CAS No. 1005-24-9

Batch: Purity:99.94
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1-Methylnicotinamide chloride Chemical Structure
Chemical Structure
Check the 1-Methylnicotinamide chloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-methylpyridin-1-ium-3-carboxamide chloride
CAS Number 1005-24-9
Molecular Formula

C7H9ClN2O
Molecular Weight (MW) 172.61
SMILES [Cl-].C[N+]1=CC=CC(=C1)C(N)=O
InChIKey BWVDQVQUNNBTLK-UHFFFAOYSA-N

Ordering Information

Biological Activity

1-Methylnicotinamide chloride is an active endogenous metabolite of nicotinamide that exhibits prominent anti-inflammatory and anti-thrombotic activities. It selectively stimulates endothelial prostacyclin (PGI2) synthesis through activation of the cyclooxygenase-2 (COX-2) signaling pathway. Through these downstream mechanisms, 1-methylnicotinamide chloride enhances tumor vasculature formation, improves vascular endothelial function, and effectively suppresses thrombosis and platelet aggregation in preclinical disease models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 35 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.