BET Modulators

Featured Inhibitors
Inhibitors (60)
Modulators (2)
Chemicals (6)

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S8889	MZ-1	MZ-1 is a PROTAC degrader of bromodomain-containing protein 4 (BRD4). This compound binds to the Brd bromodomain with Kd of 62 nM, 60 nM, 21 nM, 13 nM, 39 nM and 15 nM for Brd2^BD1, Brd2^BD2, Brd3^BD1, Brd3^BD2, Brd4^BD1 and Brd4^BD2.	Journal of Biological Chemistry, 2025 Aug 12, 110590 Journal of Biological Chemistry, 2025, 110590 J Biol Chem, 2025, 301(9):110590
S6993	(+)-JQ1 carboxylic acid	(+)-JQ1 carboxylic acid ((+)-JQ1-COOH) is a (+)-JQ1 with a carboxylic acid functional group. (+)-JQ1 carboxylic acid ((+)-JQ1-COOH) can be used as a precursor to a PROTAC that targets BET bromodomains after conjugation to a linker and E3 ligase ligand.	J Immunother Cancer, 2023, 11(4)e006070 Journal for ImmunoTherapy of Cancer, 2023, e006070

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S8889

MZ-1

MZ-1 is a PROTAC degrader of bromodomain-containing protein 4 (BRD4). This compound binds to the Brd bromodomain with Kd of 62 nM, 60 nM, 21 nM, 13 nM, 39 nM and 15 nM for Brd2^BD1, Brd2^BD2, Brd3^BD1, Brd3^BD2, Brd4^BD1 and Brd4^BD2.

Journal of Biological Chemistry, 2025 Aug 12, 110590

Journal of Biological Chemistry, 2025, 110590

J Biol Chem, 2025, 301(9):110590

S6993

(+)-JQ1 carboxylic acid

(+)-JQ1 carboxylic acid ((+)-JQ1-COOH) is a (+)-JQ1 with a carboxylic acid functional group. (+)-JQ1 carboxylic acid ((+)-JQ1-COOH) can be used as a precursor to a PROTAC that targets BET bromodomains after conjugation to a linker and E3 ligase ligand.

J Immunother Cancer, 2023, 11(4)e006070

Journal for ImmunoTherapy of Cancer, 2023, e006070