CAS No. 229975-97-7

Batch: Purity:99.98
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Atazanavir (BMS-232632) Sulfate Chemical Structure
Chemical Structure
Check the Atazanavir (BMS-232632) Sulfate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name methyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[(4-pyridin-2-ylphenyl)methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate;sulfuric acid
CAS Number 229975-97-7
Molecular Formula

C38H52N6O7.H2SO4
Molecular Weight (MW) 802.93
SMILES CC(C)(C)C(C(=O)NC(CC1=CC=CC=C1)C(CN(CC2=CC=C(C=C2)C3=CC=CC=N3)NC(=O)C(C(C)(C)C)NC(=O)OC)O)NC(=O)OC.OS(=O)(=O)O
InChIKey DQSGVVGOPRWTKI-QVFAWCHISA-N

Biological Activity

Atazanavir sulfate is an HIV protease inhibitor targeting HIV-1 protease. It inhibits viral polyprotein processing in cell culture with an EC50 ranging from 2.6 to 5.3 nM. By blocking the proteolytic cleavage of the viral gag precursor p55, it prevents viral maturation and impairs human immunodeficiency virus replication while displaying minimal host cell cytotoxicity. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (124.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Robinson BS, et al. Antimicrob Agents Chemother. 2000;44(8):2093-9.

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Note: Technical data last updated: Sep 1, 2026.