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How to Cite 1. For In-Text Citation (Materials & Methods): 2. For Key Resources Table: |
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Technical Data
| Formula | C21H21F3N4O2 |
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| Molecular Weight | 418.41 | CAS No. | 2603528-97-6 | ||||
| Solubility (25°C)* | In vitro | DMSO | 84 mg/mL (200.76 mM) | ||||
| Ethanol | 21 mg/mL (50.19 mM) | ||||||
| Water | Insoluble | ||||||
| In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | ART558 is a potent, selective, low molecular weight, allosteric inhibitor of DNA Polθ with an IC50 of 7.9 nM. | ||
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Protocol (from reference)
References
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Selleck's ART558 Has Been Cited by 4 Publications
| Disparate Pathways for Extrachromosomal DNA Biogenesis and Genomic DNA Repair [ Cancer Discovery, 2025, 69-82] | PubMed: 37961138 |
| Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells [ Leukemia, 2025, 2152-2162] | PubMed: 37358557 |
| ADH5/ALDH2 dehydrogenases and DNA polymerase theta protect normal and malignant hematopoietic cells from formaldehyde challenge: therapeutic implications [ Leukemia, 2025, 39(9):2152-2162] | PubMed: 40640557 |
| Defects in DNA damage signaling and cell cycle checkpoints in a mouse model of Rhno1 deletion [ Cell Death Discovery, 2025, Article number: 12] | PubMed: nan |
RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.