKNOWN	Amyotrophic Lateral Sclerosis; Respiratory Function; Scopolamine	Ruijin Hospital	2020-11-01	PHASE2
NCT03909165	COMPLETED	Neuromuscular Blockade	Merck Sharp & Dohme LLC	2019-07-23	PHASE4
NCT06727019	COMPLETED	Myopia	Beijing Tongren Hospital	2023-04-10
NCT05478356	UNKNOWN	Myopia	Evidence Based Cataract Study Group	2022-08-01
NCT06209281	ACTIVE_NOT_RECRUITING	Myopia	Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.	2022-05-13	PHASE3
NCT05357326	UNKNOWN	Myopia	Shanghai Eye Disease Prevention and Treatment Center	2021-07-01	PHASE4
NCT05164367	COMPLETED	Cerebral Palsy; Sialorrhea	University of Utah	2022-10-01	EARLY_PHASE1
NCT05529056	UNKNOWN	Myopia; Children	LitePharmTech Co., Ltd.	2022-05-25	PHASE3
NCT05855018	UNKNOWN	Pharmacokinetics	Zhaoke (Hong Kong) Ophthalmology Pharmaceutical Limited	2023-05-09	PHASE1
NCT05006638	UNKNOWN	Pesticide Poisoning	Aya Sabry Mohamed Mohamed	2022-12	PHASE4
NCT05658380	COMPLETED	Anesthesia	Ain Shams University	2022-12-25	PHASE3
NCT05481489	WITHDRAWN	Myopia	Laboratorios Sophia S.A de C.V.	2023-02-01	PHASE1
NCT05449015	UNKNOWN	Accomodation; Refractive Errors; Myopia; Cycloplegia	Shanghai Eye Disease Prevention and Treatment Center	2020-12-22	PHASE4
NCT05372991	COMPLETED	Myopia, Progressive	Cloudbreak Therapeutics, LLC	2022-07-20	PHASE1; PHASE2
NCT05470881	COMPLETED	Myopia	Laboratorios Sophia S.A de C.V.	2022-08-20	PHASE1
NCT03094052	COMPLETED	HER2-positive Breast Cancer; Breast Adenocarcinoma; Stage II Breast Cancer AJCC v6 and v7; Stage IIA Breast Cancer AJCC v6 and v7; Stage IIB Breast Cancer AJCC v6 and v7; Stage III Breast Cancer AJCC v7; Stage IIIA Breast Cancer AJCC v7; Stage IIIB Breast Cancer AJCC v7; Stage IIIC Breast Cancer AJCC v7	University of California, San Francisco	2018-10-09	PHASE2
NCT07674966	COMPLETED	Myopia	University of California, Berkeley	2022-03-16	PHASE1
NCT06266962	COMPLETED	Intraoperative Floppy Iris Syndrome; Cataract; Age-related Cataract; Adrenergic Receptor Antagonist Adverse Reaction	University Hospital Olomouc	2020-07-01	PHASE4
NCT05199597	COMPLETED	Myopia	Ohio State University	2022-05-19	EARLY_PHASE1
NCT05137288	UNKNOWN	Perineal Surgery	Sohag University	2021-12-01
NCT03334253	COMPLETED	Myopia	Jaeb Center for Health Research	2018-06-01	PHASE3
NCT03508817	UNKNOWN	Myopia, Progressive	Sultan Qaboos University	2018-12-20	EARLY_PHASE1
NCT03754153	COMPLETED	Amblyopia	Moorfields Eye Hospital NHS Foundation Trust	2019-10-28
NCT04777383	TERMINATED	Cardiovascular Diseases; Vascular Diseases	University Hospital, Linkoeping	2019-04-01
NCT04910477	COMPLETED	Postdural Puncture Headache	Assiut University	2021-06-01	PHASE3
NCT04625088	COMPLETED	Healthy	SciMar Ltd.	2021-03-01
NCT04338373	UNKNOWN	Myopia	The V.P. Vyhodcev Eye Hospital	2020-02-17	PHASE3
NCT03972683	WITHDRAWN	Vasoconstriction; Vasodilation	Colorado State University	2019-04-16	EARLY_PHASE1
NCT03949101	UNKNOWN	Myopia	Shanghai Eye Disease Prevention and Treatment Center	2019-05-08	PHASE4
NCT02955927	COMPLETED	Myopia	The Hong Kong Polytechnic University	2016-11
NCT00748059	COMPLETED	Autonomic Nervous System Diseases; Orthostatic Hypotension; Dopamine Beta-Hydroxylase Deficiency; Orthostatic Intolerance	Vanderbilt University Medical Center	1996-12	PHASE1
NCT03984526	COMPLETED	Anesthesia, Spinal; Dexmedetomidine; Bradycardia	Ajou University School of Medicine	2019-06-25	PHASE4
NCT03312257	COMPLETED	Refractive Errors	Jenny Jones	2016-07
NCT06609993	COMPLETED	Aortic Aneurysm; Postoperative Nausea and Vomiting; Postoperative Pain; Haemodynamic Stability	Michał Stasiowski	2017-12-12
