Clinical Trials

Allopurinol has been evaluated in numerous clinical trials spanning Early Phase 1 through Phase 4 investigations for indications including gout, cardiovascular conditions, acute kidney injury, ischemic stroke, mania, and leukemia. Conducted globally, these studies exhibit varied recruitment statuses, ranging from actively recruiting and completed to terminated or pending. Trial sponsors encompass major academic medical centers, healthcare systems, and biopharmaceutical companies.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04875702 RECRUITING
Gout
Massachusetts General Hospital
 2024-02-22 PHASE4
NCT04875702 RECRUITING
Gout
Massachusetts General Hospital
 2024-02-22 PHASE4
NCT05943821 RECRUITING
Cardiovascular Diseases; Uric Acid
Poznan University of Medical Sciences
 2023-09-01 PHASE3
NCT05943821 RECRUITING
Cardiovascular Diseases; Uric Acid
Poznan University of Medical Sciences
 2023-09-01 PHASE3
NCT05536349 RECRUITING
Leukemia
M.D. Anderson Cancer Center
 2022-12-20 PHASE2
NCT05536349 RECRUITING
Leukemia
M.D. Anderson Cancer Center
 2022-12-20 PHASE2
NCT07089888 RECRUITING
Tophaceous Gout
Crystalys Therapeutics
 2025-08-04 PHASE3
NCT07089888 RECRUITING
Tophaceous Gout
Crystalys Therapeutics
 2025-08-04 PHASE3
NCT07089875 RECRUITING
Gout
Crystalys Therapeutics
 2025-08-01 PHASE3
NCT07089875 RECRUITING
Gout
Crystalys Therapeutics
 2025-08-01 PHASE3
NCT07326839 NOT_YET_RECRUITING
Gout; Obesity
XueMei Guo
 2025-12-10
NCT07326839 NOT_YET_RECRUITING
Gout; Obesity
XueMei Guo
 2025-12-10
NCT05805605 RECRUITING
Acute Myelogenous Leukemia; Acute Lymphocytic Leukemia; Biphenotypic Acute Leukemia; Undifferentiated Leukemia; Prolymphocytic Leukemia; Chronic Myelogenous Leukemia; Plasma Cell Leukemia; Myelodysplastic Syndromes; Leukemia, Myeloid; Myelodysplastic Syndrome With Excess Blasts-1; Burkitt Lymphoma; Relapsed T-Cell Lymphoma; Relapsed Chronic Lymphocytic Leukemia; Small Lymphocytic Lymphoma; Marginal Zone Lymphoma; Follicular Lymphoma; Myeloproliferative Neoplasm; Myelofibrosis
Masonic Cancer Center, University of Minnesota
 2023-05-01 PHASE2
NCT05805605 RECRUITING
Acute Myelogenous Leukemia; Acute Lymphocytic Leukemia; Biphenotypic Acute Leukemia; Undifferentiated Leukemia; Prolymphocytic Leukemia; Chronic Myelogenous Leukemia; Plasma Cell Leukemia; Myelodysplastic Syndromes; Leukemia, Myeloid; Myelodysplastic Syndrome With Excess Blasts-1; Burkitt Lymphoma; Relapsed T-Cell Lymphoma; Relapsed Chronic Lymphocytic Leukemia; Small Lymphocytic Lymphoma; Marginal Zone Lymphoma; Follicular Lymphoma; Myeloproliferative Neoplasm; Myelofibrosis
Masonic Cancer Center, University of Minnesota
 2023-05-01 PHASE2
NCT07369622 NOT_YET_RECRUITING
Gout Initiating Urate-loweringUrate-lowering Therapy; Gout Arthritis; Gout and Hyperuricemia
Haiphong University of Medicine and Pharmacy
 2026-01-20 PHASE4
NCT07369622 NOT_YET_RECRUITING
Gout Initiating Urate-loweringUrate-lowering Therapy; Gout Arthritis; Gout and Hyperuricemia
Haiphong University of Medicine and Pharmacy
 2026-01-20 PHASE4
NCT07574060 RECRUITING
Depression
Tanta University
 2026-05-20 PHASE2; PHASE3
NCT07574060 RECRUITING
Depression
Tanta University
 2026-05-20 PHASE2; PHASE3
NCT03150693 RECRUITING
B Acute Lymphoblastic Leukemia
Alliance for Clinical Trials in Oncology
 2017-09-20 PHASE3
NCT03150693 RECRUITING
B Acute Lymphoblastic Leukemia
Alliance for Clinical Trials in Oncology
 2017-09-20 PHASE3
NCT07800598 RECRUITING
Cirrhoses, Liver; Decompensated Cirrhosis of Liver
Bangladesh Medical University
 2025-09-10 PHASE4
NCT04026776 RECRUITING
Salt; Excess; Blood Pressure Disorders
Wake Forest University Health Sciences
 2020-09-02 EARLY_PHASE1
NCT07800598 RECRUITING
Cirrhoses, Liver; Decompensated Cirrhosis of Liver
Bangladesh Medical University
 2025-09-10 PHASE4
NCT04026776 RECRUITING
Salt; Excess; Blood Pressure Disorders
Wake Forest University Health Sciences
 2020-09-02 EARLY_PHASE1
NCT04217421 RECRUITING
Congenital Heart Disease in Children; Neuroprotection
dr. M.J.N.L. Benders
 2020-02-14 PHASE3
NCT04217421 RECRUITING
Congenital Heart Disease in Children; Neuroprotection
dr. M.J.N.L. Benders
 2020-02-14 PHASE3
NCT07367971 RECRUITING
Gout Chronic; Gout; DDI (Drug-Drug Interaction)
Atom Therapeutics Co., Ltd
 2026-01-23 PHASE1
NCT07367971 RECRUITING
Gout Chronic; Gout; DDI (Drug-Drug Interaction)
Atom Therapeutics Co., Ltd
 2026-01-23 PHASE1
NCT05888233 COMPLETED
Heart Failure Preserved Ejection Fraction; Resistant Hypertension
VA Office of Research and Development
 2024-09-30 PHASE2
NCT05888233 COMPLETED
Heart Failure Preserved Ejection Fraction; Resistant Hypertension
VA Office of Research and Development
 2024-09-30 PHASE2
NCT03162653 UNKNOWN
Encephalopathy, Hypoxic-Ischemic; Infant, Newborn, Diseases
University Hospital Tuebingen
 2018-03-25 PHASE3
NCT03162653 UNKNOWN
Encephalopathy, Hypoxic-Ischemic; Infant, Newborn, Diseases
University Hospital Tuebingen
 2018-03-25 PHASE3
NCT05511766 COMPLETED
Cirrhosis; Hepatic Encephalopathy; Ascites; Varices; SBP - Spontaneous Bacterial Peritonitis
Tanta University
 2022-11-15 PHASE2; PHASE3
NCT05511766 COMPLETED
Cirrhosis; Hepatic Encephalopathy; Ascites; Varices; SBP - Spontaneous Bacterial Peritonitis
Tanta University
 2022-11-15 PHASE2; PHASE3
NCT05540184 UNKNOWN
