Clinical Trials

5-Fluorouracil has undergone extensive investigation across numerous clinical trials, encompassing Phase 1 through Phase 4 evaluations alongside observational studies. These studies primarily focus on gastrointestinal malignancies—including colorectal, pancreatic, gastric, and esophageal cancers—as well as indications such as germ cell tumors and cervical intraepithelial neoplasia in HIV-positive patients. Sponsored by government entities, university medical centers, and pharmaceutical groups, these trials encompass various statuses, including recruiting, active not recruiting, and completed.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06831981 RECRUITING
Rectal Cancer
University Hospital Tuebingen
 2024-09-11
NCT06780111 RECRUITING
Esophageal Squamous Cell Carcinoma
Merck Sharp & Dohme LLC
 2025-07-30 PHASE1; PHASE2
NCT07585279 NOT_YET_RECRUITING
Metastatic Colorectal Cancer (CRC); Liposomal Irinotecan; Second-Line
Hebei Medical University Fourth Hospital
 2026-05-20 PHASE2; PHASE3
NCT06988852 RECRUITING
Colorectal Liver Metastasis (CRLM)
Tongji Hospital
 2023-05-01 PHASE2
NCT07662031 NOT_YET_RECRUITING
Colorectal Cancer; Metastatic Colorectal Cancer
Washington University School of Medicine
 2026-08-31 PHASE2
NCT04495088 RECRUITING
Rectal Cancer
Ralf Hofheinz
 2020-09-30 PHASE3
NCT07183865 RECRUITING
Locally Recurrent Rectal Cancer
Fudan University
 2025-03-09 PHASE2
NCT07730021 NOT_YET_RECRUITING
Locally Advanced or Metastatic Solid Tumors
Astellas Pharma Global Development, Inc.
 2026-08-31 PHASE1; PHASE2
NCT05067283 RECRUITING
Advanced Solid Tumors
Merck Sharp & Dohme LLC
 2021-12-17 PHASE1
NCT07283367 RECRUITING
CRC
Hansoh BioMedical R&D Company
 2025-12-22 PHASE1; PHASE2
NCT06609551 RECRUITING
Colon Cancer; Colon Cancer (Stage II &Amp;Amp;Amp; III)
Zhejiang Cancer Hospital
 2024-07-03 PHASE3
NCT07251062 NOT_YET_RECRUITING
Esophageal Squamous Cell Carcinoma
CSPC Megalith Biopharmaceutical Co.,Ltd.
 2025-12-30 PHASE2; PHASE3
NCT06428409 RECRUITING
Colorectal Cancer; Pancreatic Ductal Adenocarcinoma; Biliary Tract Cancer
Merck Sharp & Dohme LLC
 2024-06-20 PHASE1; PHASE2
NCT07028424 NOT_YET_RECRUITING
PDAC - Pancreatic Ductal Adenocarcinoma
GERCOR - Multidisciplinary Oncology Cooperative Group
 2025-07 PHASE2
NCT07276399 RECRUITING
Squamous Cell Carcinoma of Head and Neck
Janssen Research & Development, LLC
 2025-12-03 PHASE3
NCT07621497 NOT_YET_RECRUITING
Metastatic Colorectal Cancer (CRC)
Sun Yat-sen University
 2026-06-01 PHASE2
NCT06586515 RECRUITING
Pancreatic Ductal Adenocarcinoma; Non-small Cell Lung Cancer; Colorectal Cancer
Eli Lilly and Company
 2024-09-12 PHASE1
NCT04642287 WITHDRAWN
Immunotherapy; Cutaneous Squamous Cell Carcinoma; Actinic Keratoses; Organ Transplant Recipients; Skin Cancer
Massachusetts General Hospital
 2026-01 PHASE2
NCT07790445 NOT_YET_RECRUITING
Malignant Biliary Tract Tumors
Zhai Wenlong
 2026-07-30 PHASE4
NCT07700667 RECRUITING
Esophageal Squamous Cell Carcinoma
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.
 2026-08-13 PHASE2
NCT07391566 NOT_YET_RECRUITING
Metastatic Colorectal Cancer (mCRC)
Luye Pharma Group Ltd.
 2026-03-31 PHASE1; PHASE2
NCT06662786 RECRUITING
Colorectal Neoplasms
Janssen Research & Development, LLC
 2024-10-18 PHASE3
NCT06887218 RECRUITING
Metastatic Colorectal Cancer (CRC)
The Methodist Hospital Research Institute
 2025-05-08 PHASE2
NCT06535607 RECRUITING
Sub-study 1 Cervical Cancer (Volrustomig Monotherapy); Sub-study 2 Head and Neck Squamous Cell Carcinoma (Volrustomig Monotherapy); Sub-study 3 Head and Neck Squamous Cell Carcinoma (Volrustomig in Combination With Chemotherapy); Sub-study 4 Esophageal Squamous Cell Carcinoma (Volrustomig in Combination With Chemotherapy); Sub-study 5 Unresectable Pleural Mesothelioma (Volrustomig Monotherapy)
AstraZeneca
 2024-08-22 PHASE2
NCT07238283 RECRUITING
First-line Treatment of Metastatic Pancreatic Cancer
Jiangsu HengRui Medicine Co., Ltd.
 2025-12-02 PHASE3
NCT06699212 RECRUITING
Recurrent Head and Neck Squamous Cell Carcinoma
Rakuten Medical, Inc.
 2024-12-24 PHASE3
NCT02885753 RECRUITING
Colorectal Neoplasms
Federation Francophone de Cancerologie Digestive
 2016-12 PHASE3
NCT06733038 RECRUITING
Colorectal Cancer
Gruppo Oncologico del Nord-Ovest
 2024-11-15 PHASE3
NCT06109467 ACTIVE_NOT_RECRUITING
GastroEsophageal Cancer; Gastric Cancer
H. Lee Moffitt Cancer Center and Research Institute
 2024-01-12 PHASE2
NCT04901741 NOT_YET_RECRUITING
Metastatic Pancreatic Cancer
TME Pharma AG
 2026-01 PHASE2
NCT07094893 NOT_YET_RECRUITING
Colorectal Cancer
Gruppo Oncologico del Nord-Ovest
 2026-09-15 PHASE4
NCT04380545 RECRUITING
Stage III Hepatocellular Carcinoma AJCC v8; Stage IIIA Hepatocellular Carcinoma AJCC v8; Stage IIIB Hepatocellular Carcinoma AJCC v8; Stage IV Hepatocellular Carcinoma AJCC v8; Stage IVA Hepatocellular Carcinoma AJCC v8; Stage IVB Hepatocellular Carcinoma AJCC v8; Unresectable Fibrolamellar Carcinoma
M.D. Anderson Cancer Center
 2021-01-13 PHASE1; PHASE2
NCT07733180 NOT_YET_RECRUITING
Advanced Esophageal Squamous Cell Carcinoma; Metastatic Esophageal Squamous Cell Carcinoma
BeOne Medicines
 2026-08-31 PHASE2
NCT06757244 RECRUITING
Pancreas Neoplasms
Hopital Foch
 2025-02-18 PHASE2
NCT05733000 RECRUITING
Advanced Biliary Tract Carcinoma; Advanced Colorectal Carcinoma; Advanced Gastroesophageal Junction Adenocarcinoma; Advanced Lung Adenocarcinoma; Advanced Malignant Solid Neoplasm; Advanced Ovarian Carcinoma; Advanced Pancreatic Carcinoma; Advanced Urothelial Carcinoma; Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8; Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8; Metastatic Biliary Tract Carcinoma; Metastatic Colorectal Carcinoma; Metastatic Gastroesophageal Junction Adenocarcinoma; Metastatic Lung Adenocarcinoma; Metastatic Ovarian Carcinoma; Metastatic Pancreatic Carcinoma; Metastatic Urothelial Carcinoma; Refractory Biliary Tract Carcinoma; Refractory Colorectal Carcinoma; Refractory Gastroesophageal Junction Adenocarcinoma; Refractory Lung Adenocarcinoma; Refractory Ovarian Carcinoma; Refractory Pancreatic Carcinoma; Refractory Urothelial Carcinoma; Stage II Pancreatic Cancer AJCC v8; Stage III Colorectal Cancer AJCC v8; Stage III Lung Cancer AJCC v8; Stage III Ovarian Cancer AJCC v8; Stage III Pancreatic Cancer AJCC v8; Stage IV Colorectal Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IV Ovarian Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8
Northwestern University
 2023-03-08 PHASE2
NCT06771622 ACTIVE_NOT_RECRUITING
Solid Cancer
FBD Biologics Limited
 2025-03-13 PHASE1; PHASE2
NCT07314385 NOT_YET_RECRUITING
Pancreatic Adenocarcinoma Metastatic; Liver Metastasis
National Taiwan University Hospital
 2026-01-01 PHASE1
NCT06731803 ACTIVE_NOT_RECRUITING
Esophagogastric Adenocarcinoma
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
 2025-03-25 PHASE1; PHASE2
NCT06750094 RECRUITING
Colorectal Neoplasms
Janssen Research & Development, LLC
 2024-12-12 PHASE3
NCT03073785 ACTIVE_NOT_RECRUITING
Pancreatic Adenocarcinoma; Recurrent Pancreatic Carcinoma; Stage I Pancreatic Cancer AJCC v6 and v7; Stage IA Pancreatic Cancer AJCC v6 and v7; Stage IB Pancreatic Cancer AJCC v6 and v7; Stage II Pancreatic Cancer AJCC v6 and v7; Stage IIA Pancreatic Cancer AJCC v6 and v7; Stage IIB Pancreatic Cancer AJCC v6 and v7; Stage III Pancreatic Cancer AJCC v6 and v7; Stage IV Pancreatic Cancer AJCC v6 and v7
University of Nebraska
 2016-09-16 PHASE2
NCT05671822 RECRUITING
HER2 Expression Gastric Cancer/Gastroesophageal Junction Adenocarcinoma
Suzhou Suncadia Biopharmaceuticals Co., Ltd.
 2023-03-14 PHASE2
NCT04150640 RECRUITING
Esophageal Adenocarcinoma; Gastric Adenocarcinoma
University of Wisconsin, Madison
 2020-07-13 PHASE2
NCT05702229 RECRUITING
Gastric Cancer
AstraZeneca
 2023-01-16 PHASE2
NCT05062889 SUSPENDED
Stage II Colon Cancer; Stage III Colon Cancer; HER2-positive Colon Cancer; RAS Wild-type Colon Cancer
Gruppo Oncologico del Nord-Ovest
 2023-05-17 PHASE2
NCT07474727 RECRUITING
Colorectal Cancer
Multitude Therapeutics Inc.
