New JAK Inhibitors

Cat.No. Product Name Information
S2275 Gandotinib (LY2784544) Gandotinib is a potent, selective and ATP-competitive inhibitor of janus kinase 2 (JAK2) tyrosine kinase with IC50 of 3 nM. Gandotinib may have the potential to effectively reduce the JAK2V167F-induced MPN pathogenesis.
S8162 Upadacitinib (ABT-494) Upadacitinib (ABT-494) is a selective JAK1 inhibitor which demonstrates activity against JAK1 (0.045 μM) and JAK2 (0.109 μM), with > 40 fold selectivity over JAK3 (2.1 μM) and 100 fold selectivity over TYK2 (4.7 μM) as compared to JAK1.
S6524 NSC 42834 NSC42834 is an inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK2 with IC50 values between 10 and 30 μM.
S6521 WHI-P258 WHI-P258 is an inhibitor of JAK3 with Ki value of 72 μM.
S8684 Selective JAK3 inhibitor 1 Selective JAK3 inhibitor 1 is an irreversible JAK3 inhibitor with Ki values of 0.07 nM, 320 nM, 740 nM for JAK3, JAK1 and JAK2 respectively. It is also selective over the other kinases possessing a cysteine in the same region as JAK3, such as BMX, EGFR, ITK, and BTK.
All JAK Inhibitors