CAS No. 2016-88-8
| IUPAC Name | 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;hydrochloride | |
|---|---|---|
| CAS Number | 2016-88-8 | |
| Molecular Formula |
C6H8ClN7O.HCl |
|
| Molecular Weight (MW) | 266.09 | |
| SMILES | C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.Cl | |
| InChIKey | ACHKKGDWZVCSNH-UHFFFAOYSA-N |
Amiloride HCl is an epithelial sodium channel blocker, a selective T-type calcium channel blocker, and a selective urokinase plasminogen activator (uPA) inhibitor with a Ki of. By blocking sodium channels in renal epithelial cells, it inhibits sodium reabsorption and alters membrane potential, thereby reducing potassium and hydrogen ion secretion. Additionally, uPA inhibition suppresses pericellular proteolysis and extracellular matrix remodeling. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
53 mg/mL
(199.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 6 mg/mL |
| Ethanol | 5 mg/mL |
| DMSO |
53 mg/mL
(199.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 11 mg/mL |
| Ethanol | 3 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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