AKI - Acute Kidney Injury
Beni-Suef University
 2022-09-19 PHASE4
NCT05540184 UNKNOWN
AKI - Acute Kidney Injury
Beni-Suef University
 2022-09-19 PHASE4
NCT05665699 COMPLETED
Gout
InventisBio Co., Ltd
 2023-04-17 PHASE2
NCT05665699 COMPLETED
Gout
InventisBio Co., Ltd
 2023-04-17 PHASE2
NCT05586971 COMPLETED
Gout; Hyperuricemia; Gout Flare; Tophi
LG Chem
 2023-03-30 PHASE3
NCT05586971 COMPLETED
Gout; Hyperuricemia; Gout Flare; Tophi
LG Chem
 2023-03-30 PHASE3
NCT05601271 COMPLETED
Chronic Kidney Diseases; Osteodystrophy; Uric Acid Concentration, Serum, Quantitative Trait Locus 7
University of Sao Paulo General Hospital
 2021-03-01
NCT05601271 COMPLETED
Chronic Kidney Diseases; Osteodystrophy; Uric Acid Concentration, Serum, Quantitative Trait Locus 7
University of Sao Paulo General Hospital
 2021-03-01
NCT05818085 COMPLETED
Gout
Atom Therapeutics Co., Ltd
 2023-08-11 PHASE2; PHASE3
NCT05818085 COMPLETED
Gout
Atom Therapeutics Co., Ltd
 2023-08-11 PHASE2; PHASE3
NCT05049863 TERMINATED
Small-cell Lung Cancer; Small Cell Lung Carcinoma
Washington University School of Medicine
 2023-02-27 PHASE1
NCT05049863 TERMINATED
Small-cell Lung Cancer; Small Cell Lung Carcinoma
Washington University School of Medicine
 2023-02-27 PHASE1
NCT04621929 COMPLETED
Obesity; Uric Acid Stones; Type 2 Diabetes Mellitus in Obese; Pre-Diabetes
University of Florida
 2021-03-31 PHASE2
NCT04621929 COMPLETED
Obesity; Uric Acid Stones; Type 2 Diabetes Mellitus in Obese; Pre-Diabetes
University of Florida
 2021-03-31 PHASE2
NCT07177898 COMPLETED
Diabetic Kidney Disease (DKD)
Narowal Medical College
 2023-05-14
NCT07177898 COMPLETED
Diabetic Kidney Disease (DKD)
Narowal Medical College
 2023-05-14
NCT06276556 TERMINATED
Gout
Atom Therapeutics Co., Ltd
 2024-04-22 PHASE2; PHASE3
NCT06276556 TERMINATED
Gout
Atom Therapeutics Co., Ltd
 2024-04-22 PHASE2; PHASE3
NCT05253833 COMPLETED
Gout; Arthritis, Gouty; Hyperuricemia; Gout Chronic
Arthrosi Therapeutics
 2022-08-12 PHASE2
NCT05253833 COMPLETED
Gout; Arthritis, Gouty; Hyperuricemia; Gout Chronic
Arthrosi Therapeutics
 2022-08-12 PHASE2
NCT06056570 COMPLETED
Gout; Hyperuricemia
Urica Therapeutics Inc.
 2023-10-04 PHASE1; PHASE2
NCT06056570 COMPLETED
Gout; Hyperuricemia
Urica Therapeutics Inc.
 2023-10-04 PHASE1; PHASE2
NCT03570983 UNKNOWN
Multiple Myeloma
Swedish Medical Center
 2018-09-05 PHASE2
NCT03570983 UNKNOWN
Multiple Myeloma
Swedish Medical Center
 2018-09-05 PHASE2
NCT02953509 TERMINATED
Non Hodgkin Lymphoma
Gilead Sciences
 2016-11-21 PHASE1; PHASE2
NCT02953509 TERMINATED
Non Hodgkin Lymphoma
Gilead Sciences
 2016-11-21 PHASE1; PHASE2
NCT07033533 COMPLETED
Cirrhoses, Liver
Tanta University
 2023-06-01 PHASE1; PHASE2
NCT07033533 COMPLETED
Cirrhoses, Liver
Tanta University
 2023-06-01 PHASE1; PHASE2
NCT04956432 COMPLETED
Gout
Jiangsu HengRui Medicine Co., Ltd.
 2021-06-15 PHASE3
NCT04956432 COMPLETED
Gout
Jiangsu HengRui Medicine Co., Ltd.
 2021-06-15 PHASE3
NCT02661035 COMPLETED
Acute Myelogenous Leukemia; Acute Lymphocytic Leukemia; Chronic Myelogenous Leukemia; Plasma Cell Leukemia; Myelodysplastic Syndromes; Chronic Lymphocytic Leukemia; Small Lymphocytic Lymphoma; B-Cell Lymphoma; Follicular Lymphoma; Lymphoplasmacytic Lymphoma; Mantle-Cell Lymphoma; Prolymphocytic Leukemia; Lymphoblastic Lymphoma; Burkitt's Lymphoma; Non-Hodgkin's Lymphoma; Multiple Myeloma; Myeloproliferative Syndromes; Hematological Diseases
Masonic Cancer Center, University of Minnesota
 2017-03-09 PHASE2
NCT02661035 COMPLETED
Acute Myelogenous Leukemia; Acute Lymphocytic Leukemia; Chronic Myelogenous Leukemia; Plasma Cell Leukemia; Myelodysplastic Syndromes; Chronic Lymphocytic Leukemia; Small Lymphocytic Lymphoma; B-Cell Lymphoma; Follicular Lymphoma; Lymphoplasmacytic Lymphoma; Mantle-Cell Lymphoma; Prolymphocytic Leukemia; Lymphoblastic Lymphoma; Burkitt's Lymphoma; Non-Hodgkin's Lymphoma; Multiple Myeloma; Myeloproliferative Syndromes; Hematological Diseases
Masonic Cancer Center, University of Minnesota
 2017-03-09 PHASE2
NCT05665699 Recruiting
Gout
InventisBio Co. Ltd
 2023-04-17 Phase 2
NCT05545670 COMPLETED
Cirrhosis
Tanta University
 2022-06-15 PHASE2; PHASE3
NCT05545670 COMPLETED
Cirrhosis
Tanta University
 2022-06-15 PHASE2; PHASE3
NCT05474560 COMPLETED
Non-Alcoholic Fatty Liver Disease; Hyperuricemia
Ain Shams University
 2022-01-01 PHASE4
NCT05474560 COMPLETED
Non-Alcoholic Fatty Liver Disease; Hyperuricemia
Ain Shams University
 2022-01-01 PHASE4
NCT05828836 COMPLETED
Cirrhosis, Liver
Tanta University
 2022-06-15 PHASE2; PHASE3
NCT05828836 COMPLETED
Cirrhosis, Liver
Tanta University
 2022-06-15 PHASE2; PHASE3
NCT03336203 UNKNOWN
Gout; CKD Stage 1-4; SUA Level (>8 mg/dL; 480 µmol/L)
Medical Practice Prof D. Ivanov
 2017-10-30 PHASE4
NCT03336203 UNKNOWN
Gout; CKD Stage 1-4; SUA Level (>8 mg/dL; 480 µmol/L)
Medical Practice Prof D. Ivanov
 2017-10-30 PHASE4
NCT03745729 COMPLETED
Acute Coronary Syndrome
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
 2019-03-01 PHASE4
NCT03745729 COMPLETED
Acute Coronary Syndrome
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
 2019-03-01 PHASE4
NCT03776656 COMPLETED
Adenylosuccinate Lyase Deficiency
Assistance Publique - Hôpitaux de Paris
 2019-10-14 PHASE2
NCT03776656 COMPLETED
Adenylosuccinate Lyase Deficiency
