CAS No. 283609-79-0(free base)

Batch: Purity:99.94
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LSKL, Inhibitor of Thrombospondin (TSP-1) acetate Chemical Structure
Chemical Structure
Check the LSKL, Inhibitor of Thrombospondin (TSP-1) acetate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S)-6-amino-N-[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]hexanamide
CAS Number 283609-79-0(free base)
Molecular Formula

C23H46N6O7
Molecular Weight (MW) 518.6
InChIKey YOKXDNNIFSAXBY-QAETUUGQSA-N

Ordering Information

Biological Activity

LSKL is a peptide inhibitor of thrombospondin-1 (TSP-1) that acts as a competitive antagonist to block TSP-1-mediated activation of latent transforming growth factor-beta1 (TGF-beta1). By suppressing downstream TGF-beta1 signaling and Smad pathway activation, LSKL attenuates aberrant fibrotic pathways and tissue remodeling, effectively protecting against the development of subarachnoid fibrosis and hydrocephalus after subarachnoid hemorrhage. [1]

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (192.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 100 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.