 2026-04-29 PHASE2
NCT06766019 ACTIVE_NOT_RECRUITING
Pancreatic Cancer
The First Affiliated Hospital with Nanjing Medical University
 2024-10-16 PHASE2
NCT07337421 RECRUITING
Hepatocellular Carcinoma (HCC)
Northern Jiangsu People's Hospital
 2025-09-01 PHASE2
NCT07353827 NOT_YET_RECRUITING
Intrahepatic Cholangiocarcinoma (Icc); Hepatic Arterial Infusion Chemotherapy
Sun Yat-sen University
 2026-02-01 PHASE2
NCT06057038 ACTIVE_NOT_RECRUITING
Malignant Solid Tumor
Genmab
 2023-11-24 PHASE1
NCT07363408 NOT_YET_RECRUITING
Advanced Microsatellite Stable Colorectal Carcinoma; Metastatic Microsatellite Stable Colorectal Carcinoma; Stage III Colorectal Cancer AJCC v8; Stage IV Colorectal Cancer AJCC v8
City of Hope Medical Center
 2026-12-01 PHASE1
NCT03977233 RECRUITING
Pancreatic Ductal Adenocarcinoma (PDAC); Cancer of Pancreas; Pancreatic Cancer, Adult; Pancreas Adenocarcinoma; Pancreatic Neoplasms; Pancreatic Cancer Non-resectable; Pancreatic Cancer Resectable
UNC Lineberger Comprehensive Cancer Center
 2019-06-12 PHASE2
NCT06576037 RECRUITING
Solid Tumor
M.D. Anderson Cancer Center
 2024-10-31 PHASE1
NCT06494514 RECRUITING
Locally Advanced Pancreatic Cancer
Du Juan
 2024-04-01
NCT06648525 NOT_YET_RECRUITING
Intrahepatic Cholangiocarcinoma (Icc)
Harbin Medical University
 2024-10 PHASE2
NCT06383078 NOT_YET_RECRUITING
Efficacy and Safety
The First Affiliated Hospital with Nanjing Medical University
 2024-04-20 PHASE2
NCT05699603 ACTIVE_NOT_RECRUITING
Actinic Keratosis
University of Arizona
 2024-07-02 PHASE2
NCT07446465 NOT_YET_RECRUITING
Colorectal Cancer (Locally Advanced or Metastatic); Colorectal Cancer Microsatellite Stable (MSS)
Ye Xu
 2026-03-01 PHASE4
NCT04241185 ACTIVE_NOT_RECRUITING
Urinary Bladder Neoplasms
Merck Sharp & Dohme LLC
 2020-05-19 PHASE3
NCT05229497 ACTIVE_NOT_RECRUITING
Advanced Malignant Tumors
Akeso
 2022-05-04 PHASE1; PHASE2
NCT01924819 ACTIVE_NOT_RECRUITING
Gastric Cancer
Australasian Gastro-Intestinal Trials Group
 2009-09 PHASE2; PHASE3
NCT06730373 RECRUITING
HER2-positive Gastric Cancer; Metastatic Gastric Cancer; Unresectable Gastric Carcinoma
Qilu Hospital of Shandong University
 2024-10-17 PHASE2
NCT07025174 RECRUITING
Bile Duct Carcinoma; Gall Bladder Cancer; Biliary Tract Cancer; Cholangiocarcinoma
First Affiliated Hospital of Zhejiang University
 2025-06-01 PHASE2
NCT07014540 NOT_YET_RECRUITING
Neuroendocrine Carcinomas (NEC)
Beijing GoBroad Hospital
 2025-06-20 PHASE4
NCT04460352 RECRUITING
Esophageal Squamous Cell Carcinoma
Karolinska University Hospital
 2020-11-27 PHASE3
NCT06943820 RECRUITING
Non-small Cell Lung Cancer Stage IIIB/IV; Head and Neck Squamous Cell Carcinoma (HNSCC); Colorectal Adenocarcinoma; Advanced Solid Tumors
Akeso
 2025-05-21 PHASE1; PHASE2
NCT06219941 RECRUITING
Gastric Cancer; Gastroesophageal Junction Cancer; Biliary Tract Cancer; Pancreatic Ductal Adenocarcinoma
AstraZeneca
 2023-12-13 PHASE2
NCT06825624 RECRUITING
Metastatic Colorectal Cancer (CRC)
Hansoh BioMedical R&D Company
 2024-10-03 PHASE1
NCT06894797 RECRUITING
Locally Advanced Rectal Cancer
Peking University Cancer Hospital & Institute
 2025-04-01
NCT06269978 ACTIVE_NOT_RECRUITING
Metastatic Colorectal Carcinoma; Metastatic Malignant Neoplasm in the Peritoneum; Stage IV Colorectal Cancer AJCC v8
Arjun Mittra
 2024-12-31 PHASE1
NCT04246684 ACTIVE_NOT_RECRUITING
Rectal Cancer Stage III
Prof. Dr. med. Claus Rödel
 2020-11-05 PHASE3
NCT06364384 RECRUITING
Rectal Squamous Cell Carcinoma
Sixth Affiliated Hospital, Sun Yat-sen University
 2024-04-12 PHASE2
NCT07047560 RECRUITING
Colorectal Cancer (CRC)
Tianjin Medical University Cancer Institute and Hospital
 2024-09-01 PHASE2
NCT02535221 RECRUITING
Breast Cancer
Peking University
 2015-07-29 PHASE3
NCT04375605 COMPLETED
Gastroesophageal Junction Adenocarcinoma
Universitätsmedizin Mannheim
 2020-06-03 PHASE3
NCT06625320 ACTIVE_NOT_RECRUITING
Pancreatic Cancer; PDAC; PDAC - Pancreatic Ductal Adenocarcinoma
Revolution Medicines, Inc.
 2024-10-16 PHASE3
NCT06370754 NOT_YET_RECRUITING
Pancreatic Cancer
Fudan University
 2024-04-30 PHASE1; PHASE2
NCT05446467 RECRUITING
Head and Neck Squamous Cell Carcinoma
Zhejiang Provincial People's Hospital
 2022-09-01 PHASE2
NCT06184698 RECRUITING
Colorectal Cancer
Hebei Medical University Fourth Hospital
 2024-01-01 PHASE2
NCT06172036 NOT_YET_RECRUITING
Neoadjuvant Chemotherapy; Resectable Pancreatic Cancer
Zhejiang University
 2024-01-20 PHASE2
NCT05630183 COMPLETED
Metastatic Pancreatic Ductal Adenocarcinoma
Agenus Inc.
 2023-03-27 PHASE2
NCT03326947 RECRUITING
Neoplasm Neck
Shanghai Jiao Tong University School of Medicine
 2018-01-01 PHASE2
NCT06225622 UNKNOWN
Metastatic Colorectal Cancer
Shanghai Zhongshan Hospital
 2024-03-11 PHASE1
NCT06685588 NOT_YET_RECRUITING
Actinic Keratosis of Face and Scalp; Actinic Keratoses
St Vincent's University Hospital, Ireland
 2025-01
NCT05780294 NOT_YET_RECRUITING
Nasopharyngeal Carcinoma; Leucogen; Chemotherapy; Myelosuppression
Sun Yat-sen University
 2023-04-01 PHASE3
NCT06700603 NOT_YET_RECRUITING
Pancreatic Cancer
Rui-hua Xu, MD, PhD
 2024-11-20 PHASE2
NCT06713057 NOT_YET_RECRUITING
Locally Advanced Thyroid Gland Carcinoma; Thyroid Cancer
West China Hospital
 2024-12-01 PHASE2
NCT04861558 RECRUITING
Colorectal Cancer; Peritoneal Metastases
Uppsala University
 2021-05-01 PHASE3
NCT02710734 COMPLETED
Urothelial Carcinoma of the Bladder
Fox Chase Cancer Center
 2016-02-24 PHASE2
NCT03281369 TERMINATED
Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma or Esophageal Carcinoma
Hoffmann-La Roche
 2017-10-13 PHASE1; PHASE2
NCT06839378 COMPLETED
Pseudomyxoma Peritonei
Beijing Tsinghua Chang Gung Hospital
 2025-02-17
NCT05007106 COMPLETED
Uterine Cervical Neoplasms; Endometrial Neoplasms; Squamous Cell Carcinoma of Head and Neck; Gallbladder Neoplasms; Cholangiocarcinoma; Esophageal Neoplasms; Triple Negative Breast Neoplasms; Hepatocellular Carcinoma; Urinary Bladder Neoplasms; Ovarian Neoplasms; Stomach Neoplasms
Merck Sharp & Dohme LLC
 2021-09-16 PHASE2
NCT04356170 COMPLETED
Cancer of Head and Neck
Groupe Oncologie Radiotherapie Tete et Cou
 2021-02-04 PHASE2
NCT05413811 COMPLETED
Cervical Cancer; CIN2; CIN3; Human Immunodeficiency Virus; Human Papillomavirus
UNC Lineberger Comprehensive Cancer Center
 2023-03-22
NCT06096220 ENROLLING_BY_INVITATION
Odontogenic Keratocyst
University of Belgrade
 2023-06-10 PHASE4
NCT04894370 RECRUITING
Squamous Cell Anal Carcinoma; Metastatic Squamous Cell Carcinoma
Centre Hospitalier Universitaire de Besancon
 2022-06-09 PHASE2
NCT05859750 RECRUITING
Pancreatic Cancer
Akeso
 2023-05-25 PHASE2
NCT06225999 COMPLETED
Metastatic Adenocarcinoma of the Pancreas
Institut de Recherches Internationales Servier
 2024-04-25 PHASE2
NCT06210360 NOT_YET_RECRUITING
Pancreatic Cancer
Changhai Hospital
 2024-02-01 PHASE2
NCT06363552 UNKNOWN
Metastatic Colorectal Cancer
Tianshu Liu
 2024-05 PHASE2
NCT04447092 UNKNOWN
Pancreatic Cancer; Chemotherapy Effect
Seoul National University Hospital
 2020-07-01 PHASE2
NCT04371224 UNKNOWN
Pancreatic Cancer