Assistance Publique - Hôpitaux de Paris
 2019-10-14 PHASE2
NCT05193838 Unknown status
Dilated Cardiomyopathy
Assiut University
 2022-05-01 --
NCT04327024 COMPLETED
Heart Failure With Preserved Ejection Fraction (HFpEF)
AstraZeneca
 2020-05-19 PHASE2
NCT04327024 COMPLETED
Heart Failure With Preserved Ejection Fraction (HFpEF)
AstraZeneca
 2020-05-19 PHASE2
NCT03648996 COMPLETED
Diabetes Mellitus, Type 2; Hyperuricemia
University of Missouri-Columbia
 2018-11-01 PHASE2
NCT03648996 COMPLETED
Diabetes Mellitus, Type 2; Hyperuricemia
University of Missouri-Columbia
 2018-11-01 PHASE2
NCT05360628 COMPLETED
Healthy
InventisBio Co., Ltd
 2021-11-01 EARLY_PHASE1
NCT05360628 COMPLETED
Healthy
InventisBio Co., Ltd
 2021-11-01 EARLY_PHASE1
NCT03990363 COMPLETED
Chronic Kidney Disease
AstraZeneca
 2019-07-23 PHASE2
NCT03990363 COMPLETED
Chronic Kidney Disease
AstraZeneca
 2019-07-23 PHASE2
NCT05360628 Completed
Healthy
InventisBio Co. Ltd
 2021-11-01 Early Phase 1
NCT04368819 UNKNOWN
Refractory Angina
Ministry of Health, Brazil
 2021-03-03 PHASE2; PHASE3
NCT04368819 UNKNOWN
Refractory Angina
Ministry of Health, Brazil
 2021-03-03 PHASE2; PHASE3
NCT04550234 COMPLETED
Chronic Kidney Disease
AstraZeneca
 2021-04-13 PHASE1
NCT04550234 COMPLETED
Chronic Kidney Disease
AstraZeneca
 2021-04-13 PHASE1
NCT04052932 COMPLETED
Gout
Jiangsu HengRui Medicine Co., Ltd.
 2019-07-16 PHASE3
NCT04052932 COMPLETED
Gout
Jiangsu HengRui Medicine Co., Ltd.
 2019-07-16 PHASE3
NCT04853615 Not yet recruiting
SGLT2i Kideny Protection Against Contrast in Diabetic Kidney
Fayoum University|Cairo University
 2021-07-01 --
NCT05414669 COMPLETED
Kidney Calculi
RSUP Prof. Dr. I.G.N.G. Ngoerahal
 2020-08-06 PHASE4
NCT05414669 COMPLETED
Kidney Calculi
RSUP Prof. Dr. I.G.N.G. Ngoerahal
 2020-08-06 PHASE4
NCT02579096 COMPLETED
Gout; Chronic Kidney Diseases
VA Office of Research and Development
 2017-03-06 PHASE4
NCT02579096 COMPLETED
Gout; Chronic Kidney Diseases
VA Office of Research and Development
 2017-03-06 PHASE4
NCT02122718 COMPLETED
Ischaemic Stroke
NHS Greater Glasgow and Clyde
 2014-05 PHASE4
NCT02122718 COMPLETED
Ischaemic Stroke
NHS Greater Glasgow and Clyde
 2014-05 PHASE4
NCT04532918 COMPLETED
Chronic Kidney Disease
AstraZeneca
 2020-09-10 PHASE1
NCT04532918 COMPLETED
Chronic Kidney Disease
AstraZeneca
 2020-09-10 PHASE1
NCT03865407 TERMINATED
Hyperuricemia; Chronic Kidney Diseases
Virginia Commonwealth University
 2019-03-10 PHASE2
NCT03865407 TERMINATED
Hyperuricemia; Chronic Kidney Diseases
Virginia Commonwealth University
 2019-03-10 PHASE2
NCT03353298 COMPLETED
Renal Transplant Donor of Left Kidney; Renal Transplant Donor of Right Kidney
Oslo University Hospital
 2018-01-17 PHASE2
NCT03353298 COMPLETED
Renal Transplant Donor of Left Kidney; Renal Transplant Donor of Right Kidney
Oslo University Hospital
 2018-01-17 PHASE2
NCT04155918 COMPLETED
Gout Patients
Arthrosi Therapeutics
 2020-02-03 PHASE2
NCT04155918 COMPLETED
Gout Patients
Arthrosi Therapeutics
 2020-02-03 PHASE2
NCT04256629 COMPLETED
Healthy Volunteers (Intended Indication: Chronic Kidney Disease)
AstraZeneca
 2020-03-03 PHASE1
NCT04256629 COMPLETED
Healthy Volunteers (Intended Indication: Chronic Kidney Disease)
AstraZeneca
 2020-03-03 PHASE1
NCT04012294 UNKNOWN
Musculoskeletal Degeneration; Inflammation; Hyperuricemia
Instituto Nacional de Cardiologia Ignacio Chavez
 2019-08-30 PHASE3
NCT04012294 UNKNOWN
Musculoskeletal Degeneration; Inflammation; Hyperuricemia
Instituto Nacional de Cardiologia Ignacio Chavez
 2019-08-30 PHASE3
NCT02046694 COMPLETED
Acute Lymphoblastic Leukemia (ALL)
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 2014-01-06 EARLY_PHASE1
NCT02046694 COMPLETED
Acute Lymphoblastic Leukemia (ALL)
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 2014-01-06 EARLY_PHASE1
NCT01685411 TERMINATED
Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Myelodysplastic Syndrome
Masonic Cancer Center, University of Minnesota
 2013-01
NCT01685411 TERMINATED
Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Myelodysplastic Syndrome
Masonic Cancer Center, University of Minnesota
 2013-01
NCT03680404 COMPLETED
Cardiovascular Diseases; Cardiovascular Risk Factor; Vasoconstriction
The University of Texas at Arlington
 2018-10-01 PHASE1
NCT03680404 COMPLETED
Cardiovascular Diseases; Cardiovascular Risk Factor; Vasoconstriction
The University of Texas at Arlington
 2018-10-01 PHASE1
NCT03700645 UNKNOWN
Diabetes Mellitus; Ischemic Heart Disease; Multi Vessel Coronary Artery Disease
Tel-Aviv Sourasky Medical Center
 2018-12-01 PHASE4
NCT03700645 UNKNOWN
Diabetes Mellitus; Ischemic Heart Disease; Multi Vessel Coronary Artery Disease
Tel-Aviv Sourasky Medical Center
 2018-12-01 PHASE4
NCT03101800 UNKNOWN
Colitis, Ulcerative; Colitis Ulcerative Exacerbation
Hvidovre University Hospital
 2016-12-14 PHASE3
NCT03101800 UNKNOWN
Colitis, Ulcerative; Colitis Ulcerative Exacerbation
Hvidovre University Hospital
 2016-12-14 PHASE3
NCT03767322 UNKNOWN
Contrast-induced Nephropathy; Contrast-induced Acute Kidney Injury
Instituto Nacional de Cardiologia Ignacio Chavez
 2018-12-05 PHASE2
NCT03767322 UNKNOWN
Contrast-induced Nephropathy; Contrast-induced Acute Kidney Injury
Instituto Nacional de Cardiologia Ignacio Chavez
 2018-12-05 PHASE2
NCT04347005 COMPLETED
