CAS No. 934162-61-5

Batch: Purity:99.98
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A-966492 Chemical Structure
Chemical Structure
Check the A-966492 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[2-fluoro-4-[(2S)-pyrrolidin-2-yl]phenyl]-1H-benzimidazole-4-carboxamide
CAS Number 934162-61-5
Molecular Formula

C18H17FN4O
Molecular Weight (MW) 324.35
SMILES C1CC(NC1)C2=CC(=C(C=C2)C3=NC4=C(C=CC=C4N3)C(=O)N)F
InChIKey AHIVQGOUBLVTCB-AWEZNQCLSA-N

Ordering Information

Biological Activity

A-966492 is a potent inhibitor of PARP1 and PARP2. By suppressing poly(ADP-ribosyl)ation, it impairs the repair of DNA single-strand breaks, leading to the accumulation of DNA double-strand breaks and promotion of synthetic lethality in cancer cells. Furthermore, A-966492 exhibits oral bioavailability and robust antitumor efficacy in vivo both as a single agent and in combination with chemotherapeutic agents. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 33 mg/mL (101.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.