CAS No. 75899-68-2

Batch: Purity:99.27
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4-HNE (4-Hydroxynonenal) Chemical Structure
Chemical Structure
Check the 4-HNE (4-Hydroxynonenal) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (E)-4-hydroxynon-2-enal
CAS Number 75899-68-2
Molecular Formula

C9H16O2
Molecular Weight (MW) 156.22
InChIKey JVJFIQYAHPMBBX-FNORWQNLSA-N

Ordering Information

Biological Activity

4-Hydroxynonenal (4-HNE) is a major bioactive lipid peroxidation end-product and a key mediator of oxidative stress. It forms covalent adducts with nucleophilic amino acid residues on proteins, thereby modifying signal transduction pathways including NF-kB, Nrf2, and MAPK signaling cascades. Through these interactions, 4-HNE modulates cellular redox homeostasis, induces apoptosis, and regulates downstream inflammatory responses across diverse preclinical cellular models. [1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.