Healthy Volunteers
Arthrosi Therapeutics
 2019-01-22 PHASE1
NCT04347005 COMPLETED
Healthy Volunteers
Arthrosi Therapeutics
 2019-01-22 PHASE1
NCT02017171 COMPLETED
Diabetic Nephropathies; Coronary Artery Disease
Alessandro Doria
 2014-02 PHASE3
NCT02017171 COMPLETED
Diabetic Nephropathies; Coronary Artery Disease
Alessandro Doria
 2014-02 PHASE3
NCT03836599 COMPLETED
Chronic Kidney Disease
AstraZeneca
 2019-01-16 PHASE1
NCT03836599 COMPLETED
Chronic Kidney Disease
AstraZeneca
 2019-01-16 PHASE1
NCT03076684 WITHDRAWN
Hyperuricemia
University of Missouri-Columbia
 2017-03-03 EARLY_PHASE1
NCT03601260 UNKNOWN
Gout
Hillel Yaffe Medical Center
 2018-08
NCT03076684 WITHDRAWN
Hyperuricemia
University of Missouri-Columbia
 2017-03-03 EARLY_PHASE1
NCT03022747 UNKNOWN
Lymphoblastic Leukemia, Acute, Childhood
Vastra Gotaland Region
 2017-01 PHASE2
NCT03601260 UNKNOWN
Gout
Hillel Yaffe Medical Center
 2018-08
NCT03022747 UNKNOWN
Lymphoblastic Leukemia, Acute, Childhood
Vastra Gotaland Region
 2017-01 PHASE2
NCT00899431 TERMINATED
Chronic Lymphocytic Leukemia
M.D. Anderson Cancer Center
 2009-05-06 PHASE2
NCT00899431 TERMINATED
Chronic Lymphocytic Leukemia
M.D. Anderson Cancer Center
 2009-05-06 PHASE2
NCT01332799 TERMINATED
Complications of Renal Transplant
Roberto S Kalil
 2011-02 PHASE4
NCT01332799 TERMINATED
Complications of Renal Transplant
Roberto S Kalil
 2011-02 PHASE4
NCT02038179 COMPLETED
Pre-hypertension; JNC 7 Stage I Hypertension
University of Alabama at Birmingham
 2014-07 PHASE2; PHASE3
NCT02038179 COMPLETED
Pre-hypertension; JNC 7 Stage I Hypertension
University of Alabama at Birmingham
 2014-07 PHASE2; PHASE3
NCT03680573 COMPLETED
Cardiovascular Diseases; Cardiovascular Risk Factor; Vasoconstriction
The University of Texas at Arlington
 2018-01-08 PHASE1
NCT03680573 COMPLETED
Cardiovascular Diseases; Cardiovascular Risk Factor; Vasoconstriction
The University of Texas at Arlington
 2018-01-08 PHASE1
NCT03506919 UNKNOWN
Treatment of Arthritis
Shifa Ul Mulk Memorial Hospital
 2018-01-01 PHASE1; PHASE2
NCT03506919 UNKNOWN
Treatment of Arthritis
Shifa Ul Mulk Memorial Hospital
 2018-01-01 PHASE1; PHASE2
NCT03385135 UNKNOWN
Diabetes Mellitus; Coronary Artery Disease
University Tunis El Manar
 2017-12
NCT02956278 COMPLETED
Chronic Gout; Hyperuricemia
University of California, San Francisco
 2016-11 PHASE4
NCT03385135 UNKNOWN
Diabetes Mellitus; Coronary Artery Disease
University Tunis El Manar
 2017-12
NCT02956278 COMPLETED
Chronic Gout; Hyperuricemia
University of California, San Francisco
 2016-11 PHASE4
NCT02129764 COMPLETED
Heart Failure, Hyperuricemia
Hebei Medical University
 2013-12 PHASE2; PHASE3
NCT02129764 COMPLETED
Heart Failure, Hyperuricemia
Hebei Medical University
 2013-12 PHASE2; PHASE3
NCT03046914 UNKNOWN
Stevens-Johnson Syndrome; Kidney Failure, Chronic
Seoul National University Hospital
 2016-02-24
NCT03046914 UNKNOWN
Stevens-Johnson Syndrome; Kidney Failure, Chronic
Seoul National University Hospital
 2016-02-24
NCT03680638 COMPLETED
Cardiovascular Diseases; Cardiovascular Risk Factor; Vasodilation
The University of Texas at Arlington
 2016-09-07 PHASE1
NCT03680638 COMPLETED
Cardiovascular Diseases; Cardiovascular Risk Factor; Vasodilation
The University of Texas at Arlington
 2016-09-07 PHASE1
NCT03272425 COMPLETED
Gout
Ardea Biosciences, Inc.
 2017-08-14 PHASE1
NCT03272425 COMPLETED
Gout
Ardea Biosciences, Inc.
 2017-08-14 PHASE1
NCT01550107 COMPLETED
Sarcopenia
University of Dundee
 2015-02-01 PHASE4
NCT01550107 COMPLETED
Sarcopenia
University of Dundee
 2015-02-01 PHASE4
NCT03195153 UNKNOWN
Diabetes Mellitus Type 2 Platelets Reactivity Statin
University of Roma La Sapienza
 2017-03-28 PHASE4
NCT03195153 UNKNOWN
Diabetes Mellitus Type 2 Platelets Reactivity Statin
University of Roma La Sapienza
 2017-03-28 PHASE4
NCT02237339 COMPLETED
Hypertension; Hypertrophy, Left Ventricular
University of Dundee
 2014-09 PHASE4
NCT02237339 COMPLETED
Hypertension; Hypertrophy, Left Ventricular
University of Dundee
 2014-09 PHASE4
NCT01101035 COMPLETED
Cardiovascular Disease
Takeda
 2010-04-23 PHASE3
NCT01101035 COMPLETED
Cardiovascular Disease
Takeda
 2010-04-23 PHASE3
NCT02500641 COMPLETED
Gout
Menarini International Operations Luxembourg SA
 2015-08-17 PHASE4
NCT02500641 COMPLETED
Gout
Menarini International Operations Luxembourg SA
 2015-08-17 PHASE4
NCT02373384 COMPLETED
Urolithiasis; Renal Stones
Mansoura University
 2015-02 PHASE4
NCT02373384 COMPLETED
Urolithiasis; Renal Stones
Mansoura University
 2015-02 PHASE4
NCT02888054 COMPLETED
Healthy
Ardea Biosciences, Inc.
 2016-08-30 PHASE1
NCT02888054 COMPLETED
Healthy
Ardea Biosciences, Inc.
 2016-08-30 PHASE1
NCT02797028 UNKNOWN
Cardiovascular Disease
Guangzhou General Hospital of Guangzhou Military Command
 2015-01 PHASE4
NCT02797028 UNKNOWN
Cardiovascular Disease
Guangzhou General Hospital of Guangzhou Military Command
 2015-01 PHASE4
NCT01228903 COMPLETED
Kidney Disease
University of Colorado, Denver
 2010-10
NCT01228903 COMPLETED
Kidney Disease
University of Colorado, Denver
 2010-10
NCT02829177 COMPLETED
Type 1 Diabetes; Diabetic Nephropathy
Peter Rossing
 2014-09 PHASE4
NCT02829177 COMPLETED
Type 1 Diabetes; Diabetic Nephropathy
Peter Rossing
 2014-09 PHASE4
NCT01808131 COMPLETED
Gout
Ardea Biosciences, Inc.
