2-DG (2-Deoxy-D-glucose) Mechanism of Action: Hexokinase Inhibition in Virus-Infected Host Cells Research

2-DG (2-Deoxy-D-glucose) MOA:Targeting Hexokinase/Glycolysis Pathway for Viral Infections

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2-Deoxy-D-glucose (2-DG) is a competitive hexokinase inhibitor. It affects PI3K/AKT/mTOR, AMPK, and HIF-1α signaling pathways by blocking glycolysis and depleting cellular ATP, thereby inhibiting tumor cell proliferation and migration, and promoting apoptosis.

Primary Applications and Mechanism of Action