CAS No. 88495-63-0
Batch:
Purity:99.56
Chemical Structure
Check the
Artesunate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-oxo-4-[[(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]oxy]butanoic acid | |
|---|---|---|
| CAS Number | 88495-63-0 | |
| Molecular Formula |
C19H28O8 |
|
| Molecular Weight (MW) | 384.42 | |
| InChIKey | FIHJKUPKCHIPAT-AHIGJZGOSA-N |
Biological Activity
Artesunate is a semi-synthetic artemisinin derivative and potent antimalarial agent that functions as an EXP1 inhibitor and STAT3 pathway modulator. It induces reactive oxygen species production, suppresses STAT3 signaling, and inhibits cancer cell proliferation, displaying selective cytotoxicity against small cell lung carcinoma H69 cells with an IC50 below. Furthermore, artesunate demonstrates antiparasitic efficacy and targeted toxicity toward malignant over normal cells. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
77 mg/mL
(200.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 77 mg/mL |
| Water | Insoluble |
| DMSO |
77 mg/mL
(200.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 9 mg/mL |
| Water | Insoluble |
| DMSO |
76 mg/mL
(197.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 76 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.