1,4-Dichlorobenzene SDS/MSDS (Safety Data Sheet)

3.1 Substances
Product name: 1,4-Dichlorobenzene
CAS Number: 106-46-7
PubChem CID: 4685
Molecular formula: C6H4Cl2
Molecular weight: 147.00 g/mol
IUPAC name: 1,4-dichlorobenzene

3.2 Mixtures
Not applicable (pure substance).

4.1 Description of first aid measures
Inhalation: Fresh air, rest. Refer for medical attention.
Skin contact: Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eye contact: First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion: Give one or two glasses of water to drink. Refer for medical attention .

4.2 Most important symptoms and effects, both acute and delayed
See Section 11 (Toxicological Information).

4.3 Indication of any immediate medical attention and special treatment needed
Treat symptomatically. Contact a poison control center or physician for severe exposure.

5.1 Extinguishing media
Suitable: Water spray, dry chemical, carbon dioxide (CO2), alcohol-resistant foam.
Unsuitable: None known.

5.2 Specific hazards arising from the substance or mixture
Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:
CAUTION: Fire involving Safety devices (UN3268) and Fire suppressant dispersing devices (UN3559) may have a delayed activation and a risk of hazardous projectiles. Extinguish the fire at a safe distance.
SMALL FIRE: Dry chemical, CO2, water spray or regular foam.
LARGE FIRE: Water spray, fog or regular foam. Do not scatter spilled material with high-pressure water streams. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal.
FIRE INVOLVING TANKS: Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024)
Use water spray, powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.
Approach fire from upwind to avoid hazardous vapors and toxic decomposition products. Use water spray, dry chemical, foam, or carbon dioxide. Use water spray to keep fire-exposed containers cool. Extinguish fire using agent suitable for surrounding fire. /o-Dichlorobenzene/
Water may be used to blanket fire.
If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire (Material itself does not burn or burns with difficulty.).

5.3 Advice for firefighters
Wear self-contained breathing apparatus (SCBA) and full protective clothing.
Fight fire from upwind. Cool containers with water spray until fire is extinguished.
Flash point: 150 °F (NTP, 1992)

6.1 Personal precautions, protective equipment and emergency procedures
Wear appropriate personal protective equipment (see Section 8).
Avoid breathing dust/vapor. Ensure adequate ventilation.
Evacuate personnel to safe areas. Keep people away from and upwind of spill.

6.2 Environmental precautions
Prevent product from entering drains, waterways, or soil.
Contain spill with inert absorbent material.

6.3 Methods and materials for containment and cleaning up
Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
ENVIRONMENTAL HAZARDS: Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans or other waters unless in accordance with the requirements of a National Pollutant Discharge Elimination System (NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA.
Environmental considerations: Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./
Environmental considerations: Water spill: Use natural deep water pockets, excavated lagoons, or sand bag barriers to trap material at bottom. If dissolved, in region of 10 ppm or greater concentration, apply activated carbon at ten times the spilled amount. Remove trapped material with suction hoses. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.
For more Cleanup Methods (Complete) data for 1,4-Dichlorobenzene (6 total), please visit the HSDB record page.
Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U072 and D027, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.
Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber; Contaminated packaging: Dispose of as unused product.
SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.
p-Dichlorobenzene may be disposed of: 1) by making packages of p-dichlorobenzene in paper or other flammable material and burning in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device. 2) By dissolving p-dichlorobenzene in a flammable solvent (such as alcohol) and atomizing in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device. Recommendable method: Incineration.
For more Disposal Methods (Complete) data for 1,4-Dichlorobenzene (13 total), please visit the HSDB record page.
ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
Precautions for safe handling: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.
Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
For more Preventive Measures (Complete) data for 1,4-Dichlorobenzene (18 total), please visit the HSDB record page.

7.1 Precautions for safe handling
Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:
Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent dust cloud. For Asbestos, avoid inhalation of dust. Cover spill with plastic sheet or tarp to minimize spreading. Do not clean up or dispose of, except under supervision of a specialist.
SMALL DRY SPILL: With clean shovel, place material into clean, dry container and cover loosely; move containers from spill area.
SMALL SPILL: Pick up with sand or other non-combustible absorbent material and place into containers for later disposal.
LARGE SPILL: Dike far ahead of liquid spill for later disposal. Cover powder spill with plastic sheet or tarp to minimize spreading. Prevent entry into waterways, sewers, basements or confined areas. (ERG, 2024)
Separated from strong oxidants and food and feedstuffs. Provision to contain effluent from fire extinguishing. Keep in a well-ventilated room. Store in an area without drain or sewer access.
Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): 13: Non Combustible Solids.
Store in cool, dry, well-ventilated location. Separate from oxidizing materials. /o-Dichlorobenzene/
Store in a cool, dry, well-ventilated area between 32 °F and 80 °F. Storage below 80 °F will cause crystals to turn white; storage above 80 °F will cause crystals to fuse and cake. Short-term exposure to extremely high temperatures, above 80 °F, can rapidly cause caking. Inspection of containers should be made within ten days of receipt to determine whether fusing or caking has occurred in transit. Store only in closed, properly labeled containers. /99.9% Paradichlorobenzene/
Safe Storage of Pesticides. Always store pesticides in their original containers, complete with labels that list ingredients, directions for use, and first aid steps in case of accidental poisoning. Never store pesticides in cabinets with or near food, animal feed, or medical supplies. Do not store pesticides in places where flooding is possible or in places where they might spill or leak into wells, drains, ground water, or surface water.

