CAS No. 328543-09-5
| IUPAC Name | 2-[4-[(dimethylamino)methyl]phenyl]-1,3,10-triazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-9-one | |
|---|---|---|
| CAS Number | 328543-09-5 | |
| Molecular Formula |
C19H20N4O |
|
| Molecular Weight (MW) | 320.39 | |
| SMILES | CN(C)CC1=CC=C(C=C1)C2=NC3=CC=CC4=C3N2CCNC4=O | |
| InChIKey | SEKJSSBJKFLZIT-UHFFFAOYSA-N |
AG-14361 is a potent poly(ADP-ribose) polymerase-1 (PARP1) inhibitor with a Ki of <5 nM. By blocking PARP1 catalytic activity, AG-14361 impairs DNA repair mechanisms, leading to increased DNA double-strand breaks and enhanced genomic instability. This inhibition selectively sensitizes cancer cells to DNA-damaging agents, potentiating the cytotoxic effects of topotecan, temozolomide, and ionizing radiation without altering topoisomerase I cellular activity. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
51 mg/mL
(159.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 21 mg/mL |
| Water | Insoluble |
| DMSO |
12 mg/mL
(37.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
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- Mix rapidly (pipette/vortex) upon addition.
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- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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