CAS No. 579492-81-2
Batch:
Purity:99.88
Chemical Structure
Check the
Bax inhibitor peptide V5
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylsulfanylbutanoyl]amino]-4-methylpentanoyl]amino]hexanoic acid | |
|---|---|---|
| CAS Number | 579492-81-2 | |
| Molecular Formula |
C27H50N6O6S |
|
| Molecular Weight (MW) | 586.79 | |
| InChIKey | NHMUTADCTDDWPV-YFNVTMOMSA-N |
Biological Activity
Bax inhibitor peptide V5 is a cell-permeable pentapeptide derived from Ku70 that functions as an inhibitor of Bax-mediated apoptosis. By mimicking the Bax-binding region of Ku70, it prevents Bax conformational activation, membrane translocation, and mitochondrial outer membrane permeabilization. Consequently, Bax inhibitor peptide V5 blocks cytochrome c release and suppresses downstream caspase activation, promoting cell survival under apoptotic stress conditions. [1]
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(170.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.