7.2 Conditions for safe storage, including any incompatibilities
Separated from strong oxidants and food and feedstuffs. Provision to contain effluent from fire extinguishing. Keep in a well-ventilated room. Store in an area without drain or sewer access.
Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): 13: Non Combustible Solids.
Store in cool, dry, well-ventilated location. Separate from oxidizing materials. /o-Dichlorobenzene/
Store in a cool, dry, well-ventilated area between 32 °F and 80 °F. Storage below 80 °F will cause crystals to turn white; storage above 80 °F will cause crystals to fuse and cake. Short-term exposure to extremely high temperatures, above 80 °F, can rapidly cause caking. Inspection of containers should be made within ten days of receipt to determine whether fusing or caking has occurred in transit. Store only in closed, properly labeled containers. /99.9% Paradichlorobenzene/
Safe Storage of Pesticides. Always store pesticides in their original containers, complete with labels that list ingredients, directions for use, and first aid steps in case of accidental poisoning. Never store pesticides in cabinets with or near food, animal feed, or medical supplies. Do not store pesticides in places where flooding is possible or in places where they might spill or leak into wells, drains, ground water, or surface water.
Store away from incompatible materials (see Section 10).
[Note: Specific storage temperature not available in public databases. Refer to supplier Certificate of Analysis (COA) for exact storage conditions.]
Store in original container. Keep upright to prevent leakage.

9.1 Information on basic physical and chemical properties
a) Appearance: P-dichlorobenzene appears as a white colored liquid with the odor of moth balls. Denser than water and insoluble in water. Flash point below 200 °F. Used as a moth repellent, to make other chemicals, as a fumigant, and for many other uses.
b) Odor: Distinctive aromatic odor ... becomes very strong at concentrations between 30 and 60 ppm
c) Odor threshold: No data available
d) pH: No data available
e) Melting point/freezing point: 127 °F (NTP, 1992)
f) Initial boiling point and boiling range: 345 °F at 760 mmHg (NTP, 1992)
g) Flash point: 150 °F (NTP, 1992)
h) Evaporation rate: No data available
i) Flammability (solid, gas): No data available
j) Upper/lower flammability or explosive limits: No data available
k) Vapor pressure: 0.6 mmHg at 68 °F ; 1.8 mmHg at 86 °F (NTP, 1992)
l) Vapor density: No data available
m) Relative density: 1.458 at 68 °F (USCG, 1999) - Denser than water; will sink
n) Water solubility: less than 1 mg/mL at 73 °F (NTP, 1992)
o) Partition coefficient: n-octanol/water: Log P (n-octanol/water): 3.4
p) Auto-ignition temperature: No autoflammability up to 500 °C.
q) Decomposition temperature: No data available
r) Viscosity: 0.839 mPa.s at 55 °C; 0.668 mPa.s at 79 °C
s) Explosive properties: No data available
t) Oxidizing properties: No data available

9.2 Other information
Complexity: 54

11.1 Information on toxicological effects
Acute toxicity:
Inhalation Acute Reference Concentration (RfCa) (mg/m^3): 12.024539877300599
Inhalation Acute Reference Concentration Reference: ATSDR Final
Skin corrosion/irritation:
No data available.
Serious eye damage/eye irritation:
Causes serious eye irritation (H319).
Respiratory or skin sensitization:
May cause an allergic skin reaction (H317).
Germ cell mutagenicity:
Suspected of causing genetic defects (H341).
Carcinogenicity:
Suspected of causing cancer (H351).
Reproductive toxicity:
May damage fertility or the unborn child (H360).
Specific target organ toxicity (single exposure):
H370, H372, H373
Specific target organ toxicity (repeated exposure):
No data available.
Aspiration hazard:
No data available.

11.2 Additional information
Carcinogen classification:
para-Dichlorobenzene
Group 2B: Possibly carcinogenic to humans
Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)
Volume 73: (1999) Some Chemicals that Cause Tumours of the Kidney or Urinary Bladder in Rodents and Some Other Substances
1999
1998
1,4-Dichlorobenzene (p-Dichlorobenzene)
TR-319: Toxicology and Carcinogenesis Studies of 1,4-Dichlorobenzene (CASRN 106-46-7) in F344/N Rats and B6C3F1
Exposure routes:
The substance can be absorbed into the body by inhalation and by ingestion.
inhalation, skin absorption, ingestion, skin and/or eye contact
Inhalation (L397) ; oral (L397) ; dermal (L397) ; eye contact (L397)
Signs and symptoms of exposure:
Cough. Sore throat. Drowsiness. Headache. Nausea. Shortness of breath. Vomiting.
Redness. Pain.
Diarrhoea. Further see Inhalation.
Eye irritation, swelling periorbital (situated around the eye); profuse rhinitis; headache, anorexia, nausea, vomiting; weight loss, jaundice, cirrhosis; In Animals: liver, kidney injury; [potential occupational carcinogen]
Burning sensation, cough, drowsiness, headache, nausea, shortness of breath, and vomiting can follow inhalation or ingestion of 1,4-DCB. Moreover
Data source: Hazardous Substances Data Bank (HSDB) via PubChem.