Seoul National University Hospital
 2020-06-23 PHASE2
NCT07317583 COMPLETED
Colorectal Cancer
Istanbul University - Cerrahpasa
 2024-04-10
NCT05546853 COMPLETED
Pancreatic Ductal Adenocarcinoma
University Hospital, Grenoble
 2023-03-28 PHASE1
NCT05628038 RECRUITING
Recurrent Rectal Cancer
Fudan University
 2022-11-30 PHASE2
NCT02290145 RECRUITING
Mouth Neoplasms; Carcinoma, Squamous Cell
Shanghai Jiao Tong University School of Medicine
 2016-12 PHASE2
NCT01628211 UNKNOWN
Colorectal Cancer
National Cancer Institute, Naples
 2012-04 PHASE2
NCT05960955 RECRUITING
Resectable Gastric or Gastroesophageal Junction Adenocarcinoma
Akeso
 2023-11-13 PHASE2
NCT04859582 WITHDRAWN
Stomach Neoplasms
Merck Sharp & Dohme LLC
 2018-11-08 PHASE3
NCT06820229 COMPLETED
Keratocysts of the Jaw
Tanta University
 2022-10-02
NCT05125055 RECRUITING
Oral Squamous Cell Carcinoma; Neoadjvant Therapy; Anti-PD-1; Chemotherapy
Shanghai Jiao Tong University School of Medicine
 2021-10-01 PHASE2; PHASE3
NCT03107182 COMPLETED
HPV-Related Squamous Cell Carcinoma; HNSCC
University of Chicago
 2017-06-27 PHASE2
NCT04047862 COMPLETED
Locally Advanced and Metastatic Solid Tumors
BeiGene
 2019-08-15 PHASE1
NCT05433597 NOT_YET_RECRUITING
Nasopharyngeal Carcinoma; TNF; Chemo-radiotherapy
Sun Yat-sen University
 2022-07-01 PHASE2; PHASE3
NCT03486340 COMPLETED
Solid Carcinoma; 5-Fluorouracil Toxicity; Cardiotoxicity; Chemotherapeutic Toxicity; Acute Coronary Syndrome; Coronary Artery Calcification; Chest Pain
Vejle Hospital
 2018-04-11
NCT05251727 TERMINATED
Chemotherapy-induced Peripheral Neuropathy
Veloxis Pharmaceuticals
 2022-03-24 PHASE1
NCT05383352 COMPLETED
Metastatic Pancreatic Adenocarcinoma
Ipsen
 2022-05-30 PHASE1
NCT03719924 COMPLETED
Squamous Cell Carcinoma
Federation Francophone de Cancerologie Digestive
 2019-03-07 PHASE2
NCT06197438 UNKNOWN
Gastric Cancer
Fujian Cancer Hospital
 2024-01-01 PHASE2
NCT06361316 Recruiting
Pancreatic Cancer|Adjuvant Therapy
Kuirong Jiang|CSPC Ouyi Pharmaceutical Co. Ltd.|The First Affiliated Hospital with Nanjing Medical University
 2024-04-08 Not Applicable
NCT03615326 COMPLETED
Gastric Neoplasms; Gastroesophageal Junction Adenocarcinoma
Merck Sharp & Dohme LLC
 2018-10-05 PHASE3
NCT05839470 UNKNOWN
Colorectal Cancer
Fujian Cancer Hospital
 2023-11-19 PHASE2
NCT04882241 COMPLETED
Gastric Cancer; Gastroesophageal Junction Cancer
Merck Sharp & Dohme LLC
 2020-07-29 PHASE3
NCT03530267 COMPLETED
Colorectal Cancer
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
 2018-09-28 PHASE2
NCT03904381 UNKNOWN
Open-angle Glaucoma
Wroclaw Medical University
 2016-01-01 PHASE4
NCT04890522 NOT_YET_RECRUITING
Nasopharyngeal Carcinoma; Metastasis; Chemotherapy; Immunotherapy; Survival
Sun Yat-sen University
 2021-07-01 PHASE2; PHASE3
NCT05004350 COMPLETED
BRAF V600E; Metastatic Colorectal Cancer
Pierre Fabre Medicament
 2021-09-14 PHASE2
NCT04034459 UNKNOWN
Metastatic Colorectal Cancer
Ludwig-Maximilians - University of Munich
 2016-11-25 PHASE2
NCT04825288 COMPLETED
Pancreatic Cancer
XBiotech, Inc.
 2021-05-27 PHASE1; PHASE2
NCT03483038 ACTIVE_NOT_RECRUITING
Pancreatic Adenocarcinoma
University of Florida
 2018-12-13 PHASE2
NCT05257122 UNKNOWN
Advanced Pancreatic Carcinoma
Fudan University
 2022-02 PHASE2
NCT06782022 COMPLETED
Gastrointestinal Cancers
Jan Gerard Maring
 2020-02-02 PHASE2
NCT05780684 Recruiting
Colorectal Cancer|Esophagus Cancer|Appendix Cancer|Small Bowel Cancer|Ampullary Cancer
Dartmouth-Hitchcock Medical Center
 2023-07-14 Not Applicable
NCT04513951 COMPLETED
Metastatic Colorectal Cancer
Gruppo Oncologico del Nord-Ovest
 2020-04-01 PHASE2
NCT05362955 Active not recruiting
CIN 2/3|HIV Infections
UNC Lineberger Comprehensive Cancer Center
 2023-04-26 Phase 1
NCT05008887 UNKNOWN
Vitiligo
Assiut University
 2022-09 PHASE4
NCT03299660 COMPLETED
Rectal Cancer
Peter MacCallum Cancer Centre, Australia
 2018-04-30 PHASE2
NCT01991873 COMPLETED
Metastatic Colorectal Cancer
AIO-Studien-gGmbH
 2014-04 PHASE2
NCT04894123 TERMINATED
Colorectal Adenocarcinoma; Oesogastric
GERCOR - Multidisciplinary Oncology Cooperative Group
 2022-02-07 PHASE2
NCT04675983 TERMINATED
Gastric Adenocarcinoma
Innovent Biologics (Suzhou) Co. Ltd.
 2021-03-10 PHASE3
NCT03279289 COMPLETED
Metastatic Colorectal Cancer
Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
 2017-10-25 PHASE2
NCT03519295 COMPLETED
Anal Cancer
GERCOR - Multidisciplinary Oncology Cooperative Group
 2018-07-03 PHASE2
NCT05251038 WITHDRAWN
Pancreatic Cancer; Unresectable Pancreatic Cancer; Metastatic Pancreatic Cancer; KRAS P.G12C
Devalingam Mahalingam
 2022-09-13 PHASE1; PHASE2
NCT03712397 COMPLETED
Head & Neck Cancer
National Health Research Institutes, Taiwan
 2018-12-24 PHASE2
NCT03365765 COMPLETED
Apatinib
Huashan Hospital
 2018-02-12 PHASE3
NCT02919787 ACTIVE_NOT_RECRUITING
Pancreatic Cancer
Oslo University Hospital
 2016-09 PHASE2; PHASE3
NCT04926753 UNKNOWN
Locoregionally Advanced Laryngo-hypopharyngeal Squamous Cell Cancer
Ruijin Hospital
 2021-06-01 PHASE1
NCT05620524 Recruiting
TDM of 5-FU|Pharmacokinetic Observational Study
Catharina Ziekenhuis Eindhoven
 2022-12-19 --
NCT03750786 COMPLETED
Colo-rectal Cancer
Isofol Medical AB
 2018-12-18 PHASE3
NCT04747470 TERMINATED
Advanced Solid Tumors
Gilead Sciences
 2021-03-25 PHASE1
NCT05513924 COMPLETED
Vitiligo
South Valley University
 2022-03-15 PHASE2; PHASE3
NCT05505539 Withdrawn
Oral Leukoplakia
University of California San Francisco
 2022-09-30 Phase 1
NCT05520658 UNKNOWN
Plantar Wart
Sohag University
 2022-07-01
NCT04097444 UNKNOWN
Metastatic Colorectal Cancer
Chugai Pharmaceutical
 2019-10-11 PHASE2
NCT04710719 COMPLETED
Keloid; Keloid Scar Following Surgery
Our Lady of the Lake Hospital
 2021-02-01
NCT03992911 UNKNOWN
Neuroendocrine Carcinoma of the Bladder
Peking University
 2019-06-19 PHASE2; PHASE3
NCT04358341 UNKNOWN
Gastric Cancer
Sixth Affiliated Hospital, Sun Yat-sen University
 2020-06-17 PHASE2
NCT03206151 COMPLETED
Metastatic Colorectal Cancer
Taizhou Mabtech Pharmaceutical Co.,Ltd
 2017-12-12 PHASE3
NCT04886193 UNKNOWN
Chemotherapy; Gastric Cancer
Guangdong Provincial Hospital of Traditional Chinese Medicine
 2021-04-16
NCT05057663 UNKNOWN
Plantar Wart
Sohag University
 2021-11-01
NCT03387592 TERMINATED
Neuroendocrine Carcinoma
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
 2017-03-06 PHASE2
NCT02833753 COMPLETED
Colorectal Cancer; Appendix Cancer; Peritoneal Carcinomatosis
University of Massachusetts, Worcester
 2016-07 PHASE1
NCT02539537 COMPLETED
Pancreatic Cancer; Carcinoma
UNICANCER
 2015-10-23 PHASE3
NCT04875026 COMPLETED
Actinic Keratoses
Pierre Fabre Medicament
 2021-02-16 PHASE4
NCT04833036 UNKNOWN
Colorectal Cancer
Fudan University
 2019-10-01 PHASE2
NCT03788226 UNKNOWN
Gastric Cancer Stage III
Fujian Cancer Hospital
 2019-02-01 PHASE3
NCT02268695 COMPLETED
Head and Neck Squamous Cell Carcinoma
Groupe Oncologie Radiotherapie Tete et Cou
 2014-10-10 PHASE2
NCT03512756 TERMINATED
Pancreatic Cancer
Tyme, Inc
 2018-03-27 PHASE2; PHASE3
NCT03698461 COMPLETED
