CAS No. 138112-76-2

Batch: Purity:99.89
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Agomelatine (S20098) Chemical Structure
Chemical Structure
Check the Agomelatine (S20098) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide
CAS Number 138112-76-2
Molecular Formula

C15H17NO2
Molecular Weight (MW) 243.3
SMILES CC(=O)NCCC1=CC=CC2=C1C=C(C=C2)OC
InChIKey YJYPHIXNFHFHND-UHFFFAOYSA-N

Ordering Information

Biological Activity

Agomelatine (S20098) is a potent melatonin receptor agonist and 5-HT2C receptor antagonist, functioning as a norepinephrine-dopamine disinhibitor. By selectively antagonizing 5-HT2C receptors, agomelatine disinhibits and enhances norepinephrine and dopamine release in the frontal cortex. Simultaneously, activation of MT1 and MT2 melatonergic receptors resynchronizes circadian rhythms and promotes neurogenesis and neuroplasticity in the hippocampus, modulating downstream frontocortical dopaminergic and adrenergic pathways to exert its neurobiological functions. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 48 mg/mL (197.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 48 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.