CAS No. 844442-38-2
Batch:
Purity:99.99
Chemical Structure
Check the
AT7519
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[(2,6-dichlorobenzoyl)amino]-N-piperidin-4-yl-1H-pyrazole-5-carboxamide | |
|---|---|---|
| CAS Number | 844442-38-2 | |
| Molecular Formula |
C16H17Cl2N5O2 |
|
| Molecular Weight (MW) | 382.24 | |
| SMILES | C1CNCCC1NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl | |
| InChIKey | OVPNQJVDAFNBDN-UHFFFAOYSA-N |
AT7519 is a multi-cyclin-dependent kinase (CDK) inhibitor targeting CDK1, CDK2, CDK4, CDK5, CDK6, and CDK9 with IC50 values ranging from 10 to. Inhibition of CDKs disrupts cell cycle progression and transcription, leading to reduced RNA polymerase II phosphorylation and downregulation of the anti-apoptotic protein Mcl-1. This targeted pathway inhibition results in cell cycle arrest and the induction of apoptosis in tumor cells. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
10 mg/mL
(26.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
25 mg/mL
(65.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.