 2013-02 PHASE3
NCT01951404 COMPLETED
End Stage Renal Disease; Left Ventricular Hypertrophy
University of Dundee
 2013-09 PHASE4
NCT01808131 COMPLETED
Gout
Ardea Biosciences, Inc.
 2013-02 PHASE3
NCT01951404 COMPLETED
End Stage Renal Disease; Left Ventricular Hypertrophy
University of Dundee
 2013-09 PHASE4
NCT01200485 COMPLETED
Leukemia; Lymphoma
M.D. Anderson Cancer Center
 2011-04 PHASE2
NCT01987570 COMPLETED
Patients With Grade II Ankle Sprain
Instituto de Investigacion Sanitaria La Fe
 2012-04 PHASE3
NCT02581553 COMPLETED
Healthy
Ardea Biosciences, Inc.
 2015-10 PHASE1
NCT01200485 COMPLETED
Leukemia; Lymphoma
M.D. Anderson Cancer Center
 2011-04 PHASE2
NCT01987570 COMPLETED
Patients With Grade II Ankle Sprain
Instituto de Investigacion Sanitaria La Fe
 2012-04 PHASE3
NCT02581553 COMPLETED
Healthy
Ardea Biosciences, Inc.
 2015-10 PHASE1
NCT04983160 COMPLETED
Chronic Kidney Disease
Maimónides Biomedical Research Institute of Córdoba
 2014-02-26 PHASE2
NCT04983160 COMPLETED
Chronic Kidney Disease
Maimónides Biomedical Research Institute of Córdoba
 2014-02-26 PHASE2
NCT02700347 COMPLETED
Tuberculosis
National University Hospital, Singapore
 2016-02 PHASE1
NCT02700347 COMPLETED
Tuberculosis
National University Hospital, Singapore
 2016-02 PHASE1
NCT02533648 COMPLETED
Type 2 Diabetes Mellitus
Hospices Civils de Lyon
 2011-09-16 PHASE3
NCT02533648 COMPLETED
Type 2 Diabetes Mellitus
Hospices Civils de Lyon
 2011-09-16 PHASE3
NCT02498652 COMPLETED
Gout
Ardea Biosciences, Inc.
 2015-07-28 PHASE2
NCT02498652 COMPLETED
Gout
Ardea Biosciences, Inc.
 2015-07-28 PHASE2
NCT02477488 COMPLETED
Gout; Renal Insufficiency
Maisonneuve-Rosemont Hospital
 2015-06 PHASE4
NCT02477488 COMPLETED
Gout; Renal Insufficiency
Maisonneuve-Rosemont Hospital
 2015-06 PHASE4
NCT02398448 COMPLETED
Healthy
Ardea Biosciences, Inc.
 2015-04 PHASE1
NCT02398448 COMPLETED
Healthy
Ardea Biosciences, Inc.
 2015-04 PHASE1
NCT01637623 COMPLETED
Severe Obstructive Sleep Apnea (Apnea Hypopnea Index > 30 Events/Hour); Hypertension
University of Wisconsin, Madison
 2012-06 PHASE2
NCT01637623 COMPLETED
Severe Obstructive Sleep Apnea (Apnea Hypopnea Index > 30 Events/Hour); Hypertension
University of Wisconsin, Madison
 2012-06 PHASE2
NCT01564277 TERMINATED
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Blastic Phase Chronic Myelogenous Leukemia; Contiguous Stage II Adult Burkitt Lymphoma; de Novo Myelodysplastic Syndromes; Noncontiguous Stage II Adult Burkitt Lymphoma; Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Stage I Adult Burkitt Lymphoma; Stage III Adult Burkitt Lymphoma; Stage IV Adult Burkitt Lymphoma; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Adult Acute Myeloid Leukemia
Roswell Park Cancer Institute
 2011-09-29 PHASE2
NCT01564277 TERMINATED
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Blastic Phase Chronic Myelogenous Leukemia; Contiguous Stage II Adult Burkitt Lymphoma; de Novo Myelodysplastic Syndromes; Noncontiguous Stage II Adult Burkitt Lymphoma; Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Stage I Adult Burkitt Lymphoma; Stage III Adult Burkitt Lymphoma; Stage IV Adult Burkitt Lymphoma; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Adult Acute Myeloid Leukemia
Roswell Park Cancer Institute
 2011-09-29 PHASE2
NCT01320722 COMPLETED
Renal Function; Endothelial Function; Blood Pressure; Overweight; Obesity
Brigham and Women's Hospital
 2011-03 PHASE3
NCT02752633 COMPLETED
Adenine Phosphoribosyltransferase Deficiency
Landspitali University Hospital
 2013-05 PHASE4
NCT01320722 COMPLETED
Renal Function; Endothelial Function; Blood Pressure; Overweight; Obesity
Brigham and Women's Hospital
 2011-03 PHASE3
NCT02752633 COMPLETED
Adenine Phosphoribosyltransferase Deficiency
Landspitali University Hospital
 2013-05 PHASE4
NCT02279641 COMPLETED
Gout
Ardea Biosciences, Inc.
 2014-11-01 PHASE1
NCT02279641 COMPLETED
Gout
Ardea Biosciences, Inc.
 2014-11-01 PHASE1
NCT02078219 COMPLETED
Gout and Hyperuricemia
AstraZeneca
 2014-01-05 PHASE2
NCT02078219 COMPLETED
Gout and Hyperuricemia
AstraZeneca
 2014-01-05 PHASE2
NCT01457820 TERMINATED
Chronic Stable Angina
Stephen McSwiggan
 2012-04 PHASE4
NCT01457820 TERMINATED
Chronic Stable Angina
Stephen McSwiggan
 2012-04 PHASE4
NCT02063997 COMPLETED
Gout
Gilead Sciences
 2014-03 PHASE2
NCT02063997 COMPLETED
Gout
Gilead Sciences
 2014-03 PHASE2
NCT02600780 COMPLETED
Hyperuricemia
Getz Pharma
 2013-11 PHASE4
NCT02992652 COMPLETED
Endoscopic Retrograde Cholangiopancreatography
Ain Shams University
 2011-01
NCT02600780 COMPLETED
Hyperuricemia
Getz Pharma
 2013-11 PHASE4
NCT02992652 COMPLETED
Endoscopic Retrograde Cholangiopancreatography
Ain Shams University
 2011-01
NCT00602693 COMPLETED
Leukemia; Lymphoma; Multiple Myeloma; Plasma Cell Neoplasm; Myelodysplastic Syndromes
Masonic Cancer Center, University of Minnesota
 2007-07-23 PHASE1
NCT00602693 COMPLETED
Leukemia; Lymphoma; Multiple Myeloma; Plasma Cell Neoplasm; Myelodysplastic Syndromes
Masonic Cancer Center, University of Minnesota
 2007-07-23 PHASE1
NCT01510158 COMPLETED
Gout
Ardea Biosciences, Inc.