Colorectal Neoplasms; Neoplasm Metastasis; Colonic Neoplasms; Rectal Neoplasms
Asan Medical Center
 2019-05-15 PHASE2
NCT04121039 UNKNOWN
Gastric Adenocarcinoma; Advanced Cancer
Fujian Cancer Hospital
 2019-12 PHASE2
NCT03528785 UNKNOWN
Pancreatic Adenocarcinoma
Centro Ricerche Cliniche di Verona
 2018-03-02 PHASE2
NCT04834206 COMPLETED
Nasopharyngeal Carcinoma
Affiliated Cancer Hospital & Institute of Guangzhou Medical University
 2021-05-01 PHASE2
NCT04595929 RECRUITING
Peritoneal Carcinomatosis; Gastric Cancer
St. Petersburg State Pavlov Medical University
 2020-02-10
NCT04126655 UNKNOWN
Metastatic Colorectal Cancer
Vastra Gotaland Region
 2020-02-05 PHASE1; PHASE2
NCT01926197 COMPLETED
Pancreatic Cancer
Stanford University
 2013-08-14 PHASE3
NCT03703063 UNKNOWN
Pancreatic Adenocarcinoma
Benaroya Research Institute
 2018-09-17 PHASE1
NCT04430985 WITHDRAWN
Metastatic Colorectal Cancer
Dorte Nielsen
 2020-09-30 PHASE2
NCT02940925 COMPLETED
Nasopharyngeal Carcinoma
Sun Yat-sen University
 2016-10-20 PHASE3
NCT04812626 COMPLETED
Scar Keloid
B.P. Koirala Institute of Health Sciences
 2021-01-28
NCT02701088 COMPLETED
Locally Advanced Anal Canal Cancer
Centre Francois Baclesse
 2015-12 PHASE2
NCT04034173 TERMINATED
Treatment Related Cancer
Ludwig-Maximilians - University of Munich
 2019-07-24 PHASE2
NCT04370418 UNKNOWN
Neo-adjuvant Short Course Chemo-radiotherapy in Locally Advanced Cancer Rectum
Assiut University
 2020-05-01 PHASE2; PHASE3
NCT04170179 UNKNOWN
Hepatocellular Carcinoma
Sun Yat-sen University
 2019-11-19 PHASE2
NCT03722498 WITHDRAWN
Hepatocellular Carcinoma
Sun Yat-sen University
 2018-06-01 PHASE2
NCT00981656 COMPLETED
Bladder Cancer
Radiation Therapy Oncology Group
 2009-11 PHASE2
NCT03142516 COMPLETED
Colorectal Neoplasms; Colorectal Carcinoma; Colorectal Cancer Metastatic; Neoplasm Metastasis
Grupo Espanol Multidisciplinario del Cancer Digestivo
 2017-10-31 PHASE2
NCT03043729 COMPLETED
Rectal Cancer; Rectosigmoid Cancer
AIO-Studien-gGmbH
 2017-03-06 PHASE2
NCT04337879 UNKNOWN
Advanced Colorectal Cancer
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
 2020-07-20 PHASE1; PHASE2
NCT03855384 UNKNOWN
Squamous Cell Carcinoma of the Head and Neck
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
 2019-06-11 PHASE3
NCT03020329 UNKNOWN
Nasopharyngeal Carcinoma; Children
Sun Yat-sen University
 2016-11-14 PHASE2
NCT02870036 UNKNOWN
Advanced Solid Tumor; Advanced/Metastatic Colorectal Cancer
Haihe Biopharma Co., Ltd.
 2016-10 PHASE1
NCT04164238 UNKNOWN
Head and Neck Squamous Cell Carcinoma
First Affiliated Hospital of Zhejiang University
 2019-11-07 PHASE2
NCT03196180 COMPLETED
Cervical Intraepithelial Neoplasia Grade 2/3; Cervical Squamous Cell Carcinoma In Situ; Cervical Squamous Intraepithelial Neoplasia 2; High Grade Cervical Intraepithelial Neoplasia
National Cancer Institute (NCI)
 2019-10-15 EARLY_PHASE1
NCT03000374 COMPLETED
Rectal Cancer
Grupo Espanol Multidisciplinario del Cancer Digestivo
 2017-05-30 PHASE2
NCT03711240 UNKNOWN
Colorectal Cancer
National Cheng-Kung University Hospital
 2019-01-08 PHASE2
NCT03524508 COMPLETED
Metastatic Biliary Tract Cancer
Changhoon Yoo
 2018-09-04 PHASE2
NCT04151355 UNKNOWN
Colorectal Cancer
Ain Shams University
 2019-10-01
NCT04034355 TERMINATED
Colorectal Cancer; Chemotherapy-induced Peripheral Neuropathy
Egetis Therapeutics
 2019-01-07 PHASE3
NCT02551159 COMPLETED
Squamous Cell Carcinoma of the Head and Neck
AstraZeneca
 2015-10-15 PHASE3
NCT03189719 COMPLETED
Esophageal Neoplasms
Merck Sharp & Dohme LLC
 2017-07-25 PHASE3
NCT02834559 COMPLETED
Rhegmatogenous Retinal Detachment; High-risk for Proliferative Vitreoretinopathy (PVR)
Universitätsklinikum Köln
 2016-10-27 PHASE3
NCT03099486 TERMINATED
Colorectal Cancer
Fox Chase Cancer Center
 2017-10-06 PHASE2
NCT03219580 UNKNOWN
Brow Ptosis; Facial Scarring
Eyelid and Facial Consultants
 2017-05-20 PHASE3
NCT03464968 COMPLETED
Biliary Cancer Metastatic
Seoul National University Bundang Hospital
 2015-07-29 PHASE2
NCT02114359 COMPLETED
Gastric Cancer
Seoul National University Hospital
 2014-02 PHASE3
NCT02099175 UNKNOWN
Sinonasal Tumors
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
 2013-11 PHASE2
NCT02904564 UNKNOWN
Photosensitivity Disorders
Clinica Dermatologica Arbache ltda
 2016-08-20 PHASE4
NCT03812783 UNKNOWN
Hepatocellular Carcinoma
Sun Yat-sen University
 2018-11-05 PHASE2
NCT01465451 UNKNOWN
Colorectal Cancer
Sun Yat-sen University
 2011-03 PHASE3
NCT03002064 UNKNOWN
Esophagus Cancer; Chemotherapy Effects
Sun Yat-sen University
 2016-12 PHASE3
NCT03606928 COMPLETED
Gastric Cancer
Ruijin Hospital
 2018-07-01 PHASE1; PHASE2
NCT03300609 TERMINATED
Colorectal Adenocarcinoma; RAS Wild Type; Stage III Colorectal Cancer AJCC v7; Stage IIIA Colorectal Cancer AJCC v7; Stage IIIB Colorectal Cancer AJCC v7; Stage IIIC Colorectal Cancer AJCC v7; Stage IV Colorectal Cancer AJCC v7; Stage IVA Colorectal Cancer AJCC v7; Stage IVB Colorectal Cancer AJCC v7
University of Southern California
 2018-02-27 PHASE3
NCT02935764 UNKNOWN
Colorectal Carcinoma
Fudan University
 2016-10 PHASE3
NCT01743365 COMPLETED
Gastric Cancer; Gastroesophageal Junction Cancer
Hellenic Cooperative Oncology Group
 2013-02-11 PHASE2
NCT01913639 COMPLETED
Esophageal Cancer; Gastric Cancer
Memorial Sloan Kettering Cancer Center
 2013-07 PHASE2
NCT01858649 COMPLETED
Metastatic Colorectal Cancer
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
 2013-05 PHASE2
NCT03469557 COMPLETED
Esophageal Squamous Cell Carcinoma, Gastric Carcinoma, Gastroesophageal Junction Carcinoma
BeiGene
 2017-07-18 PHASE2
NCT02494583 COMPLETED
Gastric Adenocarcinoma
Merck Sharp & Dohme LLC
 2015-07-31 PHASE3
NCT02928224 COMPLETED
BRAF V600E-mutant Metastatic Colorectal Cancer
Pfizer
 2016-10-13 PHASE3
NCT03294252 TERMINATED
Digestive Cancer
Institut Cancerologie de l'Ouest
 2017-05-24 PHASE1; PHASE2
NCT03197584 WITHDRAWN
Ovarian Cancer
ImmunityBio, Inc.
 2017-12 PHASE1; PHASE2
NCT03085914 COMPLETED
Solid Tumor
Incyte Corporation
 2017-05-02 PHASE1; PHASE2
NCT03169764 WITHDRAWN
Head and Neck Squamous Cell Carcinoma
ImmunityBio, Inc.
 2017-12 PHASE1; PHASE2
NCT03169777 WITHDRAWN
Colorectal Cancer
ImmunityBio, Inc.
 2018-08 PHASE1; PHASE2
NCT03167177 WITHDRAWN
Melanoma
ImmunityBio, Inc.
 2017-12 PHASE1; PHASE2
NCT03244774 UNKNOWN
Gastric Adenocarcinoma
Fujian Cancer Hospital
 2018-01-01 PHASE1
NCT00907543 COMPLETED
Esophageal Neoplasms
Richard Malthaner
 2009-04
NCT02688023 UNKNOWN
Colorectal Cancer
Chinese Academy of Medical Sciences
 2014-03 PHASE2
NCT02319304 TERMINATED
Rectal Adenocarcinoma
University of Maryland, Baltimore
 2015-03 PHASE2
NCT02967887 UNKNOWN
Hepatocellular Carcinoma Non-Resectable
CbsBioscience
 2016-11 PHASE2
NCT01992705 COMPLETED
Resectable Pancreatic Cancer
University of Maryland, Baltimore
 2014-03 EARLY_PHASE1
NCT02453490 TERMINATED
Colorectal Cancer; Liver Metastasis
Zhejiang University
 2015-10-11 PHASE3
NCT01591135 COMPLETED
Esophageal Squamous Cell Carcinoma
Fudan University
 2012-04 PHASE3
NCT03574649 WITHDRAWN
Non Small Cell Lung Cancer
ImmunityBio, Inc.
