CAS No. 183658-72-2

Batch: Purity:98.21
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CYN154806 Chemical Structure
Chemical Structure
Check the CYN154806 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (4R,7S,10S,13R,16S,19S)-19-[[(2S)-2-acetamido-3-(4-nitrophenyl)propanoyl]amino]-10-(4-aminobutyl)-N-[(2R)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
CAS Number 183658-72-2
Molecular Formula

C56H68N12O14S2
Molecular Weight (MW) 1197.34
SMILES CC(O)C1NC(=O)C(CCCCN)NC(=O)C(CC2=C[NH]C3=CC=CC=C23)NC(=O)C(CC4=CC=C(O)C=C4)NC(=O)C(CSSCC(NC1=O)C(=O)NC(CC5=CC=C(O)C=C5)C(N)=O)NC(=O)C(CC6=CC=C(C=C6)[N;v5](=O)=O)NC(C)=O
InChIKey RDTVTSXTFYXNSG-HDNDNHAUSA-N

Ordering Information

Biological Activity

CYN154806 is a cyclic octapeptide acting as a potent and selective somatostatin SST2 receptor antagonist (pIC50 8.58), showing lower affinity for SST1 (pIC50 5.41), SST3 (pIC50 6.07), SST4 (pIC50 5.76), and SST5 (pIC50 6.48) receptors. By selectively blocking SST2 receptor activation, CYN154806 inhibits somatostatin-mediated signaling pathways and downstream cellular responses, serving as a selective pharmacological tool for investigating sst2 receptor functions.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (83.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water 50 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.