CAS No. 131707-23-8
| IUPAC Name | ethyl 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate;hydrochloride | |
|---|---|---|
| CAS Number | 131707-23-8 | |
| Molecular Formula |
C22H25BrN2O3S.HCl |
|
| Molecular Weight (MW) | 513.88 | |
| SMILES | CCOC(=O)C1=C(N(C2=CC(=C(C(=C21)CN(C)C)O)Br)C)CSC3=CC=CC=C3.Cl | |
| InChIKey | OMZHXQXQJGCSKN-UHFFFAOYSA-N |
Arbidol HCl (Umifenovir) is a broad-spectrum antiviral compound that acts as a viral entry inhibitor. It directly interacts with viral envelope glycoproteins, such as influenza hemagglutinin, as well as host membrane lipids to block viral entry and endosomal membrane fusion. By preventing early-stage virus-cell interactions, Arbidol suppresses viral replication and inhibits infection by various respiratory viruses, including influenza A and B strains. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(194.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 50 mg/mL |
| Water | Insoluble |
| DMSO |
103 mg/mL
(200.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 22 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(194.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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