 2018-06 PHASE2
NCT01185171 COMPLETED
Head and Neck Cancer
University of Chicago
 2003-01-27 PHASE2
NCT02855788 UNKNOWN
Metastatic Gastric Cancer; Locally Advanced Gastric Cancer
Huashan Hospital
 2015-05 PHASE2
NCT02485548 UNKNOWN
Head and Neck Squamous Cell Cancer
Jiangsu Cancer Institute & Hospital
 2015-06 PHASE3
NCT02270606 COMPLETED
Mucinous Adenocarcinoma of the Rectum; Recurrent Rectal Cancer; Signet Ring Adenocarcinoma of the Rectum; Rectal Adenocarcinoma; Stage IIA Rectal Cancer; Stage IIB Rectal Cancer; Stage IIC Rectal Cancer; Stage IIIA Rectal Cancer; Stage IIIB Rectal Cancer; Stage IIIC Rectal Cancer
Virginia Commonwealth University
 2014-12-04 PHASE1
NCT02845908 COMPLETED
Malignant Neoplasm of Stomach Stage IV
Fujian Cancer Hospital
 2015-11 PHASE2
NCT03210064 UNKNOWN
Metastatic Colorectal Cancer
Hui ting Xu，MD
 2017-05-04 PHASE2
NCT00609284 COMPLETED
HNSCC
Groupe Oncologie Radiotherapie Tete et Cou
 2008-02-15 PHASE3
NCT01526135 COMPLETED
Pancreatic Adenocarcinoma (Ductal Adenocarcinoma)
UNICANCER
 2012-04-16 PHASE3
NCT01652976 COMPLETED
Pancreatic Cancer Metastatic
University of Florida
 2012-07 PHASE2
NCT00995293 COMPLETED
Head and Neck Neoplasms
Sanofi
 2009-08-27 PHASE3
NCT01650428 COMPLETED
Rectal Cancer
University College, London
 2013-04 PHASE2
NCT01503372 COMPLETED
Advanced Gastric Cancer
Charite University, Berlin, Germany
 2011-11 PHASE2
NCT03307941 WITHDRAWN
Adenocarcinoma of the Esophagus; Adenocarcinoma of the Gastroesophageal Junction; Squamous Cell Carcinoma of the Esophagus
Jules Bordet Institute
 2017-07-20 PHASE1; PHASE2
NCT02352337 COMPLETED
Metastatic Pancreatic Cancer
Federation Francophone de Cancerologie Digestive
 2015-01-12 PHASE2
NCT02767375 UNKNOWN
Hepatocellular Carcinoma
Peking University Cancer Hospital & Institute
 2015-02 PHASE2; PHASE3
NCT01998347 WITHDRAWN
Esophageal Cancer
Shantou University Medical College
 2013-11 PHASE3
NCT01308086 UNKNOWN
CRC
Hellenic Oncology Research Group
 2010-10 PHASE3
NCT02550678 COMPLETED
Basal Cell Nevus Syndrome; Skin Neoplasm; Nodular Basal Cell Carcinoma of Skin
Ascend Biopharmaceuticals Ltd
 2015-09 PHASE1; PHASE2
NCT01952951 UNKNOWN
Rectal Neoplasms; Adenocarcinoma
National Cancer Center, Korea
 2014-06 PHASE2
NCT02051868 UNKNOWN
Squamous Cell Carcinoma of the Anus
Royal Marsden NHS Foundation Trust
 2013-12 PHASE2
NCT02218164 COMPLETED
Squamous Cell Carcinoma of Skin; Carcinoma, Squamous Cell
H. Lee Moffitt Cancer Center and Research Institute
 2014-08-12 PHASE2
NCT02985255 UNKNOWN
Tongue Neoplasms; Squamous Cell Carcinoma; Anterior Tongue Squamous Cell Carcinoma
HealthCare Global Enterprise Ltd.
 2016-04 PHASE2
NCT01653470 COMPLETED
Cancer
Bristol-Myers Squibb
 2012-10-12 PHASE1
NCT02486497 COMPLETED
Pancreatic Cancer
Seoul National University Hospital
 2015-06
NCT00828386 TERMINATED
Nasopharyngeal Cancers
Groupe Oncologie Radiotherapie Tete et Cou
 2009-01 PHASE3
NCT02981498 COMPLETED
Hepatocellular Carcinoma
Sun Yat-sen University
 2015-06 PHASE2
NCT02987699 UNKNOWN
HepatoCellular Carcinoma
Sun Yat-sen University
 2016-11 PHASE2
NCT02337946 COMPLETED
Colorectal Carcinoma
Takeda
 2014-10-16 PHASE2
NCT00501410 COMPLETED
Colorectal Cancer
M.D. Anderson Cancer Center
 2007-04-23 PHASE1
NCT01836653 COMPLETED
Liver Only Metastasis From KRAS Exon 2 Wild Type (Under Protocol 1.0-1.2 Edition) and RAS Wild Type (Under Protocol 2.0 Edition) Colorectal Cancer
EPS Corporation
 2013-05 PHASE2
NCT01834014 COMPLETED
Liver Metastasis; Colorectal Cancer
EPS Corporation
 2013-05
NCT01211938 COMPLETED
Squamous Cell Carcinoma
Gustave Roussy, Cancer Campus, Grand Paris
 2010-06-15 PHASE2; PHASE3
NCT01964534 UNKNOWN
Metastatic Pancreatic Cancer
GERCOR - Multidisciplinary Oncology Cooperative Group
 2013-12-12 PHASE2
NCT02640365 COMPLETED
Unresectable Advanced Cancer
GERCOR - Multidisciplinary Oncology Cooperative Group
 2015-11-18 PHASE1
NCT02013453 WITHDRAWN
Cancer of Head and Neck
University of Michigan Rogel Cancer Center
 2013-12 PHASE2
NCT03428529 COMPLETED
Rectal Neoplasm Malignant
Instituto Nacional de Cancer, Brazil
 2011-01-12 PHASE2; PHASE3
NCT01364376 COMPLETED
Stomach Neoplasms
Zhejiang University
 2011-06
NCT01836432 TERMINATED
Pancreatic Cancer; Pancreatic Carcinoma Non-resectable; Locally Advanced Malignant Neoplasm
NewLink Genetics Corporation
 2013-05 PHASE3
NCT02062853 COMPLETED
Actinic Keratoses
University of California, Davis
 2012-11
NCT00943137 UNKNOWN
Cancer (Advanced Stage)
National University Hospital, Singapore
 2009-06 PHASE2
NCT04031703 COMPLETED
Breast Cancer
Fudan University
 2011-01-01 PHASE3
NCT00798070 ACTIVE_NOT_RECRUITING
Breast Cancer
Karolinska University Hospital
 2007-02 PHASE3
NCT01765582 TERMINATED
Colorectal Neoplasms
Hoffmann-La Roche
 2013-01-23 PHASE2
NCT02046538 WITHDRAWN
Adenocarcinoma of the Colon; Adenocarcinoma of the Rectum
Weill Medical College of Cornell University
 2014-02 PHASE2
NCT00278694 COMPLETED
Rectal Cancer
Oslo University Hospital
 2005-09 PHASE2
NCT01248299 TERMINATED
Squamous Cell Carcinoma of Esophagus
Centre Oscar Lambret
 2011-01 PHASE2
NCT00525785 COMPLETED
Stomach Cancer; Gastric Cancer
M.D. Anderson Cancer Center
 2004-01 PHASE2
NCT01641458 COMPLETED
Colorectal Cancer
Cantonal Hospital of St. Gallen
 2012-10 PHASE4
NCT01953406 WITHDRAWN
Hepatocellular Carcinoma; Lung Metastasis
Seoul National University Hospital
 2015-11 PHASE2
NCT02426450 UNKNOWN
Hepatocellular Carcinoma
Sun Yat-sen University
 2015-04 PHASE2
NCT01411072 UNKNOWN
Pancreas Cancer
AHS Cancer Control Alberta
 2011-09
NCT02289768 COMPLETED
Actinic Keratosis
Almirall, S.A.
 2014-10 PHASE3
NCT01616849 COMPLETED
Stage IV Nasopharyngeal Carcinoma
Sun Yat-sen University
 2012-05 PHASE2
NCT01126216 TERMINATED
Head and Neck Cancer
University of Erlangen-Nürnberg Medical School
 2010-06 PHASE3
NCT00526110 COMPLETED
Gastrointestinal Diseases
M.D. Anderson Cancer Center
 2004-08 PHASE1; PHASE2
NCT01670721 COMPLETED
Colorectal Cancer Metastatic
Sanofi
 2012-08 PHASE3
NCT01695772 COMPLETED
Colorectal Cancer
Hoffmann-La Roche
 2012-10-16 PHASE4
NCT01181401 COMPLETED
Squamous Cell Carcinoma of the Head; Squamous Cell Carcinoma of the Neck
Charite University, Berlin, Germany
 2010-08 PHASE2
NCT02133014 UNKNOWN
Pancreatitis, Acute Necrotizing
Zhujiang Hospital
 2014-04
NCT01985841 TERMINATED
Breast Cancer
Hellenic Oncology Research Group
 2011-10 PHASE2
NCT02638051 COMPLETED
Peritoneal Neoplasms; Ascites; Yang Deficiency; Yin Deficiency
Galenic Research Institute Ltd
 2014-01 PHASE2
NCT00424827 COMPLETED
Pancreatic Cancer
University of Massachusetts, Worcester
 2006-06 PHASE2
NCT01631539 WITHDRAWN
Liver Metastases; Colorectal Cancer
Universitaire Ziekenhuizen KU Leuven
 2012-09
NCT01661114 COMPLETED
Pancreatic Cancer; Biliary Cancer
University of Michigan Rogel Cancer Center
 2011-07 PHASE2
NCT01220128 TERMINATED
Neoplasms, Breast
GlaxoSmithKline
 2011-04-11 PHASE2
NCT01652482 COMPLETED
Colorectal Cancer
Genentech, Inc.
 2012-10 PHASE2
NCT01661270 COMPLETED
Colorectal Cancer Metastatic
Sanofi
 2012-07 PHASE3
NCT01269216 COMPLETED
Rectal Cancer
Yonsei University
 2008-10 PHASE2
NCT01754623 TERMINATED
Pancreatic Cancer
H. Lee Moffitt Cancer Center and Research Institute
 2013-02 PHASE2
NCT01472029 COMPLETED
Adenocarcinoma of the Gastroesophageal Junction; Adenocarcinoma of the Stomach
AIO-Studien-gGmbH
 2011-12 PHASE2
NCT01285557 TERMINATED
Metastatic Diffuse Gastric Cancer Including Carcinoma of the Gastro-esophageal Junction
Taiho Oncology, Inc.