12.1 Toxicity
LC50; Species: Lepomis macrochirus (bluegill sunfish); Conditions: /static bioassay/; Concentration: 4.54 mg/L for 24 hr; 4.3 mg/L for 48 hr; 4.25 mg/L for 96 hr
LC50; Species: Poecilia reticulata (Guppy) age 3 months, weight 0.18 g, length 2.6 cm; Conditions: freshwater, renewal, dissolved oxygen 2.3-8.7 mg/L; Concentration: 19.7 umol/L for 96 hr (confidence interval: 14.8-26.4 umol/L) /95% purity/
LC50; Species: Poecilia reticulata (guppy); Concentration: 4.0 ppm for 14 days /Conditions of bioassay not specified/
LC50; Species: Palaemonetes pugio (grass shrimp); Concentration: 129 mg/L for 48 hr; 69 mg/L for 96 hr /Conditions of bioassay not specified/
For more Ecotoxicity Values (Complete) data for 1,4-Dichlorobenzene (46 total), please visit the HSDB record page.
/AQUATIC SPECIES/ ... Acute and chronic toxicity to freshwater aquatic life occur at concentrations as low as 1,120 and 763 ug/L ... acute toxicity to saltwater aquatic life occurs at concentrations as low as 1,970 ug/L.
/AQUATIC SPECIES/ Developmental, genetic, and reproductive toxicities of benzene, chlorobenzene, and o-, m-, and p-dichlorobenzenes were investigated in sea urchin, Paracentrotus lividus. Toxicity order depended on whether the target organ was embryo or sperm. Benzene was active in sea urchin sperm causing developmental and mitotic abnormalities in offspring. Benzene also showed a significant increase in developmental defects following embryo exposure. For chlorobenzene, developmental defects wer

12.2 Persistence and degradability
No data available.

12.3 Bioaccumulative potential
Log P (n-octanol/water): 3.4
Potential for bioaccumulation exists (Log P > 3).

12.4 Mobility in soil
No data available.

12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available.

12.6 Other adverse effects
This substance is classified as hazardous to the aquatic environment.

13.1 Waste treatment methods
Waste Treatment Methods: Waste material must be disposed of in accordance with national and local regulations. Leave chemicals in original containers and do not mix with other waste. Handle uncleaned containers in the same manner as the product itself.

14.1 UN number
Not regulated as dangerous goods (research quantities typically exempt).

14.2 UN proper shipping name
Not subject to transport regulations (small quantities for research use).

14.3 Transport hazard class(es)
Class 9
DOT label: Class 9

14.4 Packing group
Packing group III

14.5 Environmental hazards
Marine pollutant: Yes (classified as environmentally hazardous per GHS).

14.6 Special precautions for user
Transport in original packaging. Ensure containers are tightly sealed.
For bulk or commercial quantities, consult applicable transport regulations (DOT, IATA, IMDG).

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable.

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
US EPA / TSCA: Subject to EPA TSCA regulations
EU ECHA / REACH: Registered under REACH

SARA 302 Components:
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components:
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards:
Acute (short-term) health hazard
Chronic (long-term) health hazard
Environmental hazard

Massachusetts Right To Know Components:
This material contains components subject to the Massachusetts Right to Know Act. See Section 2 for hazard classification.
Pennsylvania Right To Know Components:
This material contains components subject to the Pennsylvania Right to Know Act. See Section 2 for hazard classification.
New Jersey Right To Know Components:
This material contains components subject to the New Jersey Right to Know Act. See Section 2 for hazard classification.

California Prop. 65 Components:
This product contains a chemical known to the State of California to cause cancer, birth defects, or other reproductive harm.

Other regulatory listings:
- The Australian Inventory of Industrial Chemicals: Chemical: Benzene, 1,4-dichloro- Specific Information Requirement: Obligations to provide information apply. These obligations are: 1. If the assessment report about the chemical recommends secondary
- California Safe Cosmetics Program (CSCP) Reportable Ingredient: Hazard Traits - Carcinogenicity; Dermatotoxicity; Hepatotoxicity and Digestive System Toxicity; Nephrotoxicity and Other Toxicity to the Urinary System; Neurotoxicity; Ocular Toxicity; Reproductive To
- Status Regulation (EC): 2004/129/EC
- New Jersey Worker and Community Right to Know Act: The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
- Atmospheric Standards: This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to us

15.2 Chemical safety assessment
A chemical safety assessment has not been carried out for this substance.
For research-use-only compounds, no CSA is required under REACH Annex I.

Revision Date: 2026/09/09
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.