2-Deoxy-D-glucose (2-DG) is a competitive hexokinase inhibitor. By blocking glycolysis and depleting cellular ATP, it activates the AMPK pathway while suppressing PI3K/AKT/mTOR signaling, and modulates HIF-1α activity, thereby inhibiting tumor cell proliferation and migration, and promoting apoptosis.
2-DG (2-Deoxy-D-glucose) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for 2-DG (2-Deoxy-D-glucose) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.