CAS No. 30636-90-9

Batch: Purity:99.96
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(20S)-Protopanaxadiol Chemical Structure
Chemical Structure
Check the (20S)-Protopanaxadiol product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3S,5R,8R,9R,10R,12R,13R,14R,17S)-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol
CAS Number 30636-90-9
Molecular Formula

C30H52O3
Molecular Weight (MW) 460.73
SMILES CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)O)C)C)O)C)O)C
InChIKey PYXFVCFISTUSOO-HKUCOEKDSA-N

Biological Activity

(20S)-Protopanaxadiol is an active ginsenoside metabolite that functions as an inhibitor of P-glycoprotein and cancer cell proliferation. By suppressing ATP-binding cassette transporter function, it attenuates multidrug resistance in resistant cancer cells. Additionally, it modulates apoptotic signaling pathways to induce cell cycle arrest and programmed cell death, thereby decreasing tumor cell viability across various malignant phenotypes. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 92 mg/mL (199.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 33 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Cancer Letters. 2007;252(1):ii.

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Note: Technical data last updated: Sep 1, 2026.