2-Chloroacetamide SDS/MSDS (Safety Data Sheet)

3.1 Substances
Product name: 2-Chloroacetamide
CAS Number: 79-07-2
PubChem CID: 6580
Molecular formula: C2H4ClNO
Molecular weight: 93.51 g/mol
IUPAC name: 2-chloroacetamide

3.2 Mixtures
Not applicable (pure substance).

4.1 Description of first aid measures
Inhalation: Fresh air, rest.
Skin contact: Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eye contact: Rinse with plenty of water for several minutes (remove contact lenses if easily possible).
Ingestion: Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .

4.2 Most important symptoms and effects, both acute and delayed
See Section 11 (Toxicological Information).

4.3 Indication of any immediate medical attention and special treatment needed
Treat symptomatically. Contact a poison control center or physician for severe exposure.

5.1 Extinguishing media
Suitable: Water spray, dry chemical, carbon dioxide (CO2), alcohol-resistant foam.
Unsuitable: None known.

5.2 Specific hazards arising from the substance or mixture
In case of fire in the surroundings, use appropriate extinguishing media.
In case of fire in the surroundings, use appropriate extinguishing media.

5.3 Advice for firefighters
Wear self-contained breathing apparatus (SCBA) and full protective clothing.
Fight fire from upwind. Cool containers with water spray until fire is extinguished.
Flash point: 170 °C

6.1 Personal precautions, protective equipment and emergency procedures
Wear appropriate personal protective equipment (see Section 8).
Avoid breathing dust/vapor. Ensure adequate ventilation.
Evacuate personnel to safe areas. Keep people away from and upwind of spill.
WARNING: Highly toxic — only trained personnel should handle spills.

6.2 Environmental precautions
Prevent product from entering drains, waterways, or soil.
Contain spill with inert absorbent material.

6.3 Methods and materials for containment and cleaning up
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Spillage Disposal. Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.
Do NOT take working clothes home.
Prevent dispersion of dust! Avoid all contact! Use local exhaust or breathing protection.
Do not eat, drink, or smoke during work. Wash hands before eating.

7.1 Precautions for safe handling
Separated from strong oxidants, strong bases, strong acids and food and feedstuffs. Ventilation along the floor. Store in an area without drain or sewer access.
Separated from strong oxidants, strong bases, strong acids and food and feedstuffs. Ventilation along the floor. Store in an area without drain or sewer access.

7.2 Conditions for safe storage, including any incompatibilities
Separated from strong oxidants, strong bases, strong acids and food and feedstuffs. Ventilation along the floor. Store in an area without drain or sewer access.
Separated from strong oxidants, strong bases, strong acids and food and feedstuffs. Ventilation along the floor. Store in an area without drain or sewer access.
Store away from incompatible materials (see Section 10).
[Note: Specific storage temperature not available in public databases. Refer to supplier Certificate of Analysis (COA) for exact storage conditions.]

9.1 Information on basic physical and chemical properties
a) Appearance: Colorless to pale yellow crystals; [HSDB]
b) Odor: Characteristic odor
c) Odor threshold: No data available
d) pH: No data available
e) Melting point/freezing point: 119-120 °C
f) Initial boiling point and boiling range: Approximately 225 °C (decomposes)
g) Flash point: 170 °C
h) Evaporation rate: No data available
i) Flammability (solid, gas): No data available
j) Upper/lower flammability or explosive limits: No data available
k) Vapor pressure: 0.01 [mmHg]
l) Vapor density: No data available
m) Relative density: Relative density of the vapour/air-mixture at 20 °C (air = 1): 1.00
n) Water solubility: In water, 90,000 mg/L at 25 °C
o) Partition coefficient: n-octanol/water: Log P (n-octanol/water): -0.5
p) Auto-ignition temperature: No data available
q) Decomposition temperature: No data available
r) Viscosity: No data available
s) Explosive properties: No data available
t) Oxidizing properties: No data available

9.2 Other information
Topological Polar Surface Area (TPSA): 43.1 Ų
Complexity: 44

11.1 Information on toxicological effects
Acute toxicity:
No acute toxicity data available.
Skin corrosion/irritation:
Causes skin irritation (H315).
Serious eye damage/eye irritation:
Causes serious eye irritation (H319).
Respiratory or skin sensitization:
May cause an allergic skin reaction (H317).
Germ cell mutagenicity:
No data available.
Carcinogenicity:
No data available.
Reproductive toxicity:
Suspected of damaging fertility or the unborn child (H361).
Specific target organ toxicity (single exposure):
No data available.
Specific target organ toxicity (repeated exposure):
No data available.
Aspiration hazard:
No data available.

