CAS No. 329-89-5

Batch: Purity:99.82
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6AN (6-Aminonicotinamide) Chemical Structure
Chemical Structure
Check the 6AN (6-Aminonicotinamide) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6-aminopyridine-3-carboxamide
CAS Number 329-89-5
Molecular Formula

C6H7N3O
Molecular Weight (MW) 137.14
SMILES NC(=O)C1=CC=C(N)N=C1
InChIKey ZLWYEPMDOUQDBW-UHFFFAOYSA-N

Ordering Information

Biological Activity

6AN (6-Aminonicotinamide) is a nicotinamide analogue antimetabolite and competitive inhibitor of glucose-6-phosphate dehydrogenase (G6PD). By blocking G6PD, 6AN inhibits the NADPH-producing pentose phosphate pathway (PPP). This pathway disruption leads to decreased intracellular NADPH levels, impairment of antioxidant defense mechanisms, accumulation of reactive oxygen species (ROS), and increased susceptibility of cells to oxidative stress and apoptosis. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 27 mg/mL (196.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.