 2012-01 PHASE3
NCT02008968 UNKNOWN
Hyperuricemia; Prediabetes; Insulin Resistance
Istanbul Medeniyet University
 2013-12
NCT01510158 COMPLETED
Gout
Ardea Biosciences, Inc.
 2012-01 PHASE3
NCT02008968 UNKNOWN
Hyperuricemia; Prediabetes; Insulin Resistance
Istanbul Medeniyet University
 2013-12
NCT01493531 COMPLETED
Gout
Ardea Biosciences, Inc.
 2011-12 PHASE3
NCT01493531 COMPLETED
Gout
Ardea Biosciences, Inc.
 2011-12 PHASE3
NCT00987415 COMPLETED
Heart Failure; Elevated Serum Uric Acid
Duke University
 2010-05 PHASE2
NCT00987415 COMPLETED
Heart Failure; Elevated Serum Uric Acid
Duke University
 2010-05 PHASE2
NCT01464359 TERMINATED
Acute Myelogenous Leukemia; Refractory Acute Myelogenous Leukemia
Masonic Cancer Center, University of Minnesota
 2011-10 PHASE2
NCT02082769 COMPLETED
Gout
Xijing Hospital
 2011-07 PHASE3
NCT01724528 COMPLETED
Tumor Lysis Syndrome
Menarini Group
 2012-10 PHASE3
NCT01464359 TERMINATED
Acute Myelogenous Leukemia; Refractory Acute Myelogenous Leukemia
Masonic Cancer Center, University of Minnesota
 2011-10 PHASE2
NCT02082769 COMPLETED
Gout
Xijing Hospital
 2011-07 PHASE3
NCT01724528 COMPLETED
Tumor Lysis Syndrome
Menarini Group
 2012-10 PHASE3
NCT00281255 WITHDRAWN
Cardiovascular Diseases; Cardiomyopathy, Dilated; Heart Diseases; Heart Failure, Congestive
University of Pennsylvania
 2003-06 PHASE1; PHASE2
NCT01459796 TERMINATED
Gout
Regeneron Pharmaceuticals
 2011-11 PHASE3
NCT01988402 COMPLETED
Gout
59th Medical Wing
 2007-12 PHASE4
NCT00281255 WITHDRAWN
Cardiovascular Diseases; Cardiomyopathy, Dilated; Heart Diseases; Heart Failure, Congestive
University of Pennsylvania
 2003-06 PHASE1; PHASE2
NCT01988402 COMPLETED
Gout
59th Medical Wing
 2007-12 PHASE4
NCT01459796 TERMINATED
Gout
Regeneron Pharmaceuticals
 2011-11 PHASE3
NCT00513474 COMPLETED
Chronic Myeloproliferative Disorders; Graft Versus Host Disease; Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms
Massachusetts General Hospital
 2008-01 PHASE1
NCT00513474 COMPLETED
Chronic Myeloproliferative Disorders; Graft Versus Host Disease; Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms
Massachusetts General Hospital
 2008-01 PHASE1
NCT01391325 COMPLETED
Gout
Ardea Biosciences, Inc.
 2011-07 PHASE4
NCT01391325 COMPLETED
Gout
Ardea Biosciences, Inc.
 2011-07 PHASE4
NCT01775098 WITHDRAWN
Gout
Université de Sherbrooke
NCT01775098 WITHDRAWN
Gout
Université de Sherbrooke
NCT01609166 COMPLETED
Hand-foot Syndrome
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
 2011-07 PHASE2
NCT01609166 COMPLETED
Hand-foot Syndrome
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
 2011-07 PHASE2
NCT01451645 COMPLETED
Intercritical Gout
Regeneron Pharmaceuticals
 2011-10 PHASE4
NCT01451645 COMPLETED
Intercritical Gout
Regeneron Pharmaceuticals
 2011-10 PHASE4
NCT01265264 COMPLETED
Gout; Hyperuricemia; Arthritis; Joint Disease
BioCryst Pharmaceuticals
 2010-12 PHASE2
NCT01407874 COMPLETED
Gout; Hyperuricemia; Arthritis; Joint Disease; Renal Insufficiency
BioCryst Pharmaceuticals
 2011-09 PHASE2
NCT01147705 COMPLETED
Peripheral Arterial Disease
University of Dundee
 2011-02 PHASE4
NCT01265264 COMPLETED
Gout; Hyperuricemia; Arthritis; Joint Disease
BioCryst Pharmaceuticals
 2010-12 PHASE2
NCT01147705 COMPLETED
Peripheral Arterial Disease
University of Dundee
 2011-02 PHASE4
NCT01407874 COMPLETED
Gout; Hyperuricemia; Arthritis; Joint Disease; Renal Insufficiency
BioCryst Pharmaceuticals
 2011-09 PHASE2
NCT01399008 COMPLETED
Gout
Gilead Sciences
 2011-06 PHASE2
NCT01736514 COMPLETED
Gout
Astellas Pharma Taiwan, Inc.
 2011-03 PHASE3
NCT01399008 COMPLETED
Gout
Gilead Sciences
 2011-06 PHASE2
NCT01736514 COMPLETED
Gout
Astellas Pharma Taiwan, Inc.
 2011-03 PHASE3
NCT00732251 TERMINATED
Bipolar Disorder; Mania; Mixed Mania
Cedars-Sinai Medical Center
 2008-08 PHASE4
NCT00732251 TERMINATED
Bipolar Disorder; Mania; Mixed Mania
Cedars-Sinai Medical Center
 2008-08 PHASE4
NCT00189007 UNKNOWN
Fetal Hypoxia; Reperfusion Injury
UMC Utrecht
 2009-10 PHASE3
NCT00189007 UNKNOWN
Fetal Hypoxia; Reperfusion Injury
UMC Utrecht
 2009-10 PHASE3
NCT01077284 COMPLETED
Hyperuricosuria; Kidney Stones
Takeda
 2010-02 PHASE2
NCT01077284 COMPLETED
Hyperuricosuria; Kidney Stones
Takeda
 2010-02 PHASE2
NCT01701622 TERMINATED
Blood Pressure; Gout
University of Mississippi Medical Center
 2010-01
NCT01701622 TERMINATED
Blood Pressure; Gout
University of Mississippi Medical Center
 2010-01
NCT00849368 COMPLETED
Inflammatory Bowel Disease
University of Zurich
 2009-01 PHASE1
NCT00849368 COMPLETED
Inflammatory Bowel Disease
University of Zurich
 2009-01 PHASE1
NCT00241839 COMPLETED
Cardiovascular Diseases; Heart Diseases; Hypertension
University of Florida
 2005-08 PHASE3
NCT00241839 COMPLETED
Cardiovascular Diseases; Heart Diseases; Hypertension
University of Florida
 2005-08 PHASE3
NCT01092221 COMPLETED
Mania
Sheba Medical Center
 2010-05 PHASE3
NCT01092221 COMPLETED
Mania
Sheba Medical Center
 2010-05 PHASE3
NCT01157936 COMPLETED
Systolic and Diastolic Blood Pressure Levels; Uric Acid Levels; Metabolic Syndrome Parameters; Hepatic Enzymes
Instituto Nacional de Cardiologia Ignacio Chavez
 2010-07 PHASE2
NCT01157936 COMPLETED
Systolic and Diastolic Blood Pressure Levels; Uric Acid Levels; Metabolic Syndrome Parameters; Hepatic Enzymes
Instituto Nacional de Cardiologia Ignacio Chavez
 2010-07 PHASE2
NCT01001338 COMPLETED
Gout
Ardea Biosciences, Inc.
