New PARP Inhibitors

HomeNew PARP Inhibitors

Catalog No. Product Name Information
E4942 Talazoparib tosylate SGC-AAK1-1 is a chemical probe that functions as a potent and selective inhibitor of AAK1 (AP2-associated kinase 1), exhibiting an IC50 of 270 nM and a Ki of 9 nM. It also demonstrates strong inhibitory activity against BMP2K. This compound serves as a research tool for investigating the Wnt pathway associated with AAK1.
E5851 T26 T26( PARP1-IN-35) is a potent, selective, orally active, inhibitor of PARP1 capable of crossing the blood-brain barrier, with IC50 values of 0.2 nM. It exhibits significant antitumor efficacy and holds potential as a research treatment for breast cancer metastases.
E5842 Nudifloramide Nudifloramide (2PY, N-methyl-2-pyridone-5- carboxamide) is a pyridine derivative of nicotinamide that inhibits PARP-1 (poly (ADP-ribose) polymerase-1) activity in vitro, with an IC50 of 8 µM.
F2623 PARP1 Antibody [F9N15] PARP,PARP1
E4719 XYL-1 XYL-1 is a highly potent inhibitor of PARP7 with and IC50 of 0.6 nM. It could enhance the type-Ⅰinterferon signaling in vitro, and can be a potential candidate for developing cancer immunotherapy agents.
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