CAS No. 90-33-5
Batch:
Purity:99.89
Chemical Structure
Check the
4-Methylumbelliferone (4-MU)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 7-hydroxy-4-methylchromen-2-one | |
|---|---|---|
| CAS Number | 90-33-5 | |
| Molecular Formula |
C10H8O3 |
|
| Molecular Weight (MW) | 176.17 | |
| SMILES | CC1=CC(=O)OC2=C1C=CC(=C2)O | |
| InChIKey | HSHNITRMYYLLCV-UHFFFAOYSA-N |
4-Methylumbelliferone (4-MU) is an orally bioavailable hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM. By depleting cellular HA, 4-MU disrupts downstream HA signaling pathways, leading to the inhibition of cell proliferation, motility, and invasion in various prostate cancer models. Furthermore, treatment at the IC50 concentration induces apoptosis, an effect that can be prevented by exogenous HA addition.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
35 mg/mL
(198.67 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 35 mg/mL |
| Water | Insoluble |
| DMSO |
35 mg/mL
(198.67 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 35 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- 4-Methylumbelliferone (4-MU) Clinical Trials
- 4-Methylumbelliferone (4-MU) Solubility in DMSO
- 4-Methylumbelliferone (4-MU) Stock Solution
- 4-Methylumbelliferone (4-MU) Storage
- 4-Methylumbelliferone (4-MU) Stability
- 4-Methylumbelliferone (4-MU) Molecular Weight
- 4-Methylumbelliferone (4-MU) SMILES
- 4-Methylumbelliferone (4-MU) Chemical Structure (2D and 3D)
- 4-Methylumbelliferone (4-MU) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.