CAS No. 164178-33-0

Batch: Purity:99.87
Check CoA
6-Iodopravadoline (AM630) Chemical Structure
Chemical Structure
Check the 6-Iodopravadoline (AM630) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [6-iodo-2-methyl-1-(2-morpholin-4-ylethyl)indol-3-yl]-(4-methoxyphenyl)methanone
CAS Number 164178-33-0
Molecular Formula

C23H25IN2O3
Molecular Weight (MW) 504.36
SMILES COC1=CC=C(C=C1)C(=O)C2=C(C)[N](CCN3CCOCC3)C4=C2C=CC(=C4)I
InChIKey JHOTYHDSLIUKCJ-UHFFFAOYSA-N

Ordering Information

Biological Activity

6-Iodopravadoline (AM630) is a selective cannabinoid CB2 receptor antagonist and inverse agonist with a Ki of. By selectively binding and inactivating CB2 receptors, AM630 blocks downstream signaling pathways and counteracts agonist-induced responses. This functional inhibition modulates immune cell activity, alters cytokine production, and impacts inflammatory phenotypic outcomes across multiple biological systems. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 50 mg/mL (99.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.