CAS No. 2216-51-5

Batch: Purity:99.46
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(-)-Menthol Chemical Structure
Chemical Structure
Check the (-)-Menthol product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 2216-51-5
Molecular Formula

C10H20O
Molecular Weight (MW) 156.27
SMILES CC1CCC(C(C1)O)C(C)C

Ordering Information

Biological Activity

(-)-Menthol is a levo isomer of menthol that acts as a potent agonist of transient receptor potential melastatin 8 (TRPM8). Activation of TRPM8 channels by (-)-Menthol induces extracellular calcium ion influx in primary sensory neurons, leading to cellular depolarization and activation of thermosensory pathways. This physiological response mediates cold sensation and modulates nociceptive signal transmission across peripheral nervous system networks. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 31 mg/mL (198.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 31 mg/mL
Water 16 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.