Spartalizumab

Catalog No.A2017 Synonyms: PDR001 Non-humanized mouse model applicable

For research use only. Not for use in humans.

Spartalizumab is a humanized anti-PD-1 IgG4 antibody that blocks the binding of PD-L1 and PD-L2 to PD-1. It binds to PD-1 with high affinity and inhibits the biological activity of PD-1.

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Choose Selective PD-1/PD-L1 Inhibitors

Biological Activity

Description Spartalizumab is a humanized anti-PD-1 IgG4 antibody that blocks the binding of PD-L1 and PD-L2 to PD-1. It binds to PD-1 with high affinity and inhibits the biological activity of PD-1.
Targets
PD-1 [1]
()
In vivo In phase 1/2 studies, PDR001 has a manageable safety profile and preliminary antitumor activity in advanced solid tumors[1].

Protocol

Product Details

Formulation PBS buffer, pH 7.2
Isotype Human IgG4
Source CHO cells
Storage Store at -80°C and avoid freeze-thaw cycles.

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03081494 Recruiting Metastatic Colorectal Cancer Novartis Pharmaceuticals|Novartis June 9 2017 Phase 1
NCT03172936 Recruiting Solid Tumors and Lymphomas Novartis Pharmaceuticals|Novartis September 8 2017 Phase 1
NCT03066648 Recruiting Leukemia|Leukemia Myeloid|Leukemia Myeloid Acute|Myelodysplastic Syndromes|Preleukemia|Bone Marrow Diseases|Hematologic Diseases Novartis Pharmaceuticals|Novartis July 6 2017 Phase 1
NCT03301896 Recruiting Solid Tumors Novartis Pharmaceuticals|Novartis January 31 2018 Phase 1
NCT03609424 Not yet recruiting Gastrointestinal Stromal Tumors Asan Medical Center|Novartis September 30 2018 Phase 1|Phase 2
NCT02807844 Recruiting Triple Negative Breast Cancer|Pancreatic Carcinoma|Melanoma|Endometrial Carcinoma Novartis Pharmaceuticals|Novartis June 29 2016 Phase 1|Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID