HomeNew Topoisomerase Inhibitors

New Topoisomerase Inhibitors

Catalog No. Product Name Information
E8306 ABBV-969 Payload ABBV-969 Payload is an agent-linker conjugate with a potent inhibitor of topoisomerase I and a linker designed for use in the antibody-drug conjugate (ADC) ABBV-969. It can be used in non-small cell lung cancer research.
E8269 Eleutherin Eleutherin ((+)-Eleutherin) is a pyranonaphthoquinones that is isolated from the bulb of Eleutherine americana and a potent catalytic inhibitor of Topoisomerase II. It exhibits potent anti-cancer activity and protects human umbilical vein endothelial cells (HUVECs) from injury in vitro.
S1889 Mitoxantrone Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively.
E8164 Daunorubicin Daunorubicin is an anthracycline antibiotic and a cell cycle–nonspecific chemotherapeutic agent that functions by inhibiting topoisomerase II and intercalating into DNA. It is primarily indicated for the treatment of acute lymphoblastic leukemia (ALL) and acute myelogenous leukemia (AML).
E5775 Exatecan Exatecan (DX-8951), is a water-soluble derivative of camptothecin. It acts as an inhibitor of DNA topoisomerase I with an IC50 value of 1.906 μM. It demonstrates potent antitumor effects and triggers apoptotic cell death after treatment in human pancreatic cancer cells.
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