 2009-10 PHASE2
NCT00401388 COMPLETED
Chondrosarcomas; Alveolar Soft Part Sarcomas; Extra Skeletal Myxoid Chondrosarcomas
AEterna Zentaris
 2006-11 PHASE2
NCT01001338 COMPLETED
Gout
Ardea Biosciences, Inc.
 2009-10 PHASE2
NCT00288158 COMPLETED
Obesity; Pre-Hypertension; Hyperuricemia
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 2008-09 PHASE2
NCT00401388 COMPLETED
Chondrosarcomas; Alveolar Soft Part Sarcomas; Extra Skeletal Myxoid Chondrosarcomas
AEterna Zentaris
 2006-11 PHASE2
NCT00288158 COMPLETED
Obesity; Pre-Hypertension; Hyperuricemia
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 2008-09 PHASE2
NCT01109121 COMPLETED
Moderate to Severe Gout; Hyperuricemia
Nuon Therapeutics, Inc.
 2010-06 PHASE2
NCT00181155 COMPLETED
Congestive Heart Failure
Johns Hopkins University
 2004-11 PHASE2
NCT00958438 COMPLETED
Gout
Regeneron Pharmaceuticals
 2009-07 PHASE3
NCT01109121 COMPLETED
Moderate to Severe Gout; Hyperuricemia
Nuon Therapeutics, Inc.
 2010-06 PHASE2
NCT00181155 COMPLETED
Congestive Heart Failure
Johns Hopkins University
 2004-11 PHASE2
NCT00958438 COMPLETED
Gout
Regeneron Pharmaceuticals
 2009-07 PHASE3
NCT01052272 COMPLETED
Diabetes
University of Alabama at Birmingham
 2005-07 PHASE2; PHASE3
NCT00109837 COMPLETED
Leukemia
SWOG Cancer Research Network
 2005-04 PHASE2
NCT01129648 COMPLETED
Gout
BioCryst Pharmaceuticals
 2010-05 PHASE2
NCT01052272 COMPLETED
Diabetes
University of Alabama at Birmingham
 2005-07 PHASE2; PHASE3
NCT00109837 COMPLETED
Leukemia
SWOG Cancer Research Network
 2005-04 PHASE2
NCT01129648 COMPLETED
Gout
BioCryst Pharmaceuticals
 2010-05 PHASE2
NCT01188005 UNKNOWN
Obstructive Sleep Apnea Syndrome
University of Athens
 2010-08
NCT01188005 UNKNOWN
Obstructive Sleep Apnea Syndrome
University of Athens
 2010-08
NCT00039130 COMPLETED
Leukemia; Lymphoma
Alliance for Clinical Trials in Oncology
 2002-05 PHASE2
NCT00039130 COMPLETED
Leukemia; Lymphoma
Alliance for Clinical Trials in Oncology
 2002-05 PHASE2
NCT00819585 COMPLETED
Gout
Novartis Pharmaceuticals
 2008-12 PHASE2
NCT00819585 COMPLETED
Gout
Novartis Pharmaceuticals
 2008-12 PHASE2
NCT00919243 COMPLETED
Heart Failure; Hyperuricemia
Hebei Medical University
 2009-02 PHASE4
NCT00919243 COMPLETED
Heart Failure; Hyperuricemia
Hebei Medical University
 2009-02 PHASE4
NCT01052987 COMPLETED
Gout; Hyperuricemia
Nuon Therapeutics, Inc.
 2010-01 PHASE2
NCT00643123 COMPLETED
Bipolar Disorder; Mixed Mania; Treatment-Resistant Mania
Cedars-Sinai Medical Center
 2007-09 PHASE4
NCT00512057 COMPLETED
Syndrome X
University of Dundee
 2008-06 PHASE4
NCT01052987 COMPLETED
Gout; Hyperuricemia
Nuon Therapeutics, Inc.
 2010-01 PHASE2
NCT00643123 COMPLETED
Bipolar Disorder; Mixed Mania; Treatment-Resistant Mania
Cedars-Sinai Medical Center
 2007-09 PHASE4
NCT00512057 COMPLETED
Syndrome X
University of Dundee
 2008-06 PHASE4
NCT00829829 COMPLETED
Intercritical Gout
Regeneron Pharmaceuticals
 2009-02 PHASE3
NCT00829829 COMPLETED
Intercritical Gout
Regeneron Pharmaceuticals
 2009-02 PHASE3
NCT00864825 COMPLETED
Schizophrenia; Schizoaffective Disorder
Sheba Medical Center
 2009-08 PHASE4
NCT00864825 COMPLETED
Schizophrenia; Schizoaffective Disorder
Sheba Medical Center
 2009-08 PHASE4
NCT00652899 TERMINATED
Fallopian Tube Cancer; Ovarian Cancer; Peritoneal Cavity Cancer
Masonic Cancer Center, University of Minnesota
 2008-03 PHASE2
NCT00688480 COMPLETED
Kidney Disease; Left Ventricular Hypertrophy
A. D. Struthers
 2008-01 PHASE4
NCT00652899 TERMINATED
Fallopian Tube Cancer; Ovarian Cancer; Peritoneal Cavity Cancer
Masonic Cancer Center, University of Minnesota
 2008-03 PHASE2
NCT00688480 COMPLETED
Kidney Disease; Left Ventricular Hypertrophy
A. D. Struthers
 2008-01 PHASE4
NCT01310673 COMPLETED
Gout; Gout Acute
White River Junction Veterans Affairs Medical Center
 1998-01 PHASE4
NCT01310673 COMPLETED
Gout; Gout Acute
White River Junction Veterans Affairs Medical Center
 1998-01 PHASE4
NCT00793585 COMPLETED
IgA Nephropathy
Sun Yat-sen University
 2007-07
NCT00793585 COMPLETED
IgA Nephropathy
Sun Yat-sen University
 2007-07
NCT00978653 COMPLETED
Hyperuricemia; Chronic Kidney Disease
Istanbul University
 2008-04
NCT00978653 COMPLETED
Hyperuricemia; Chronic Kidney Disease
Istanbul University
 2008-04
NCT00607152 TERMINATED
Hyperuricemia
Sanofi
 2007-10 PHASE3
NCT00607152 TERMINATED
Hyperuricemia
Sanofi
 2007-10 PHASE3
NCT00610363 COMPLETED
Gout
Regeneron Pharmaceuticals
 2007-11 PHASE2
NCT00610363 COMPLETED
Gout
Regeneron Pharmaceuticals
 2007-11 PHASE2
NCT00823199 COMPLETED
Schizophrenia
Bronx Psychiatric Center
 2005-11
NCT00639756 COMPLETED
Metabolic Syndrome
Hospital Mateo Orfila
 2008-06 PHASE2
NCT00823199 COMPLETED
Schizophrenia
Bronx Psychiatric Center
 2005-11
NCT00639756 COMPLETED
Metabolic Syndrome
Hospital Mateo Orfila
 2008-06 PHASE2
NCT00480883 COMPLETED
Leishmaniasis, Cutaneous
Combined Military Hospital, Pakistan
 2008-01
NCT00480883 COMPLETED
Leishmaniasis, Cutaneous
Combined Military Hospital, Pakistan
 2008-01
NCT00199043 COMPLETED
Adult Acute Lymphocytic Leukemia; High-grade Lymphoma
Goethe University
 2003-05 PHASE3
NCT00199043 COMPLETED
Adult Acute Lymphocytic Leukemia; High-grade Lymphoma
Goethe University
 2003-05 PHASE3
NCT01603134 COMPLETED
Fasting State
IPCA Laboratories Ltd.