 2011-04-14 PHASE3
NCT00957905 COMPLETED
Recurrent Extragonadal Seminoma; Recurrent Malignant Extragonadal Germ Cell Tumor; Recurrent Malignant Extragonadal Non-Seminomatous Germ Cell Tumor; Recurrent Malignant Testicular Germ Cell Tumor; Recurrent Ovarian Germ Cell Tumor; Stage III Testicular Cancer; Stage IV Extragonadal Non-Seminomatous Germ Cell Tumor; Stage IV Extragonadal Seminoma; Stage IV Ovarian Germ Cell Tumor
National Cancer Institute (NCI)
 2009-06 PHASE2
NCT00721513 COMPLETED
Head and Neck Cancer
Wake Forest University Health Sciences
 2008-09 PHASE2
NCT01183780 COMPLETED
Colorectal Cancer
Eli Lilly and Company
 2010-12-02 PHASE3
NCT01679327 UNKNOWN
Colorectal Cancer
Chinese Academy of Medical Sciences
 2012-03 PHASE2
NCT01467115 COMPLETED
Head and Neck Cancer
Drexel University College of Medicine
 2010-03 PHASE2
NCT00941499 COMPLETED
Advanced Cancers
M.D. Anderson Cancer Center
 2009-07 PHASE1
NCT00002842 COMPLETED
Colorectal Cancer; Metastatic Cancer
City of Hope Medical Center
 1994-09 PHASE2
NCT01498783 COMPLETED
Central Nervous System Malignancies; Ependymoma
St. Jude Children's Research Hospital
 2011-12 PHASE1
NCT00087178 COMPLETED
Breast Cancer
NSABP Foundation Inc
 2004-05 PHASE3
NCT01399684 COMPLETED
Metastatic Colorectal Cancer
Genentech, Inc.
 2011-11 PHASE2
NCT01536223 UNKNOWN
Chemoradiation; Nasopharyngeal Carcinoma
Zhejiang Cancer Hospital
 2012-04 PHASE3
NCT02048540 COMPLETED
Locally Advanced Gastric Carcinoma
Chinese PLA General Hospital
 2009-02 PHASE1; PHASE2
NCT01053390 COMPLETED
Gallbladder Neoplasms
Shanghai Jiao Tong University School of Medicine
 2009-10 PHASE3
NCT01238939 COMPLETED
Advanced Solid Tumors; Metastatic Colorectal Cancer
Nippon Kayaku Co., Ltd.
 2010-08 PHASE1
NCT01849380 UNKNOWN
Breast Neoplasms; Neoadjuvant Therapy
Shandong University
 2013-06 PHASE4
NCT00756470 TERMINATED
Breast Cancer
M.D. Anderson Cancer Center
 2008-10 PHASE2
NCT01063192 UNKNOWN
Locally Advanced Pancreatic Cancer
National Health Research Institutes, Taiwan
 2009-11 PHASE2
NCT01972503 UNKNOWN
Colorectal Neoplasms; Neoplasm Metastasis; Liver Neoplasms
Xu jianmin
 2008-06 PHASE4
NCT00321685 COMPLETED
Rectal Adenocarcinoma; Stage II Rectal Cancer AJCC v7; Stage III Rectal Cancer AJCC v7
National Cancer Institute (NCI)
 2006-07-25 PHASE2
NCT00524186 TERMINATED
Esophageal Cancer; Gastric Cancer
Roswell Park Cancer Institute
 2007-05 PHASE1
NCT01081041 COMPLETED
Head and Neck Cancer
Eli Lilly and Company
 2010-06 PHASE2
NCT00803647 COMPLETED
Metastatic Colorectal Cancer
NSABP Foundation Inc
 2010-01 PHASE2
NCT00847912 COMPLETED
Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Skin Neoplasms; Skin Diseases; Neoplasms, Basal Cell; Neoplasms, Squamous Cell; Carcinoma
VA Office of Research and Development
 2009-06-26 PHASE4
NCT00941135 TERMINATED
Laryngeal Neoplasms
Fundacion Miguel Servet
 2009-05 PHASE2
NCT00610948 COMPLETED
Unspecified Adult Solid Tumor, Protocol Specific
UNC Lineberger Comprehensive Cancer Center
 2008-03 PHASE1
NCT00646607 COMPLETED
Colon Cancer
Gruppo Italiano per lo studio dei Carcinomi dell'Apparato Digerente
 2007-06 PHASE3
NCT00967616 COMPLETED
Colorectal Cancer; Neoplasms, Colorectal
Daiichi Sankyo
 2009-09 PHASE2
NCT01418222 COMPLETED
Colorectal Cancer
Genentech, Inc.
 2011-09-14 PHASE2
NCT01640782 COMPLETED
Adenocarcinoma of the Stomach; Adenocarcinoma of the Gastroesophageal Junction
Mario Negri Institute for Pharmacological Research
 2005-02 PHASE3
NCT00591045 UNKNOWN
Stomach Neoplasms; Gastric Cancer
Peking University
 2008-01 PHASE2
NCT01073683 UNKNOWN
Larynx Cancer
Rabin Medical Center
 2010-04 PHASE2
NCT00611858 TERMINATED
Rectal Cancer
Dana-Farber Cancer Institute
 2008-05 PHASE2
NCT00079274 COMPLETED
Adenocarcinoma of the Colon; Stage III Colon Cancer
National Cancer Institute (NCI)
 2004-02 PHASE3
NCT00964080 UNKNOWN
Gastric Adenocarcinoma; Gastroesophageal Junction Adenocarcinoma; Esophageal Adenocarcinoma
Mebiopharm Co., Ltd
 2009-05 PHASE1; PHASE2
NCT00632268 COMPLETED
Metastatic Gastric Cancer
National Taiwan University Hospital
 2008-02 PHASE2
NCT01286766 COMPLETED
Gastric Cancer
Yonsei University
 2009-09 PHASE2
NCT00948688 TERMINATED
Pancreatic Cancer; Adenocarcinoma of the Pancreas
Massachusetts General Hospital
 2009-08 PHASE1; PHASE2
NCT00988897 WITHDRAWN
Colorectal Neoplasms
Sanofi
 2009-10 PHASE2
NCT01151761 TERMINATED
Cholangiocarcinoma; Hepatobiliary Neoplasm; Liver Cancer; Bile Duct Cancer; Cancer of Gallbladder
Stanford University
 2011-01 PHASE2
NCT00193882 COMPLETED
Esophagus Cancer
Trans Tasman Radiation Oncology Group
 2003-07-07 PHASE3
NCT01289821 COMPLETED
Colorectal Neoplasms
Bayer
 2011-02 PHASE2
NCT01467921 UNKNOWN
Curatively-resected, Node-positive Esophageal Squamous Cell Carcinoma
Samsung Medical Center
 2010-12 PHASE2
NCT00838370 COMPLETED
Neoplasms
The Netherlands Cancer Institute
 2007-05 PHASE1
NCT00551759 TERMINATED
Esophageal Cancer
Eastern Cooperative Oncology Group
 2008-10-02 PHASE2
NCT00861094 COMPLETED
Esophageal Cancer
UNICANCER
 2008-03 PHASE2; PHASE3
NCT00138177 COMPLETED
Recurrent Colon Cancer; Recurrent Rectal Cancer; Stage III Colon Cancer; Stage III Rectal Cancer; Stage IV Colon Cancer; Stage IV Rectal Cancer; Unspecified Adult Solid Tumor, Protocol Specific
National Cancer Institute (NCI)
 2005-07 PHASE1
NCT01481545 COMPLETED
Rectal Cancer
National Cancer Institute, Naples
 2006-12 PHASE2
NCT01047007 TERMINATED
Solid Tumors
Merck Sharp & Dohme LLC
 2010-01-18 PHASE1
NCT00954512 TERMINATED
Neoplasms
Merck Sharp & Dohme LLC
 2009-09-25 PHASE1; PHASE2
NCT01160419 UNKNOWN
Gastric Cancer
Ludwig-Maximilians - University of Munich
 2009-12 PHASE2
NCT00747799 COMPLETED
Nasopharyngeal Neoplasms
Sun Yat-sen University
 2009-01 PHASE2
NCT00169247 COMPLETED
Larynx Cancer; Hypopharynx Cancer
Groupe Oncologie Radiotherapie Tete et Cou
 2005-10 PHASE2
NCT01360827 TERMINATED
Squamous Cell Carcinoma of the Head and Neck
Merck KGaA, Darmstadt, Germany
 2010-08 PHASE1
NCT00862784 COMPLETED
Colorectal Carcinoma
Eli Lilly and Company
 2009-04 PHASE2
NCT00354978 COMPLETED
Colorectal Cancer
M.D. Anderson Cancer Center
 2005-01 PHASE2
NCT00544362 COMPLETED
Esophageal Cancer
Federation Francophone de Cancerologie Digestive
 2007-07 PHASE1; PHASE2
NCT01177956 COMPLETED
Squamous Cell Carcinoma of the Head and Neck
Merck KGaA, Darmstadt, Germany
 2009-12 PHASE3
NCT00121992 COMPLETED
Breast Neoplasms
Spanish Breast Cancer Research Group
 1999-07 PHASE3
NCT01034683 UNKNOWN
Esophageal Carcinoma
Taian Cancer Hospital
 2009-12 PHASE3
NCT00689624 COMPLETED
Metastatic Colorectal Cancer
University Hospital of Crete
 2007-07 PHASE2
NCT00763646 UNKNOWN
Gastric Junction Adenocarcinoma; Gastroesophageal Junction Adenocarcinoma
McGill University
 2007-04 PHASE2
NCT00642577 COMPLETED
Colorectal Cancer
Hoffmann-La Roche
 2007-07 PHASE3
NCT00513383 COMPLETED
Squamous Cell Carcinoma of the Head and Neck
Massachusetts General Hospital
 2006-04 PHASE1
NCT00736944 COMPLETED
Squamous Cell Carcinoma of the Head and Neck
Washington University School of Medicine
 2008-12-19 PHASE2
NCT02563054 COMPLETED
Gastric Cancer
Hoffmann-La Roche
 2003-04 PHASE3
NCT00915850 UNKNOWN
Esophageal Cancer
Wakayama Medical University
 2007-08 PHASE1; PHASE2
NCT00716417 COMPLETED
Neoplasms
Boehringer Ingelheim
 2008-07-01 PHASE1
NCT00806663 COMPLETED
Metastatic Colorectal Cancer; Liver Metastases
Central European Society for Anticancer Drug Research
 2008-08 PHASE2
NCT00463840 TERMINATED
Pancreatic Cancer
NYU Langone Health
 2004-06 PHASE1; PHASE2
NCT00261703 COMPLETED
Head and Neck Neoplasms
Sanofi
 2002-12 PHASE2; PHASE3
NCT00284258 COMPLETED
Colorectal Cancer
Taiho Pharmaceutical Co., Ltd.
