CAS No. 161814-49-9

Batch: Purity:99.99
Check CoA
Amprenavir (VX-478) Chemical Structure
Chemical Structure
Check the Amprenavir (VX-478) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(3S)-oxolan-3-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate
CAS Number 161814-49-9
Molecular Formula

C25H35N3O6S
Molecular Weight (MW) 505.63
SMILES CC(C)CN(CC(C(CC1=CC=CC=C1)NC(=O)OC2CCOC2)O)S(=O)(=O)C3=CC=C(C=C3)N
InChIKey YMARZQAQMVYCKC-OEMFJLHTSA-N

Ordering Information

Biological Activity

Amprenavir (VX-478) is a potent HIV protease inhibitor (Ki 0.6 nM) and a selective PXR agonist. By binding directly to the active site of HIV protease, amprenavir interrupts the maturation phase of the viral replicative cycle by blocking the cleavage of viral polyproteins. This prevents the formation of infectious viral particles and suppresses viral replication in HIV-infected cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Ethanol 101 mg/mL
DMSO 30 mg/mL (59.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.