P2X7 Receptor Antibody [L17L11]

Catalog No.: F1511

For research use only.

    Home Primary Antibodies P2X7 Receptor Antibody [L17L11]

    Application: Reactivity:

    Usage Information

    Dilution
    1:1000
    1:50
    Application
    WB, IP
    Reactivity
    Human
    Source
    Rabbit Monoclonal Antibody
    Storage Buffer
    PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3
    Storage (from the date of receipt)
    -20°C (avoid freeze-thaw cycles), 2 years
    Predicted MW
    78 kDa

    Datasheet & SDS

    Biological Description

    Specificity
    P2X7 Receptor Antibody [L17L11] detects endogenous levels of total P2X7 receptor protein.
    Clone
    L17L11
    Synonym(s)
    P2X purinoceptor 7; P2X7; ATP receptor; P2Z receptor; Purinergic receptor; P2RX7
    Background
    The P2X7 receptor (P2X7R) is a unique member of the ATP-gated cation channel P2X family, defined by its requirement for unusually high extracellular ATP concentrations for activation. Structurally, each P2X7R subunit is a 595–amino acid protein encoded by the P2RX7 gene on chromosome 12q24.31, comprising two transmembrane helices, a large glycosylated extracellular loop harboring ATP-binding sites, and intracellular N- and C-terminal domains, with the extended C-terminus containing unique regulatory motifs. Three subunits assemble into a homo-trimeric receptor, though occasional hetero-trimerization with P2X4 and other P2X subunits occurs. P2X7R is broadly expressed in immune cells, glial cells, and various peripheral tissues, with debated neuronal expression. Functionally, it mediates rapid Na⁺ and Ca²⁺ influx and K⁺ efflux upon ATP binding; with prolonged stimulation, it can form large pores permeable to organic cations, triggering inflammatory signaling, cytokine release, and cell death. This receptor plays critical roles in immunity, inflammation, neurodegeneration, cancer progression, and psychiatric disorders, making it a key therapeutic target.
    References
    • https://pubmed.ncbi.nlm.nih.gov/33182829/
    • https://pubmed.ncbi.nlm.nih.gov/32848594/

    Tech Support

    Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

    Handling Instructions

    Tel: +1-832-582-8158 Ext:3
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