 2006-01 PHASE2; PHASE3
NCT00112918 COMPLETED
Colorectal Cancer
Hoffmann-La Roche
 2004-12 PHASE3
NCT00467142 COMPLETED
Colorectal Cancer
Institut Bergonié
 2007-01-23 PHASE2
NCT01123811 COMPLETED
Adenocarcinoma of Stomach or Esophagogastric Junction
Johannes Gutenberg University Mainz
 2006-05 PHASE2
NCT00307736 COMPLETED
Rectal Cancer; Adenocarcinoma of the Rectum
Massachusetts General Hospital
 2006-05 PHASE1; PHASE2
NCT00761241 COMPLETED
Pancreatic Cancer
Benaroya Research Institute
 2008-09 PHASE2
NCT00399035 COMPLETED
Metastatic Colorectal Cancer
AstraZeneca
 2006-11 PHASE3
NCT00457691 COMPLETED
Metastatic Colorectal Cancer
Pfizer
 2007-06 PHASE3
NCT00786643 COMPLETED
Colorectal Cancer
Accelerated Community Oncology Research Network
 2006-02 PHASE2
NCT00003298 COMPLETED
Gastric Cancer
ECOG-ACRIN Cancer Research Group
 1999-06-01 PHASE2
NCT00502463 COMPLETED
Head and Neck Cancer
Austrian South Oncology Group
 2007-10-03
NCT00559455 COMPLETED
Carcinoma, Hepatocellular
Sanofi
 2007-09 PHASE2
NCT00199173 COMPLETED
Colorectal Neoplasm; Secondary Malignant Neoplasm of Liver
Jules Bordet Institute
 PHASE3
NCT00612586 COMPLETED
Colorectal Cancer
Eli Lilly and Company
 2008-02 PHASE2
NCT00545545 COMPLETED
Recurrent Colorectal Carcinoma; Progressive Colorectal Carcinoma
HiberCell, Inc.
 2007-10 PHASE1; PHASE2
NCT00817895 COMPLETED
Hepatocellular Carcinoma
Eastern Hepatobiliary Surgery Hospital
 2008-12
NCT00209690 COMPLETED
Esophageal Cancer
Hokkaido Gastrointestinal Cancer Study Group
 2003-10 PHASE1; PHASE2
NCT00831181 COMPLETED
Colorectal Cancer
Beth Israel Medical Center
 2004-07 PHASE2
NCT00548548 COMPLETED
Adenocarcinoma
Genentech, Inc.
 2007-09 PHASE3
NCT00209716 COMPLETED
Esophageal Cancer
Hokkaido Gastrointestinal Cancer Study Group
 2003-12 PHASE1; PHASE2
NCT00814528 WITHDRAWN
Actinic Keratosis
University of Chicago
 2007-11
NCT00003135 UNKNOWN
Breast Cancer; Cervical Cancer; Endometrial Cancer; Ovarian Cancer
The University of Texas Health Science Center, Houston
 1997-11 PHASE2
NCT00201396 COMPLETED
Nasopharyngeal Carcinoma
National Health Research Institutes, Taiwan
 2003-08 PHASE3
NCT00004547 COMPLETED
Abdominal Neoplasm; Colonic Neoplasm; Mesothelioma; Peritoneal Neoplasm
National Cancer Institute (NCI)
 2000-01 PHASE2
NCT00086996 COMPLETED
Esophageal Cancer
SWOG Cancer Research Network
 2004-09 PHASE2
NCT00631410 COMPLETED
Colorectal Neoplasms
Pfizer
 2008-01 PHASE1
NCT00508404 COMPLETED
Metastatic Colorectal Cancer
Amgen
 2007-05-09 PHASE2
NCT00422864 COMPLETED
Rectal Cancer
Peter MacCallum Cancer Centre, Australia
 2006-10 PHASE2
NCT00508872 TERMINATED
Colorectal Liver Metastases
M.D. Anderson Cancer Center
 2005-11 PHASE2
NCT00960284 COMPLETED
Pancreatic Cancer
IRCCS San Raffaele
 2003-06 PHASE2; PHASE3
NCT00264472 SUSPENDED
Neoplasms
Adherex Technologies, Inc.
 2006-01 PHASE1
NCT00352755 TERMINATED
Peritoneal Neoplasms
Washington University School of Medicine
 2006-05 PHASE2
NCT00096278 COMPLETED
Colon Adenocarcinoma; Stage IIA Colon Cancer AJCC v7; Stage IIB Colon Cancer AJCC v7; Stage IIC Colon Cancer AJCC v7; Stage IIIA Colon Cancer AJCC v7; Stage IIIB Colon Cancer AJCC v7; Stage IIIC Colon Cancer AJCC v7
National Cancer Institute (NCI)
 2004-09-15 PHASE3
NCT01222052 UNKNOWN
Breast Cancer
Martin-Luther-Universität Halle-Wittenberg
 2002-01 PHASE3
NCT03175939 COMPLETED
Nasopharyngeal Cancer
Sun Yat-sen University
 1998-04-01 PHASE2
NCT00711243 COMPLETED
Gastric Cancer; Unspecified Adult Solid Tumor, Protocol Specific
Northwestern University
 2005-04-20 PHASE1; PHASE2
NCT00280176 COMPLETED
Colorectal Cancer
UNC Lineberger Comprehensive Cancer Center
 2003-04 PHASE1
NCT00259402 COMPLETED
Esophageal Neoplasms
Sanofi
 2000-02 PHASE2
NCT00195572 COMPLETED
Gastric Cancer
Wyeth is now a wholly owned subsidiary of Pfizer
 2002-05 PHASE3
NCT00193219 COMPLETED
Colon Cancer
SCRI Development Innovations, LLC
 2005-07 PHASE2
NCT00153998 COMPLETED
Colorectal Cancer; Liver Metastases
Technische Universität Dresden
 2004-11 PHASE2
NCT00235898 COMPLETED
Colon Cancer; Rectal Cancer
Mast Therapeutics, Inc.
 2005-05 PHASE2
NCT00413322 COMPLETED
Tumor
Valerio Therapeutics
 2005-09 PHASE1
NCT00400179 COMPLETED
Gastric Cancer
Taiho Oncology, Inc.
 2005-05 PHASE3
NCT00143403 COMPLETED
Colorectal Neoplasms; Liver Neoplasms
Pfizer
 2001-12 PHASE3
NCT00393822 COMPLETED
Colon Cancer
Amgen
 2005-08 PHASE2; PHASE3
NCT00619541 COMPLETED
Hepatocellular Carcinoma
Italian Trial in Medical Oncology
 2007-01 PHASE2
NCT00056030 COMPLETED
Colorectal Cancer; Metastatic Cancer
Alliance for Clinical Trials in Oncology
 2004-12 PHASE2
NCT00030342 COMPLETED
Colorectal Cancer; Kidney Cancer
St. Luke's Medical Center
 2001-11 PHASE1; PHASE2
NCT02582970 COMPLETED
Colorectal Cancer
Hoffmann-La Roche
 2005-05 PHASE4
NCT00094965 COMPLETED
Gastrointestinal Cancer
Sanofi
 2004-09 PHASE2
NCT00696488 COMPLETED
Actinic Keratosis
Wake Forest University
 2007-04 PHASE4
NCT00059826 COMPLETED
Pancreatic Cancer
Alliance for Clinical Trials in Oncology
 2003-03 PHASE2
NCT00110721 TERMINATED
Colorectal Cancer
Galectin Therapeutics Inc.