 2007-11 PHASE1
NCT01603134 COMPLETED
Fasting State
IPCA Laboratories Ltd.
 2007-11 PHASE1
NCT00430248 COMPLETED
Gout
Takeda
 2007-02 PHASE3
NCT00430248 COMPLETED
Gout
Takeda
 2007-02 PHASE3
NCT00288171 WITHDRAWN
Hypertension; Renal Transplant
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 2006-02 PHASE1; PHASE2
NCT00288171 WITHDRAWN
Hypertension; Renal Transplant
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 2006-02 PHASE1; PHASE2
NCT00230178 COMPLETED
Tumor Lysis Syndrome; Cancer; Hyperuricemia
Sanofi
 2004-04 PHASE3
NCT00061945 COMPLETED
Acute Undifferentiated Leukemia; B-cell Adult Acute Lymphoblastic Leukemia; B-cell Childhood Acute Lymphoblastic Leukemia; L1 Adult Acute Lymphoblastic Leukemia; L1 Childhood Acute Lymphoblastic Leukemia; L2 Adult Acute Lymphoblastic Leukemia; L2 Childhood Acute Lymphoblastic Leukemia; Philadelphia Chromosome Negative Adult Precursor Acute Lymphoblastic Leukemia; Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia; Philadelphia Chromosome Positive Childhood Precursor Acute Lymphoblastic Leukemia; T-cell Adult Acute Lymphoblastic Leukemia; T-cell Childhood Acute Lymphoblastic Leukemia; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Childhood Acute Lymphoblastic Leukemia
National Cancer Institute (NCI)
 2003-06 PHASE1; PHASE2
NCT00230178 COMPLETED
Tumor Lysis Syndrome; Cancer; Hyperuricemia
Sanofi
 2004-04 PHASE3
NCT00061945 COMPLETED
Acute Undifferentiated Leukemia; B-cell Adult Acute Lymphoblastic Leukemia; B-cell Childhood Acute Lymphoblastic Leukemia; L1 Adult Acute Lymphoblastic Leukemia; L1 Childhood Acute Lymphoblastic Leukemia; L2 Adult Acute Lymphoblastic Leukemia; L2 Childhood Acute Lymphoblastic Leukemia; Philadelphia Chromosome Negative Adult Precursor Acute Lymphoblastic Leukemia; Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia; Philadelphia Chromosome Positive Childhood Precursor Acute Lymphoblastic Leukemia; T-cell Adult Acute Lymphoblastic Leukemia; T-cell Childhood Acute Lymphoblastic Leukemia; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Childhood Acute Lymphoblastic Leukemia
National Cancer Institute (NCI)
 2003-06 PHASE1; PHASE2
NCT00821392 COMPLETED
Gout
SK Chemicals Co., Ltd.
 2006-08 PHASE3
NCT00821392 COMPLETED
Gout
SK Chemicals Co., Ltd.
 2006-08 PHASE3
NCT00288184 COMPLETED
Essential Hypertension
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 2004-09 PHASE2
NCT00288184 COMPLETED
Essential Hypertension
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 2004-09 PHASE2
NCT00175019 COMPLETED
Gout
Takeda
 2003-07 PHASE3
NCT00175019 COMPLETED
Gout
Takeda
 2003-07 PHASE3
NCT00053196 COMPLETED
Leukemia; Lymphoma; Multiple Myeloma; Plasma Cell Neoplasm; Myelodysplastic Syndromes; Myeloproliferative Neoplasms
Alliance for Clinical Trials in Oncology
 2002-12 PHASE2
NCT00053196 COMPLETED
Leukemia; Lymphoma; Multiple Myeloma; Plasma Cell Neoplasm; Myelodysplastic Syndromes; Myeloproliferative Neoplasms
Alliance for Clinical Trials in Oncology
 2002-12 PHASE2
NCT00276003 COMPLETED
Non-Hodgkin's Lymphoma; Cancer
University of New Mexico
 2002-08 PHASE2
NCT00276003 COMPLETED
Non-Hodgkin's Lymphoma; Cancer
University of New Mexico
 2002-08 PHASE2
NCT00560079 COMPLETED
Mania
Hospital Espirita de Porto Alegre
 2003-11 PHASE4
NCT00560079 COMPLETED
Mania
Hospital Espirita de Porto Alegre
 2003-11 PHASE4
NCT00174915 COMPLETED
Gout
Takeda
 2003-02 PHASE3
NCT00174915 COMPLETED
Gout
Takeda
 2003-02 PHASE3
NCT00003700 COMPLETED
Leukemia
Alliance for Clinical Trials in Oncology
 1999-01 PHASE2
NCT00102440 COMPLETED
Gout
Takeda
 2002-07 PHASE3
NCT00003700 COMPLETED
Leukemia
Alliance for Clinical Trials in Oncology
 1999-01 PHASE2
NCT00102440 COMPLETED
Gout
Takeda
 2002-07 PHASE3
NCT00004755 COMPLETED
Leishmaniasis
National Institute of Allergy and Infectious Diseases (NIAID)
 1995-09 PHASE2
NCT00000658 COMPLETED
Lymphoma, Non-Hodgkin; HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
 PHASE3
NCT00346463 UNKNOWN
Fetal Growth Retardation
UMC Utrecht
 2006-07
NCT00997542 COMPLETED
Chronic Heart Failure; Hyperuricemia
National Heart and Lung Institute
 PHASE4
NCT00000703 COMPLETED
Lymphoma, Non-Hodgkin; HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00477789 COMPLETED
Chronic Heart Failure
Universita di Verona
 PHASE4
NCT00214084 WITHDRAWN
Obstructive Sleep Apnea
University of Wisconsin, Madison
NCT00004755 COMPLETED
Leishmaniasis
National Institute of Allergy and Infectious Diseases (NIAID)
 1995-09 PHASE2
NCT00000658 COMPLETED
Lymphoma, Non-Hodgkin; HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
 PHASE3
NCT00346463 UNKNOWN
Fetal Growth Retardation
UMC Utrecht
 2006-07
NCT00000703 COMPLETED
Lymphoma, Non-Hodgkin; HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00997542 COMPLETED
Chronic Heart Failure; Hyperuricemia
National Heart and Lung Institute
 PHASE4
NCT00477789 COMPLETED
Chronic Heart Failure
Universita di Verona
 PHASE4
NCT00214084 WITHDRAWN
Obstructive Sleep Apnea
University of Wisconsin, Madison

(data from https://clinicaltrials.gov, updated on 2025-09-25)

Check the Allopurinol product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Allopurinol acts as a purine analog that binds and inhibits the enzyme xanthine oxidase, thereby blocking the successive oxidation of hypoxanthine and xanthine into uric acid. By suppressing uric acid biosynthesis and reducing systemic urate levels, this inhibition prevents crystal deposition and oxidative stress, directly supporting its clinical evaluation in gout, acute kidney injury, and vascular disorders.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.