11.2 Additional information
Exposure routes:
The substance can be absorbed into the body in hazardous amounts by ingestion. The substance can be absorbed into the body through the skin.
Signs and symptoms of exposure:
Cough.
Redness. Pain.
Redness. Pain.
Sore throat.
Data source: Hazardous Substances Data Bank (HSDB) via PubChem.

12.1 Toxicity
EC50; Species: Eisenia andrei (Earthworm) adult; topical >25 mg/kg dry soil for 28 days; Effect: decreased growth
LC50; Species: Eisenia andrei (Earthworm) adult; topical 23.3 mg/kg dry soil for 28 days
EC50; Species: Eisenia andrei (Earthworm) adult; topical 18.5 mg/kg dry soil for 56 days; Effect: decreased progeny counts
LC50; Species: Eisenia fetida (Earthworm) topical using filter paper 2.7 ug/sq cm for 48 hr
LC50; Species: Eisenia fetida (Earthworm) topical 38.5 mg/kg artificial soil for 14 days
The substance is harmful to aquatic organisms.
Chloroacetamide's production and use as an intermediate in the production of herbicides and insecticides may result in its release to the environment through various waste streams. and its former use as a preservative in various cosmetics. If released to air, an estimated vapor pressure of 1.1X10-2 mm Hg at 25 °C indicates chloroacetamide will exist solely as a vapor in the atmosphere. Vapor-phase chloroacetamide will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 5 days. Chloroacetamide does not contain chromophores that absorb at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight. If released to soil, chloroacetamide is expected to have very high mobility based upon an estimated Koc of 4.2. Volatilization from moist soil surfaces is not expected to be an important fate process ba

12.2 Persistence and degradability
No data available.

12.3 Bioaccumulative potential
Log P (n-octanol/water): -0.5
Low potential for bioaccumulation (Log P < 3).

12.4 Mobility in soil
No data available.

12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available.

12.6 Other adverse effects
No other adverse ecological effects identified.

13.1 Waste treatment methods
Waste Treatment Methods: Waste material must be disposed of in accordance with national and local regulations. Leave chemicals in original containers and do not mix with other waste. Handle uncleaned containers in the same manner as the product itself.

14.1 UN number
Not regulated as dangerous goods (research quantities typically exempt).

14.2 UN proper shipping name
Not subject to transport regulations (small quantities for research use).

14.3 Transport hazard class(es)
Class 6.1

14.4 Packing group
Packing group III

14.5 Environmental hazards
Marine pollutant: No (not classified as environmentally hazardous per GHS).

14.6 Special precautions for user
Transport in original packaging. Ensure containers are tightly sealed.
For bulk or commercial quantities, consult applicable transport regulations (DOT, IATA, IMDG).

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable.

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
US EPA / TSCA: Subject to EPA TSCA regulations
EU ECHA / REACH: Registered (REACH Active)

SARA 302 Components:
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components:
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards:
Acute (short-term) health hazard
Chronic (long-term) health hazard

Massachusetts Right To Know Components:
This material contains components subject to the Massachusetts Right to Know Act. See Section 2 for hazard classification.
Pennsylvania Right To Know Components:
This material contains components subject to the Pennsylvania Right to Know Act. See Section 2 for hazard classification.
New Jersey Right To Know Components:
This material contains components subject to the New Jersey Right to Know Act. See Section 2 for hazard classification.

California Prop. 65 Components:
This product does not contain any chemicals known to the State of California to cause cancer, birth defects, or any other reproductive harm.

Other regulatory listings:
- The Australian Inventory of Industrial Chemicals: Chemical: Acetamide, 2-chloro-
- FDA Requirements: Chloracetamide is an indirect food additive for use only as a component of adhesives.

15.2 Chemical safety assessment
A chemical safety assessment has not been carried out for this substance.
For research-use-only compounds, no CSA is required under REACH Annex I.

Revision Date: 2026/09/08
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.