CAS No. 5451-09-2
Batch:
Purity:97
Chemical Structure
Check the
5-Aminolevulinic acid HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-amino-4-oxopentanoic acid;hydrochloride | |
|---|---|---|
| CAS Number | 5451-09-2 | |
| Molecular Formula |
C5H9NO3.HCl |
|
| Molecular Weight (MW) | 167.59 | |
| SMILES | C(CC(=O)O)C(=O)CN.Cl | |
| InChIKey | ZLHFONARZHCSET-UHFFFAOYSA-N |
5-Aminolevulinic acid HCl (5-ALA HCl) is an intermediate in heme biosynthesis and a prodrug photosensitizing agent. It is metabolized intracellularly via the porphyrin pathway to generate protoporphyrin IX (PpIX). Upon light activation, accumulated PpIX produces cytotoxic reactive oxygen species (ROS) and free radicals, leading to selective destruction of dysplastic and tumor cells through oxidative stress and apoptosis. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
34 mg/mL
(202.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 34 mg/mL |
| Ethanol | 10 mg/mL |
| DMSO |
34 mg/mL
(202.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 34 mg/mL |
| Ethanol | 6 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
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- 5-Aminolevulinic acid HCl Storage
- 5-Aminolevulinic acid HCl Stability
- 5-Aminolevulinic acid HCl Molecular Weight
- 5-Aminolevulinic acid HCl SMILES
- 5-Aminolevulinic acid HCl Chemical Structure (2D and 3D)
- 5-Aminolevulinic acid HCl SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.