CAS No. 142340-99-6

Batch: Purity:99.99
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Adefovir Dipivoxil (GS 0840) Chemical Structure
Chemical Structure
Check the Adefovir Dipivoxil (GS 0840) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [2-(6-aminopurin-9-yl)ethoxymethyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate
CAS Number 142340-99-6
Molecular Formula

C20H32N5O8P
Molecular Weight (MW) 501.47
SMILES CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C(N=CN=C21)N)OCOC(=O)C(C)(C)C
InChIKey WOZSCQDILHKSGG-UHFFFAOYSA-N

Biological Activity

Adefovir Dipivoxil (GS 0840) is a nucleotide analog prodrug that acts as a potent inhibitor of hepatitis B virus reverse transcriptase. Intracellularly converted to adefovir diphosphate, it competitively inhibits viral DNA polymerase and integrates into viral DNA to induce DNA chain termination. This inhibition blocks viral reverse transcription, suppressing hepatitis B virus genomic replication and viral DNA accumulation in host cells.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (199.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.