LPL Receptor Inhibitors

Featured Inhibitors
Inhibitors (2)
Modulators (3)
Agonists (6)
Activator (1)
Antagonists (12)

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
E7015	PF-543	PF-543 (Sphingosine Kinase 1 Inhibitor II) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 is >100-fold selectivity for SPHK1 over SPHK2. PF-543 is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. PF-543 induces apoptosis, necrosis, and autophagy.	Cell Death Dis, 2024, 15(12):926 BioRxiv, 2021, 10.1101/2020.05.12.090571
S7177	PF-543 hydrochloride	PF-543 hydrochloride, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and K_i of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform. This compound induces apoptosis, necrosis, and autophagy.	Cell Death Discov, 2025, 11(1):29 FASEB J, 2025, 39(12):e70768 Sci Rep, 2025, 15(1):9786

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

E7015

PF-543

PF-543 (Sphingosine Kinase 1 Inhibitor II) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 is >100-fold selectivity for SPHK1 over SPHK2. PF-543 is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. PF-543 induces apoptosis, necrosis, and autophagy.

Cell Death Dis, 2024, 15(12):926

BioRxiv, 2021, 10.1101/2020.05.12.090571

S7177

PF-543 hydrochloride

PF-543 hydrochloride, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and K_i of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform. This compound induces apoptosis, necrosis, and autophagy.

Cell Death Discov, 2025, 11(1):29

FASEB J, 2025, 39(12):e70768

Sci Rep, 2025, 15(1):9786

Verified customer review of PF-543 hydrochloride