NCT04505228	COMPLETED	Hypertensive Heart Disease	Jun Xiao	2020-01-20
NCT04290039	COMPLETED	Toxic Effect of Organophosphate and Carbamate Insecticides	Biomedical Advanced Research and Development Authority	2020-01-04	PHASE1
NCT03351608	COMPLETED	Neuromuscular Blockade	Merck Sharp & Dohme LLC	2018-02-12	PHASE4
NCT03997006	COMPLETED	Post-Dural Puncture Headache	Damanhour Teaching Hospital	2019-01-01	PHASE4
NCT03374306	COMPLETED	Myopia	The Hong Kong Polytechnic University	2018-02-01
NCT03144453	UNKNOWN	Anesthesiology Management	Regina Elena Cancer Institute	2017-05-02	PHASE4
NCT02870478	COMPLETED	Myopia	University of California, Berkeley	2016-07	PHASE3
NCT02839668	COMPLETED	Breast Cancer	Iuliu Hatieganu University of Medicine and Pharmacy	2016-08	PHASE2
NCT03932578	COMPLETED	Nausea; Vomiting	Mansoura University	2019-05-05	PHASE4
NCT02743104	SUSPENDED	Paediatric Flexible Bronchoscopy	Rabin Medical Center	2016-05
NCT03638726	UNKNOWN	Cataract; Mydriasis; Adverse Drug Event	Dar El Oyoun Hospital	2018-09-28	PHASE4
NCT03544827	COMPLETED	Myopia	State University of New York College of Optometry	2018-05-21	PHASE4
NCT03690414	COMPLETED	Myopia	Hai Yen Eye Care	2018-10-01	PHASE1
NCT02927223	COMPLETED	Catecholaminergic Polymorphic Ventricular Tachycardia	Vanderbilt University	2016-10
NCT03593044	COMPLETED	Myopia	Jeffrey J. Walline, OD PhD	2018-07-23	PHASE1; PHASE2
NCT03580889	UNKNOWN	Lower Extremity Fracture	B.P. Koirala Institute of Health Sciences	2017-09-15	PHASE4
NCT03322150	TERMINATED	Spinal Anesthesia	Yonsei University	2017-10-01
NCT03322098	COMPLETED	Spinal Anesthesia	Yonsei University	2017-10-16
NCT03699423	COMPLETED	Myopia	Hai Yen Eye Care	2018-03-08	PHASE1
NCT03328312	UNKNOWN	Incidence of Postoperative Residual Curarization	Iuliu Hatieganu University of Medicine and Pharmacy	2017-12-01	EARLY_PHASE1
NCT04612998	COMPLETED	Obesity; Pregnancy Related; Cesarean Section Complications; Spinal Anaesthetic Poisoning of Undetermined Intent; Hypotension	Ataturk University	2017-02-01
NCT02455921	COMPLETED	Anesthesia; Functional	Attikon Hospital	2015-06	PHASE4
NCT02726620	COMPLETED	Hypotension	Vanderbilt University Medical Center	2017-01-05
NCT03158142	COMPLETED	Myopia	State University of New York College of Optometry	2017-03-15	PHASE4
NCT02939430	UNKNOWN	Blood Coagulation Tests ( INR, APTT)	Mansoura University	2016-11
NCT03387956	COMPLETED	Postoperative Nausea	Assiut University	2017-03-20
NCT02130167	COMPLETED	Myopia Progression	Chang Gung Memorial Hospital	2012-08
NCT02769325	UNKNOWN	Laparoscopic Surgery; Gynecology	Clinica Santa Maria	2016-05	PHASE4
NCT02698969	UNKNOWN	Post-operative Residual Curarization	University of Florence	2014-11	PHASE4
NCT02410590	WITHDRAWN	Neuromuscular Blockade	Merck Sharp & Dohme LLC	2015-07	PHASE4
NCT01490580	COMPLETED	Premedication; Endotracheal Intubation	Centre Hospitalier Intercommunal Creteil	2012-05	PHASE2; PHASE3
NCT02700893	COMPLETED	Premedication; Endotracheal Intubation; Cerebral Hypoperfusion	Centre Hospitalier Intercommunal Creteil	2016-03	PHASE2; PHASE3
NCT02361060	COMPLETED	Major Abdominal Surgery	Enrique Alday Muñoz	2015-02	PHASE4
NCT02622126	COMPLETED	Coagulation Defect; Bleeding	Assiut University	2016-01	PHASE2
NCT02676011	COMPLETED	Bradycardia	Assiut University	2016-02	PHASE2
NCT02445599	COMPLETED	Pain; Inadequate or Impaired Respiratory Function	University of Debrecen	2014-04	PHASE4
NCT01845636	COMPLETED	Mild Cognitive Impairment	New York State Psychiatric Institute	2012-08	PHASE4
NCT02327923	COMPLETED	Gall Stone Disease	B.P. Koirala Institute of Health Sciences	2015-01	PHASE4
NCT02522858	COMPLETED	Bradycardia	Sira Bang	2015-08	PHASE4
NCT03839888	COMPLETED	Myopia, Left Eye	Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation	2015-01-01
NCT01761552	UNKNOWN	Neuromuscular Blockade	Hadassah Medical Organization	2013-08	PHASE4
NCT02704923	COMPLETED	Ventilator-Associated Pneumonia	Universidade de Passo Fundo	2015-02	PHASE2
NCT02419352	COMPLETED	Post Operative Cognitive Dysfunction	Attikon Hospital	2010-09
NCT02160548	COMPLETED	Organophosphate Poisoning	Sylhet M.A.G.Osmani Medical College	2015-04	PHASE3
NCT07033442	COMPLETED	Anaesthesia; Intraocular Pressure; Trendelenburg Position; Robot Assisted Laparoscopic Radical Prostatectomy; Total Intravenous Anesthesia; Inhalation Anesthesia	Ataturk Training and Research Hospital	2015-07-23
NCT01951729	COMPLETED	Pre-diabetes	Washington University School of Medicine	2013-03-13	PHASE1
NCT02752308	COMPLETED	Hypospadias	Isfahan University of Medical Sciences	2014-09	PHASE2; PHASE3
NCT02228473	UNKNOWN	Catheter Site Discomfort; Complications; Anesthesia; Urinary Bladder Neoplasms	Seoul National University Hospital	2014-09
NCT02194088	COMPLETED	Pain	Brigham and Women's Hospital	2014-04	PHASE3
NCT02215382	COMPLETED	Intraocular Pressure Changes During Tracheal Extubation	Ordu University	2014-08	PHASE4
NCT02633579	COMPLETED	Healthy	Universitaire Ziekenhuizen KU Leuven	2012-10
NCT01595399	UNKNOWN	Bradycardia; Hypoxemia	University of Manitoba	2012-04	PHASE4
NCT02082054	UNKNOWN	Rhinitis, Seasonal, Allergic	Magna Pharmaceuticals, Inc.	2014-03	PHASE2
NCT00944710	COMPLETED	Amblyopia	Jaeb Center for Health Research	2009-08	PHASE3
NCT01871935	UNKNOWN	Haemodynamic Fluctuations During Off-pump CABG.	University Medical Center Groningen	2013-06
NCT01819064	COMPLETED	Bradycardia; Arrhythmias	State University of New York at Buffalo	2013-02	PHASE4
NCT02658721	COMPLETED	Anesthesia	Bagcilar Training and Research Hospital	2013-01	PHASE3
NCT01871922	COMPLETED	Anesthesia-induced Negative Hemodynamic Effects	University Medical Center Groningen	2012-10
NCT01539044	COMPLETED	Underdosing of Skeletal Muscle Relaxants for Laparotomy; Reversal of Skeletal Muscle Relaxant	Hospital Sultanah Aminah Johor Bahru	2012-02	PHASE4
NCT02186132	COMPLETED	Bradycardia; Neostigmine Adverse Reaction; Adverse Reaction to Belladonna or Atropine	Mahidol University	2012-03	PHASE4
NCT01534442	UNKNOWN	The Focus of This Study is to Evaluete the Significances of the Vagal Cholinerg Nervuos System for the Effect of GLP-1 by Using Atropin Administration.	University Hospital, Gentofte, Copenhagen	2011-09
NCT02055378	COMPLETED	Myopia	Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation	2011-01
NCT01422304	COMPLETED	Neuromuscular Blockade; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Blood Coagulation; Antithrombotic Agents	Merck Sharp & Dohme LLC	2011-10-12	PHASE3
NCT00251602	COMPLETED	Healthy	National Institute on Aging (NIA)	2003-03	PHASE1
NCT01427985	COMPLETED	Newborn; Preterm; Intubation	University of Ulm	2011-06	PHASE4
NCT00894179	TERMINATED	Coronary Artery Disease	Henry Ford Health System	2009-10
NCT01464489	COMPLETED	Intubation; Difficult	Gachon University Gil Medical Center	2011-05
NCT01191398	COMPLETED	Sialorrhea	Craig J. Huang	2010-06
NCT00998205	COMPLETED	Diastolic Dysfunction	University of Missouri-Columbia	2008-06
NCT00834470	COMPLETED	Conscious Sedation	Seoul National University Hospital	2008-08	PHASE4
NCT00991627	COMPLETED	Pregnancy; Cesarean Section; Anesthesia,Spinal; Hypotension	University of Parma	2009-09	PHASE4
NCT00947596	COMPLETED	Organophosphorus Poisoning	MicroDose Defense Products L.L.C.	2009-08	PHASE1
