CAS No. 6665-83-4
Batch:
Purity:99.96
Chemical Structure
Check the
6-Hydroxyflavone (6-HF)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 6665-83-4 | |
|---|---|---|
| Molecular Formula |
C15H10O3 |
|
| Molecular Weight (MW) | 238.24 | |
| SMILES | C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=CC(=C3)O |
6-Hydroxyflavone is a naturally occurring flavonoid that acts as a partial agonist at GABAA receptors. By selectively binding to the benzodiazepine site on GABAA receptor complexes, it modulates GABA-mediated inhibitory neurotransmission in the central nervous system. Downstream, this pathway activation promotes anxiolytic-like behavioral phenotypes in animal models, demonstrating anxiolytic properties without inducing marked sedation or motor deficits.
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
47 mg/mL
(197.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- 6-Hydroxyflavone (6-HF) Solubility in DMSO
- 6-Hydroxyflavone (6-HF) Stock Solution
- 6-Hydroxyflavone (6-HF) Storage
- 6-Hydroxyflavone (6-HF) Stability
- 6-Hydroxyflavone (6-HF) Molecular Weight
- 6-Hydroxyflavone (6-HF) SMILES
- 6-Hydroxyflavone (6-HF) Chemical Structure (2D and 3D)
- 6-Hydroxyflavone (6-HF) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.