 2005-05 PHASE2
NCT00056446 COMPLETED
Colorectal Neoplasms; Colonic Neoplasms; Rectal Neoplasms
Novartis Pharmaceuticals
 2003-01 PHASE3
NCT00098982 COMPLETED
Colorectal Cancer
European Organisation for Research and Treatment of Cancer - EORTC
 2004-09 PHASE1
NCT00183911 COMPLETED
Gastric Adenocarcinoma; Gastric Cancer
University of Southern California
 2003-11 PHASE2
NCT00139230 COMPLETED
Squamous Cell Carcinoma; Carcinoma of Head/Neck
Dana-Farber Cancer Institute
 1997-01 PHASE2
NCT00199797 COMPLETED
Colorectal Cancer
Ludwig Institute for Cancer Research
 2005-04-18 PHASE1
NCT00006094 COMPLETED
Adenocarcinoma of the Rectum; Stage II Rectal Cancer; Stage III Rectal Cancer
National Cancer Institute (NCI)
 2000-07 PHASE1; PHASE2
NCT00106054 TERMINATED
Colorectal Neoplasms; Liver Neoplasms
Pfizer
 2006-01 PHASE2
NCT00263354 COMPLETED
Stomach Neoplasms
Sanofi
 2003-10 PHASE2
NCT00166465 COMPLETED
Locally Advanced Unresectable or Stage IV Colorectal Cancer
Mayo Clinic
 2003-08 PHASE1; PHASE2
NCT00002984 COMPLETED
Esophageal Cancer
UNC Lineberger Comprehensive Cancer Center
 1997-03 PHASE1; PHASE2
NCT00507091 COMPLETED
Metastatic; Colorectal; Adenocarcinoma
Genzyme, a Sanofi Company
 2005-08 PHASE1
NCT00021073 COMPLETED
Unspecified Adult Solid Tumor, Protocol Specific
National Cancer Institute (NCI)
 2001-05 PHASE1
NCT00002716 COMPLETED
Colorectal Cancer; Metastatic Cancer
Alliance for Clinical Trials in Oncology
 1996-01 PHASE3
NCT00273546 COMPLETED
Cancer
Sanofi
 1999-05 PHASE3
NCT00165191 COMPLETED
Adenocarcinoma of Stomach; Adenocarcinoma of GE Junction; Adenocarcinoma of Esophagus
Dana-Farber Cancer Institute
 1998-08 PHASE2
NCT00139243 COMPLETED
Squamous Cell Carcinoma; Carcinoma of Head and/or Neck
Dana-Farber Cancer Institute
 1997-10 PHASE1; PHASE2
NCT00233623 WITHDRAWN
Metastatic Colorectal Cancer
AstraZeneca
 2004-07 PHASE2
NCT00003596 COMPLETED
Anal Cancer
Radiation Therapy Oncology Group
 1998-10 PHASE3
NCT00003216 COMPLETED
Pancreatic Cancer
Radiation Therapy Oncology Group
 1998-07 PHASE3
NCT00004005 COMPLETED
Carcinoma of Unknown Primary; Colorectal Cancer; Unspecified Adult Solid Tumor, Protocol Specific; Unspecified Childhood Solid Tumor, Protocol Specific
St. Jude Children's Research Hospital
 1998-09 PHASE2
NCT00103103 TERMINATED
Gastric Cancer
California Cancer Consortium
 2005-03 PHASE2
NCT00022139 COMPLETED
Esophageal Cancer; Gastric Cancer
Alliance for Clinical Trials in Oncology
 2002-01 PHASE2
NCT00006248 COMPLETED
Head and Neck Cancer
SWOG Cancer Research Network
 2000-11 PHASE2
NCT00080951 COMPLETED
Colorectal Cancer
Alliance for Clinical Trials in Oncology
 2004-03 PHASE2
NCT00336960 COMPLETED
Colorectal Cancer
Vanderbilt-Ingram Cancer Center
 2002-07 PHASE2
NCT00055822 COMPLETED
Colorectal Cancer
The University of Texas Health Science Center at San Antonio
 2002-10 PHASE1; PHASE2
NCT00193141 COMPLETED
Esophagus Cancer
SCRI Development Innovations, LLC
 1999-10 PHASE2
NCT00003594 COMPLETED
Colorectal Cancer
Alliance for Clinical Trials in Oncology
 1998-10 PHASE3
NCT00193011 COMPLETED
Breast Cancer
SCRI Development Innovations, LLC
 2002-03 PHASE3
NCT00190554 TERMINATED
Esophageal Neoplasms; Carcinoma, Squamous Cell
Japan Clinical Oncology Group
 2000-05 PHASE3
NCT00065117 TERMINATED
Colorectal Neoplasms; Metastases, Neoplasm
AstraZeneca
 2003-09 PHASE2
NCT00004142 COMPLETED
Colorectal Cancer; Metastatic Cancer
M.D. Anderson Cancer Center
 1998-08-05 PHASE2
NCT00215514 COMPLETED
Stomach Cancer; Gastric Cancer; Gastro-esophageal Junction Cancer
Dana-Farber Cancer Institute
 2000-09 EARLY_PHASE1
NCT00003799 COMPLETED
Adenocarcinoma of the Rectum; Mucinous Adenocarcinoma of the Rectum; Signet Ring Adenocarcinoma of the Rectum; Stage IIA Rectal Cancer; Stage IIB Rectal Cancer; Stage IIC Rectal Cancer; Stage IIIA Rectal Cancer; Stage IIIB Rectal Cancer; Stage IIIC Rectal Cancer
National Cancer Institute (NCI)
 1999-05 PHASE1
NCT01693718 COMPLETED
Head and Neck
University of Chicago
 2003-03 PHASE2
NCT00782041 TERMINATED
Uterine Neoplasms
Sanofi
 2003-01 PHASE2
NCT00275210 COMPLETED
Colonic Neoplasms
Sanofi
 1998-10 PHASE3
NCT00003254 COMPLETED
Colorectal Cancer
SWOG Cancer Research Network
 1998-04 PHASE2
NCT00004913 COMPLETED
Unspecified Adult Solid Tumor, Protocol Specific
Northwestern University
 2000-01 PHASE1
NCT00015886 COMPLETED
Breast Cancer
Wake Forest University Health Sciences
 1997-01 PHASE2
NCT00006103 COMPLETED
Colorectal Cancer
Alliance for Clinical Trials in Oncology
 2000-07 PHASE3
NCT00003287 COMPLETED
Colorectal Cancer
European Organisation for Research and Treatment of Cancer - EORTC
 1998-03 PHASE3
NCT00003018 COMPLETED
Pancreatic Cancer
SWOG Cancer Research Network
 1997-09 PHASE2
NCT00004102 COMPLETED
Colorectal Cancer
NYU Langone Health
 1999-01 PHASE2
NCT00006037 TERMINATED
Colorectal Cancer
University of Southern California
 1999-11 PHASE2
NCT00003642 TERMINATED
Bladder Cancer
European Organisation for Research and Treatment of Cancer - EORTC
 1998-10 PHASE2
NCT00004885 COMPLETED
Colorectal Cancer
European Organisation for Research and Treatment of Cancer - EORTC
 1999-07 PHASE3
NCT00002955 COMPLETED
Pancreatic Cancer
University of Southern California
 1995-08 PHASE2
NCT00230451 COMPLETED
Esophageal Cancer
University of Michigan Rogel Cancer Center
 1997-11 PHASE2
NCT00002593 COMPLETED
Colorectal Cancer
SWOG Cancer Research Network
 1994-12 PHASE3
NCT00002722 COMPLETED
Gastric Cancer
European Organisation for Research and Treatment of Cancer - EORTC
 1996-01 PHASE2
NCT00425152 COMPLETED
Colorectal Cancer
NSABP Foundation Inc
 1989-07 PHASE3
NCT00427310 COMPLETED
Colorectal Cancer
NSABP Foundation Inc
 1984-03 PHASE3
NCT00078468 COMPLETED
Colorectal Neoplasms
Pfizer
 2003-12 PHASE2
NCT00323011 TERMINATED
Colorectal Cancer
University of Southern California
 2006-05 PHASE2
NCT00220064 COMPLETED
Upper Gastrointestinal Tumours
Royal Marsden NHS Foundation Trust
 2000-07 PHASE2
NCT00042861 COMPLETED
Unspecified Adult Solid Tumor, Protocol Specific
National Cancer Institute (NCI)
 2002-08 PHASE1
NCT00385021 TERMINATED
Colorectal Neoplasms
Southwestern Regional Medical Center
 2006-10 PHASE2
NCT00611507 COMPLETED
Stomach Neoplasms
Sanofi
 2002-11 PHASE2
NCT00004164 UNKNOWN
Head and Neck Cancer
Dana-Farber Cancer Institute
 1999-08 PHASE2
NCT00001569 COMPLETED
Carcinoma; Peritoneal Neoplasm
National Cancer Institute (NCI)
 1997-01 PHASE1
NCT00121511 COMPLETED
Photo-aging; Keratosis
University of Michigan
 2005-07
NCT00370760 UNKNOWN
Proliferative Vitreoretinopathy
Shahid Beheshti University of Medical Sciences
 2006-09 PHASE3
NCT00003172 COMPLETED
Gastric Cancer
Eastern Cooperative Oncology Group
 1997-12 PHASE2
NCT00563927 UNKNOWN
Nasopharyngeal Neoplasms; Carcinoma, Squamous Cell
Hospital Authority, Hong Kong
 1999-03
NCT00000122 COMPLETED
Glaucoma
National Eye Institute (NEI)
 1985-09 PHASE3
NCT00000758 COMPLETED
HIV Infections; Cervix, Dysplasia
National Institute of Allergy and Infectious Diseases (NIAID)
 PHASE3
NCT00051467 COMPLETED
Pancreatic Cancer
GenVec
 PHASE3
NCT00081536 UNKNOWN
Colorectal Neoplasms
Aronex Pharmaceuticals
 PHASE1; PHASE2
NCT00008281 UNKNOWN
Colorectal Cancer
Sanofi
 2000-10 PHASE3
NCT00046995 UNKNOWN
Colorectal Cancer
Groupe Regional d'Etudes du Cancer Colorectal
 2001-05 PHASE3
NCT00290966 COMPLETED
Stomach Neoplasm
Sanofi
 1998-10 PHASE2; PHASE3
NCT00513266 UNKNOWN
Colorectal Cancer; Metastatic Cancer
Centre Hospitalier Universitaire Vaudois
 2007-06 PHASE2
NCT00001579 COMPLETED
Lymphoma; Neoplasms
National Cancer Institute (NCI)
 1997-06 PHASE1
NCT00309530 COMPLETED
Colon Cancer Stage III
Austrian Breast & Colorectal Cancer Study Group
 1990-10 PHASE3
NCT00047762 COMPLETED
Colorectal Cancer
Genentech, Inc.
 2002-10 PHASE1
NCT00201305 COMPLETED
Biliary Tract Disease
National Health Research Institutes, Taiwan
 2002-07 PHASE2
NCT00001338 COMPLETED
Breast Neoplasms; Fever; Hematologic Diseases; Neutropenia; Sepsis
National Cancer Institute (NCI)
 1993-06 PHASE3
NCT00019513 COMPLETED
Colorectal Cancer; Esophageal Cancer; Extrahepatic Bile Duct Cancer; Gallbladder Cancer; Liver Cancer; Lung Cancer; Lymphoma; Pancreatic Cancer; Small Intestine Cancer; Unspecified Adult Solid Tumor, Protocol Specific
National Institutes of Health Clinical Center (CC)
 1998-08 PHASE1
NCT00088270 COMPLETED
Locally Advanced or Metastatic Adenoca of the Biliary Tract
OSI Pharmaceuticals
 2004-08 PHASE2
NCT00025142 COMPLETED
Colorectal Cancer
Stanford University
 2001-07 PHASE2
NCT00155883 TERMINATED
Gastric Cancer
National Taiwan University Hospital
 2004-06 PHASE2
NCT00003001 UNKNOWN
Colorectal Cancer
Stony Brook University
 1997-04 PHASE1; PHASE2
NCT00162708 COMPLETED
Oropharynx Cancer; Oral Cancer; Hypopharynx Cancer; Larynx Cancer
Gustave Roussy, Cancer Campus, Grand Paris
 1996-07 PHASE2; PHASE3
NCT00005877 UNKNOWN
Colorectal Cancer
Astex Pharmaceuticals, Inc.
 1999-09 PHASE2

(data from https://clinicaltrials.gov, updated on 2025-02-18)

Check the 5-Fluorouracil (5-FU) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

5-Fluorouracil acts as a pyrimidine antimetabolite that noncompetitively inhibits thymidylate synthase, thereby disrupting the production of thymidine monophosphate required for DNA replication and RNA synthesis. This blockade inhibits nucleotide synthesis and triggers cell cycle arrest and apoptosis, thereby limiting tumor cell proliferation in clinical trial conditions such as colorectal, gastric, and pancreatic cancers.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.