NCT00320892	TERMINATED	Noise; Death	Soroka University Medical Center	2007-01
NCT01858090	COMPLETED	Elective Caesarean Section Surgeries	Baskent University	2009-01	PHASE3
NCT00623207	COMPLETED	Chest Pain	HaEmek Medical Center, Israel	2007-12	PHASE3
NCT00724932	COMPLETED	Anesthesia, General	Merck Sharp & Dohme LLC	2008-07-16	PHASE3
NCT00506675	TERMINATED	Amblyopia	Jaeb Center for Health Research	2007-10	PHASE3
NCT00689208	COMPLETED	Insulin Resistance	AstraZeneca	2007-05	EARLY_PHASE1
NCT00121524	COMPLETED	Cardiac Arrest	Petter Andreas Steen	2003-01	PHASE2
NCT00921102	COMPLETED	Cesarean Section; Anesthesia,Spinal; Postoperative Nausea and Vomiting	University of Parma	2007-05	PHASE4
NCT00815048	COMPLETED	Endotracheal Intubation	King Saud University	2006-01	PHASE4
NCT00315328	COMPLETED	Amblyopia	Jaeb Center for Health Research	2005-08	PHASE3
NCT00315302	COMPLETED	Amblyopia	Jaeb Center for Health Research	2005-02	PHASE3
NCT00583323	COMPLETED	Lymphoma	Mayo Clinic	2003-02	PHASE3
NCT00000170	COMPLETED	Amblyopia	Jaeb Center for Health Research	1999-04	PHASE3
NCT00431392	COMPLETED	Regional Blood Flow; Ocular Physiology	Medical University of Vienna	2001-09	PHASE2
NCT00575523	COMPLETED	Arrhythmia; Respiratory Arrest	Medical University of Vienna	2003-10	PHASE4
NCT00001864	COMPLETED	Amblyopia; Anisometropia; Strabismus	National Eye Institute (NEI)	1999-05	PHASE3
NCT00328900	UNKNOWN	Hemorrhoids; Fissure in Ano	Rikshospitalet University Hospital	2006-01
NCT00094692	COMPLETED	Amblyopia	Jaeb Center for Health Research	2002-10	PHASE3
NCT00457717	COMPLETED	Myopia	China Medical University, China	2005-07	PHASE1
NCT00468091	COMPLETED	Digestive Physiology; Gastrointestinal Motility; Gastrointestinal Hormones; Glucagon-like Peptide 1; Exendin (9-39)	Ludwig-Maximilians - University of Munich	1999-02	PHASE1
NCT00541177	UNKNOWN	Myopia	Min-Sheng General Hospital	2007-04	PHASE4
NCT00371124	UNKNOWN	Myopia	Singapore National Eye Centre	2006-03	PHASE2; PHASE3
NCT00094614	COMPLETED	Amblyopia	Jaeb Center for Health Research	2002-06	PHASE4

(data from https://clinicaltrials.gov, updated on 2025-04-27)

Check the Atropine sulfate monohydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Atropine sulfate monohydrate competitively binds to muscarinic acetylcholine receptors, blocking cholinergic signal transduction and preventing downstream intracellular biochemical signaling cascades. This receptor blockade reduces parasympathetic tone to suppress airway secretions and relax ciliary muscles, directly underlying its therapeutic application in controlling pediatric myopia progression and serving as an anesthetic premedication in clinical trials.

Appendix RUO and cGMP Quality Standards

Quality Dimension	RUO (Research Use Only)	cGMP (Current Good Manufacturing Practice)
Clinical Applicability	Prohibited in human clinical trials or medical diagnostics.	Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status	Non-regulated grade; exempt from drug manufacturing laws.	Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment	Unclassified analytical or research laboratories.	Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control	Basic purity and activity testing.	Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation	Basic equipment calibration; no process validation required.	Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance	Vendor self-declared without required formal QMS.	Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact	High risk of IND rejection if used as a critical raw material.	Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).