CAS No. 3658-77-3

Batch: Purity:99.01
Check CoA
4-Hydroxy-2,5-dimethyl-3(2H)furanone Chemical Structure
Chemical Structure
Check the 4-Hydroxy-2,5-dimethyl-3(2H)furanone product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 3658-77-3
Molecular Formula

C6H8O3
Molecular Weight (MW) 128.13
SMILES CC1C(=O)C(=C(O1)C)O

Biological Activity

4-Hydroxy-2,5-dimethyl-3(2H)furanone (Furaneol, HDMF) is a naturally occurring organic compound with demonstrated antimicrobial and antioxidant activities. It acts by disrupting microbial cellular processes, suppressing bacterial growth and biofilm formation. Additionally, HDMF exhibits radical-scavenging properties that attenuate intracellular oxidative stress, modulating downstream metabolic pathways to protect cells from oxidative damage across various experimental models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 26 mg/mL (202.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] SLAUGHTERJC. Biol. Rev. 1999;74(3):259-276.

Jump to

Note: Technical data last updated: Sep 1, 2026.