LPL Receptor Inhibitor

Featured Inhibitors
Inhibitor (1)
Modulators (3)
Agonists (6)
Activator (1)
Antagonists (11)

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S7177	PF-543 hydrochloride	PF-543 hydrochloride, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and K_i of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform. This compound induces apoptosis, necrosis, and autophagy.	Cell Death Discov, 2025, 11(1):29 FASEB J, 2025, 39(12):e70768 Sci Rep, 2025, 15(1):9786

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S7177

PF-543 hydrochloride

PF-543 hydrochloride, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and K_i of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform. This compound induces apoptosis, necrosis, and autophagy.

Cell Death Discov, 2025, 11(1):29

FASEB J, 2025, 39(12):e70768

Sci Rep, 2025, 15(1):9786

Verified customer review of PF-543 hydrochloride