CAS No. 459868-92-9
Batch:
Purity:99.88
Chemical Structure
Check the
Rucaparib phosphate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-fluoro-2-[4-(methylaminomethyl)phenyl]-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-9-one;phosphoric acid | |
|---|---|---|
| CAS Number | 459868-92-9 | |
| Molecular Formula |
C19H18FN3O.H3PO4 |
|
| Molecular Weight (MW) | 421.36 | |
| SMILES | CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=C3C(=CC(=C4)F)N2.OP(=O)(O)O | |
| InChIKey | FCCGJTKEKXUBFZ-UHFFFAOYSA-N |
Rucaparib phosphate is a poly(ADP-ribose) polymerase inhibitor targeting PARP1 with a Ki of. By inhibiting PARP1, it disrupts single-strand DNA break repair through the base excision repair pathway. Unrepaired DNA damage accumulates, leading to synthetic lethality and apoptosis in BRCA1/2-deficient cancer cells, while significantly potentiating the cytotoxic effects of alkylating agents such as temozolomide. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
84 mg/mL
(199.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
84 mg/mL
(199.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
84 mg/mL
(199.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 2 mg/mL |
| Ethanol | Insoluble |
| DMSO |
84 mg/mL
(199.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 6 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Rucaparib phosphate Clinical Trials
- Rucaparib phosphate Solubility in DMSO
- Rucaparib phosphate Stock Solution
- Rucaparib phosphate Storage
- Rucaparib phosphate Stability
- Rucaparib phosphate Molecular Weight
- Rucaparib phosphate SMILES
- Rucaparib phosphate Chemical Structure (2D and 3D)
- Rucaparib phosphate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.